Emulium® Mellifera MB est le premier émulsionnant H/E qui s’adapte au type de peau et au climat, enveloppant la peau dans un film invisible qui la protège contre les conditions extrêmes.
Imaginé et formulé par des équipes à travers le monde, Emulium® Mellifera MB crée des textures légères et douces d’une grande beauté et finesse. Quand la peau se sent bien, les résultats sont visibles. Hydratation, luminosité, texture et douceur, Emulium® Mellifera MB apporte la garantie d’une peau plus jeune et en meilleure santé.
Emulium® Mellifera MB apporte une solution sensorielle aux attentes des consommateurs du monde entier, offrant du plaisir à l’application et une efficacité visible.
Au cœur de cet émulsionnant se cache un savoir-faire unique : l’association de cires naturelles et de polyglycérol végétal pour créer des beurres de cires amphiphiles aux propriétés uniques.
Pour Emulium® Mellifera MB, le choix des chercheurs s’est porté sur les cires d’abeille et de jojoba, présentant toutes deux des caractéristiques complémentaires. Le beurre de cires ainsi obtenu est ensuite associé à du polyglyceryl-6 distearate et à de l’alcool cétylique pour optimiser ses capacités émulsionnantes et texturantes.
Evaluation clinique :
Hydrate la peau et améliore visiblement son aspect
Améliore le confort des peaux sensibles
Protège la peau contre la pollution
Respecte la flore cutanée
Sensorialité :
Emulsions blanches et brillantes
Etalement facilité
Très faible film résiduel (le plus fin de tous les émulsionnants Gattefossé)
Pas de fini gras ni collant
Sensation après application douce et confortable
Adaptation au climat et saisons :
Emulium® Mellifera MB contient des cires végétales fonctionnalisées qui laissent un film doux et imperceptible à la surface de la peau. Ce film joue un rôle clé en aidant la peau à s’adapter à son environnement.
Dans la nature, les cires sont connues pour protéger les plantes de la déshydratation et sans elles de nombreuses espèces ne pourraient pas survivre aux saisons. Emulium® Mellifera MB apporte ce rôle protecteur à la peau.
Evaluation clinique :
Hydrate la peau et améliore visiblement son aspect
Améliore le confort des peaux sensibles
Protège la peau contre la pollution
Respecte la flore cutanée
Sensorialité :
Emulsions blanches et brillantes
Etalement facilité
Très faible film résiduel (le plus fin de tous les émulsionnants Gattefossé)
Pas de fini gras ni collant
Sensation après application douce et confortable
Revendications
Ne contient pas de PEG
S’adapte automatiquement au climat
Hydratant
Protège contre la pollution
Peut être utilisé sur peaux sensibles et hyper-réactives (testé cliniquement)
Applications
Des textures de soins entièrement flexibles
Textures d’inspiration asiatique
Lotions et crèmes solaires avec SPF à la sensation légère
Formulations certifiées biologiques et naturelles
FORMULATIONS
Accès direct aux documents et informations techniques
Softer Skin Stick (2613-1.17) is a 99% natural origin scrub in the practical form of a stick. It is possible to use it on dry skin or on wet skin for a more slippery application. Its texture, stabilized with Emulium® Dolcea MB, emulsify on contact with water, for an easy rinsing.
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\n\n
Everything Balm (2620-1.02) is a 99% natural origin anhydrous multifunctional balm that takes care of the skin of the face, the body, the hands and also the lips and the hair. It contains Acticire® MB which allows the incorporation of aqueous ingredients such as active ingredients or colorants, for more customization!
\n
\n\n
Magma Mask (2618-2.52) is a 98% natural origin mask in the form of surprising solid black pellets, obtained thanks to Geleol™ MB and Emulium® Kappa MB. One pellet represents a unique dose of a product, making it possible to take only the needed quantity. First, crush a pellet of the Magma Mask in your palm, then take a bit of 2620-1.02 Everything Balm (or alternatively hot water). Mix to form a thick black mask to spread directly onto the skin and rinse after 10 minutes.
