Nos publications
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
Drug Development & Delivery, Vol. 17, No. 7, p.20-25 - oct 2017
This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Amélioration de la biodisponibilité des substances actives via la formulation [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies] galénique
STP Pharma Pratiques, Mai-Juin 2017, n°1 - 2017
The SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
Interestingly this article is both in French and English languages.
Table of content:
I Introduction
II Prerequisites
1 Initial identification and characterization of the active ingredient
1.1 Physico-chemical characteristics
1.2 Impact of physicochemical characteristics on absorption
1.3 Passive diffusion prediction tools
1.4 In silico prediction
2 Biopharmaceutical classifications
III Formulation strategies
1 Prerequisites
2 Techniques for increasing the dissolution rate
3 Solubility enhancement technologies
4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
1 Physicochemical control methods for the manufacturing intermediates and finished products
2 Assessing and predicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
VI Conclusion: decision tree
In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates
International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - déc 2016
Maisine® CC, a unique pharmaceutical oil for solubility and oral bioavailability enhancement
Gattefossé - oct 2016
This white paper features Maisine® CC (glyceryl monolinoleate NF), a unique pharmaceutical oil that has a long and successful history of use in lipid-based formulation for drug solubilization and oral bioavailability enhancement.
Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity
International Journal of Pharmaceutics, Volume 495, Issue 1, Pages 385-392 - nov 2015
This article describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcumin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
Reaching milestones in lipid-based formulations: from effective prediction to successful development
sep 2015
This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
Formulation of a self-emulsifying lipid formulation of curcumin
AAPS Annual Meeting & Exposition – San Diego (USA) - 2014
Polyoxylglycerides and glycerides: Effects of manufacturing parameters on API stability, excipient functionality and processing
International Journal of Pharmaceutics, Volume 466, Issues 1–2, Pages 109-121 - mai 2014
Characterization of a new self-emulsifying excipient to expand formulation options for poorly soluble drugs: Gelucire® 48/16
AAPS Annual Meeting & Exposition – Chicago (USA) - oct 2012