Nos publications | Gattefossé

Veterinary soft chews using Gelucire® 50/13 and Precirol® ATO 5. A proof of concept with wet extrusion

Poster

ECP - mar 2025

Fleur Guénard, Cécile Morin, Ceren Yuece, Philippe Caisse

This study aims to demonstrate the effectiveness of Gelucire® 50/13, a surfactant, and Precirol® ATO 5, a taste-masking agent, in producing veterinary soft chews using a wet extrusion process. These ingredients enable the development of high-drug load formulations with taste-masking capabilities and customizable drug release profiles, making them ideal for this innovative dosage form.

Télécharger (.pdf - 318.46 Ko)

Comparing the effect of adding Gelucire® 48/16 and Gelucire® 50/13 in amorphous solid dispersion: a case study with ticagrelor

Poster

CRS - jui 2024

Lolie Chéron, Cédric Miolane, Philippe Caisse

When amorphous solid dispersion (ASD) are produced by hot melt extrusion (HME), the use of a neat polymer requires high process temperatures, and the drug release is not always complete. Adding Gelucire® in the formula is a promising strategy to address these issues.

Télécharger (.pdf - 438.78 Ko)

Advantages of combining polymers and lipids in extrusion processes

Poster

PBP - mar 2024

Ceren Yüce, Lolie Cheron, Anja Geissler-Fichtner, Elsa Gattefossé

Lipid excipients lower the glass transition temperature of polymers, enabling hot-melt extrusion at lower engine torque for better processability. Different polymers and lipid combinations have been tested to explore their potential in extrusion processes.

Télécharger (.pdf - 350.43 Ko)