\n
\n\n
Scalp & Body Scrub (2628-1.07) is a 94% natural origin anhydrous wax with grains of sodium bicarbonate that gently exfoliates and cleanses the scalp, then rinses easily as grains will be dissolved by water, leaving no particles in the hair. The presence of Emulium® Kappa MB helps to improves rinsing while Acticire® MB boosts foam formation. It can also be used on the body for a 2-in-1 application.
\n
\n\n
Slide n’ Foam (2621-2.09) is a 92% natural origin solid face cleanser that invites to a new gesture! Apply the product directly onto dry skin, then rub the skin with wet hands to create foam, boosted by Acticire® MB, and clean the skin. Thus, the product is not damaged by water and is gentler for the skin. Indeed, only the right amount is applied thanks to its melting texture obtained with the help of Lipocire™ A SG.
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Triglycerides medium chain
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Discover how dual matrix containing two sustained release(SR) agents, Compritol® 888 ATO and HPMC enables the production of robust SR tablets. \n
\n\n
With dual matrix, you can:
\n
\n
reduce the SR agent concentration
\n
reduce the alcohol quantity used in wet granulation process
\n
reduce drug release variability
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achieve high drug dose tablet by direct compression
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1,3-Propanediol is an excellent natural alternative to petroleum-based glycols (propylene glycol, butylene glycol, or methyl propanediol) and glycerine. In cosmetics, 1,3-Propanediol is a multipurpose ingredient, acting as an emollient, humectant, booster, solvent, viscosity enhancer, and carrier for actives. 1.3-Propanediol is also miscible with the majority of glycols and alcohols, as well as water, and gives better performance in both skin and hair moisturization when compared to standard glycols. Well suited to sensitive skin, even at high concentration, 1,3-Propanediol meets the many standards of modern cosmetic formulations.
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The agreement, which is effective immediately, will allow Gattefossé to expand its natural product offering for Canadian customers.
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«As a well-known supplier of naturally based ingredients, the philosophy of our company fits well with that of Connect Chemicals. Adding propanediol to our Canadian portfolio allows us to bring a more rounded natural offering to our customers in the region», states Eric Brun, President & CEO of Gattefossé USA & Canada.
\n
\n
Connect Chemicals has a special focus on cosmetic raw materials from renewable and sustainable sources, offering a wide range of COSMOS/ECOCERT certified products.
\n
Glory Biomaterial Industry is a worldwide market leader in bio-based chemicals. Glory developed its proprietary and patented process for the production of 1,3-Propanediol (COSMOS/ECOCERT certified) from renewable sources that are GMO-free. Glory is a proud member of RSPO (Roundtable on Sustainable Palm Oil) as a sign of its strong commitment towards the environment.
\n
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On the picture from left: Dario Monti, Product Manager, Connect Chemicals; A. Başar Karaca, Managing Director, Connect Chemicals; Eric Brun, President, Gattefossé USA & Canada; Carl Philipps, Vice President Operations, Gattefossé Canada
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Discover Dermacare and learn how our pharmaceutical grade emulsifiers can be used to create an exciting range of topical dosage forms with excellent texture and sensorial properties that will delight patients.
An incredible texture for this balm, well-adapted for massage.
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The thickness is brought by a subtle combination of Compritol® 888 Pellets, Geleol™ Mono and Diglecerides NF and hydrogenated castor oil.
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Suppocire® bases comprise chemically stable fatty acid esters with a narrow melting range. Their physicochemical properties provide numerous formulation and manufacturing advantages, including optimized solidification properties and straightforward scale-up with low, medium, and high throughput manufacturing equipment. Careful selection of the right Suppocire® base ensures optimal physicochemical stability and drug delivery properties, as defined by European Pharmacopeia requirements. In addition, Suppocire® formulations are usually simple binary mixtures of the API dissolved or dispersed in the suppository base. They do not require additional excipients to enhance performance, quality, or stability. Step 1: Suppocire® melting Suppocire® pellets are heated at 20 °C above the melting point—indicated in the product technical data sheet—while stirring to ensure the base is thoroughly melted and perfectly homogenized. Step 2: API addition The API is added at a temperature above the recrystallization temperature of the base, generally 30–45 °C. Stirring continues during addition of the API to ensure homogeneity. Step 3: Blister filling The melted, homogenized mixture is poured into the mold at a specific temperature, as determined by a thermorheogram. A thermorheogram plots viscosity versus temperature and allows you to find the optimal mold or blister filling temperature during production. Since viscosity is a function of the specific formulation ingredients, a thermorheogram is necessary for each formulation. Gattefossé has a thermorheogram for each grade of product in the product page section.
