Nos publications
Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug
AAPS Annual Meeting & Exposition – San Diego (USA) - nov 2017
Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
Journal of Excipients and Food Chemicals, Vol. 8, Issue 1, pages 5-17 - mar 2017
In the present study the lubricant capacity of Compritol® HD5 ATO was compared with commonly used amphiphilic lubricants. The
effect of the concentration and mixing time on flow properties, tablet ejection force, hardness, disintegration time and rate of dissolution of paracetamol tablets was evaluated.
The physical properties of the lubricants such as crystallinity, wettability, thermal behaviour and surface area were also measured.
Compritol® HD5 ATO was found to be an as effective a lubricant for a fast disintegrating paracetamol formulation containing microcrystalline cellulose, lactose and PVP prepared by wet granulation in comparison with sodium stearyl fumarate and PEG 6000.