Names and synonyms
USP NF Name
Caprylocaproyl Polyoxyl-8 glycerides
EP Name
Caprylocaproyl macrogol-8 glycerides
UNII Code (FDA)
00BT03FSO2
Preferred Substance Name (FDA)
PEG-8 CAPRYLIC/CAPRIC GLYCERIDES
Handbook of Pharmaceutical Excipients
Polyoxylglycerides
Chemical description
Consists of a small fraction of mono-, di- and triglycerides and mainly PEG-8 (MW 400) mono- and diesters of caprylic (C8) and capric (C10) acids
Key characteristics
Product form
Liquid
Viscosity (mPa.s)
80 – 110 (20°C)
CMC (mg/L, 25°C)
42 ±24
HLB
12
Main functionalities
Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required). Safety of use is inferred by extensive toxicological evaluations and precedence of use.
Main formulation technologies
Topical gel, microemulsion, and foam. Solutions, suspensions.
