Nos publications

Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets

  • Poster

AAPS Annual Meeting & Exposition – Denver (USA)  - nov 2016

C. J. Kapadia, A. R. Shrivastava, G. R. Khanvilkar

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Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API

  • Poster

CRS Annual Meeting – Seattle (2016)  - 2016

Ketkee Deshmukh, Chhanda Kapadia, Agnivesh Shrivastava, Gayatri Khanvilkar, Pradnya Vaingankar and Purnima Amin

The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications. 

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