\n
Gattefossé can help you identify the appropriate suppository or pessary base optimized for your API and manufacturing equipment. We also provide advice on formulating to obtain physicochemical stability and performance and solve manufacturing or quality issues. For further information, please contact your local representative.
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Hot melt extrusion is a continuous solvent-free technology with precise process control. Lipid excipients are mainly used as matrix formers for modified release, or as solubilizers for solubility/bioavailability enhancement, alone or in combination with polymers.
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Advantages of lipid excipients in hot melt extrusion:
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low melt viscosity, resulting in low torque
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low extrusion temperatures (30–75 °C)
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low melting point and instant solidification, thereby avoiding downstream cooling
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
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Agent texturant 100% naturel basé sur un complexe de cires fonctionnalisées à l’aide de polyglycerol, Acticire® MB forme un film doux et lisse qui protège la peau de la déshydratation et apporte une sensation de confort qui dure toute la journée.
Agent texturant 100% naturel basé sur un complexe de 3 cires fonctionnelles :
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Cire de jojoba
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Cire de tournesol
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Cire Mimosa
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La cire de jojoba est la seule cire liquide à température ambiante. Ceci est dû à la présence d’esters d’alcool gras insaturés combinés avec un acide gras insaturé.
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La cire de tournesol est une cire dure composée de monoesters entièrement saturés qui bénéficie d’une excellente stabilité thermique.
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La cire de mimosa est un coproduit de l’industrie de la parfumerie. Plus douce que les autres cires, elle fond à environ 60° C et a une composition plus complexe : des esters à longue chaîne, des hydrocarbures et une plus petite quantité d’alcools triterpénoïdes.
Acticire® MB is est un ingrédient multifonction aux applications variées. Cette vidéo illustre l’utilisation d’Acticire® MB pour introduire des ingrédients aqueux au sein de formules anhydres.
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Dans cet exemple, un colorant hydrophile est incorporé dans la phase aqueuse. On peut voir comme il est bien dispersé au sein du stick en présence d’Acticire® MB.
Ces trois cires ont été transestérifiées en présence de polyglycérine végétale, les rendant ainsi plus compatibles et stables en émulsion, et leur conférant de nouvelles qualités sensorielles :
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douceur à l’application et étalement facile
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sensation de confort qui dure tout au long de la journée
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Acticire® MB apporte trois bénéfices distincts aux formulations cosmétiques :
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Il forme un film doux et lisse qui protège la peau de la déhydratation
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Il améliore la texture et l’application des formules standard et naturelles
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Il permet d’ajouter de l’eau ou des actifs solubles dans l’eau au sein de systèmes anhydres tout en assurant leur stabilité
En émulsions, peut se substituer à certains émulsifiants à faible HLB
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Peut émulsifier jusqu’à 15% d’eau en phase huileuse, offre une grande stabilité à la chaleur et permet l’introduction d’eau ou d’actifs solubles dans l’eau au sein de formules anhydres
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Réduit la perte d’eau transépidermique, hydrate et améliore l’apparence de la surface de la peau (in vivo tests)
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Améliore la stabilité de la formulation
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Création de formules innovantes
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Améliore les qualités sensorielles
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Offre une hydratation et un confort durables
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\n","applications":"
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Soins : émulsions H/E ou E/H, baumes pour les lèvres, baumes de massage, lignes hydratantes naturelles
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Formations de soins solaires avec des niveaux élevés de filtre UV
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Maquillage : fond de teint de (émulsions ou gels), rouges à lèvres, mascaras
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Emulsions are, by definition, unstable systems and require a surfactant. To enable simple formulation of stable emulsion system, Gattefossé offers a range of self-emulsifying bases consisting of all-in-one excipients. Due to their specific compositions combining lipophilic and hydrophilic surfactants with texture agents, they provide stable emulsions whatever the type and concentration of oil.
