Nos publications

In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal tract

  • Poster

AAPS PharmSci360 – San Antonion (USA)  - nov 2019

Dumont C., Jannin V., Beloqui A., Préat V., Fessi H.c, Bourgeois S.

In this study the authors obtained solid lipid nanoparticles using high pressure homogeneization, in which leuprolide was included as an ion pair. The nanoparticles were shown to be internalized by Caco-2 and Caco-2/HT29-MTX cell monolayers. 

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In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery

  • Poster

CRS Annual Meeting – Valencia (Spain)  - jui 2019

Camille Dumont, Ana Beloqui, Sandrine Bourgeois, Véronique Préat, Hatem Fessi, Vincent Jannin

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In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract

  • Scientific publication

International Journal of Pharmaceutics, Volume 565, Pages 409-418 - jui 2019

Camille Dumont, Sandrine Bourgeois, Hatem Fessib, Pierre-Yves Dugas, Vincent Jannin

Lipid-based nanosuspensions for oral delivery of peptides, a critical review

  • Scientific publication

International Journal of Pharmaceutics, Volume 541, Issues 1–2, Pages 117–135 - avr 2018

Camille Dumont, Sandrine Bourgeois, Hatem Fessi, Vincent Jannin

In this review article, the authors describe:


the different techniques used to prepare Solid Lipid Nanoparticles and Nanostructured Lipid Carriers
the methods used to assess the protective effects of the carriers on peptides


the techniques used to measure the permeability enhancement

Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation

  • Scientific publication

European Journal of Pharmaceutical Sciences , Volume 111, Pages 91-95 https://doi.org/10.1016/j.ejps.2017.09.049 - jan 2018

In this study, solid lipid nanoparticles (SLN) of glyceryl dibehenate are produced by two methods and evaluated for digestion using the in vitro lipolysis test.


By ultrasonication, SLN have a mean particle size of 180 nm and showed a limited digestion by lipase.


By spray-flash evaporation, SLN particle size ranges from 235 to 411 nm, depending on process conditions and were not digested by lipase.

In vitro lipolysis study of nanoparticulate delivery systems: solid lipid nanoparticles and nanostructured lipid carriers

  • Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - nov 2013

V. JANNIN, E. DELLERA, S. CHEVRIER, Y. CHAVANT, C. VOUTSINAS, C. BONFERONI, F. DEMARNE

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