Nos publications
Process analytical strategies for size monitoring: offline, at-line, online, and inline methods in a top-down nano-manufacturing line
Pharmaceutics - mai 2025
This study highlights that combining offline, at-line, in-line, and online DLS methods enables thorough monitoring across the entire lipid nanoparticles production process. This integrated approach streamlines operations, supports real-time process adjustments, and ensures dependable quality control both post-production and during storage.
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
A QbD-based UPLC-ELSD method for quantifying medium-chain triglycerides in Labrafac™ WL 1349 for nanoemulsion applications
Molecules - jan 2025
This article showcases the development and validation of a robust UPLC-ELSD method, using analytical Quality-by-Design principles, to accurately quantify medium-chain triglycerides in a lipid-based excipient for nanoemulsion applications, ensuring compliance with regulatory standards.
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Bigels: case studies of an innovative topical dosage form
ABCF Congress - nov 2024
Adherence to treatments is a key challenge for topical formulations. Bigels, formulated with Emulfree® Duo are an innovative dosage form that can combine both hydrophilic and lipophilic active ingredients in a stable, moisturizing, and easily spreadable formulation. This study showcases three different placebo bigels formulations.
Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
PBP - mar 2024
This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.
Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
PBP - mar 2024
Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing
PBP - mar 2024
Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
PBP - mar 2024
Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).