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Emulsions are traditionally produced by separately preparing oily and aqueous phases and then mixing them together. Critical process parameters are temperature, blade type, mixing speed and duration, and cooling conditions. Emulsions with Gelot™ 64 are obtained in this way.
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A one-pot process is an interesting alternative whereby all ingredients are mixed in a single step. This is achievable with a powerful emulsifier like Tefose® 63 at a minimum concentration of 12%.
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A cold process might be necessary for heat-sensitive drugs. In such cases, the best emulsifier is Plurol® Diisostearique, which permits formulation at room temperature.
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Emulsification is obtained when mixing and heating yield enough energy to disperse the oil droplets in the aqueous phase, or vice versa. Thus, to obtain a stable emulsion, mixing conditions need to be carefully defined during development and scale-up.
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Our formulators have worked on scale-up—from lab- to pilot-scale production—with different formulations and equipment.
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Ask for our Dermacare brochure \n
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Il a connu au cours de son existence de nombreuses modifications et est aujourd’hui un magazine papier de 28 pages et dont la réputation n’est plus à faire dans l’univers du marché cosmétique. Il s’organise autour de trois axes principaux qui en révèlent les fondements : « s’inspirer », « comprendre » et « créer ». Chaque nouveau numéro apporte avec lui, ses décodages de marchés, ses solutions galéniques, ses analyses plus scientifiques pour provoquer l’envie ou faire naître chez son lecteur les idées les plus novatrices. 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support and applicative formulation | Gattefossé","_yoast_wpseo_metadesc":"Our 4 application laboratories worlwide provide the technical support you need to develop and improve your cosmetic care and drug formulas."},"categories":[48],"tags":[],"acf":{"component":"PageGenericContentCorporate","title":"Applications","content":"
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Gattefossé application laboratories are responsible for demonstrating the benefits our ingredients can offer to prototype formulations. They provide the technical support you need to develop your cosmetic care and drug formulas. Our experts use their detailed understanding of your sector to model and solve your formulation problems.
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Our formulators work in close collaboration with research and development to analyze the behavior of Gattefossé ingredients and excipients and demonstrate their benefits in formulations. We offer our customers efficient and innovative solutions that match global cosmetic and pharmaceutical trends and comply with applicable regulations.
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\n
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Four application laboratories inspiring innovation
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Gattefossé’s four application laboratories are located in France, China, India, and the United States. These strategic positions permit close, local relationships with our customers.
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The laboratories provide personalized service and technical support to help optimize the performance of your cosmetic and pharmaceutical products by using our ingredients. All four sites comply with the safety, hygiene, and quality standards required of our profession and are equipped with the same advanced technologies our customers use, thus guaranteeing manufacturing process reproducibility.
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\n
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Our pharmaceutical application laboratories
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The goals of our pharmaceutical application laboratories are:
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To create and share orientation supports,
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To provide customer assistance and formulation support,
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To offer technical trainings to our network and customers.
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Our formulators advocate the use of a variety of excipients and therefore address a range of dosage forms for different routes of administration:
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Oral administration—production of controlled-release oral dosage forms, enhancement of active ingredient bioavailability through self-emulsifying lipid formulations (SELFs), development of solid SELFs, etc.
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Topical administration—formulation of O/W and W/O emulsions, ointments, and anhydrous gels, and characterization of their sensorial properties
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Anal and vaginal administration—selection of the most appropriate suppository bases for an active ingredient and development and characterization of suppositories and pessaries
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Our cosmetic application laboratories
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Our cosmetic application laboratories apply their technical expertise to fulfill their missions:
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evaluation of our active and functional formulation ingredients
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qualification of new raw materials
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co-creation of innovative products in response to regulatory changes and new market trends, with the help of our R&D teams
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development of formulas specifically requested by our customers
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design of raw material formula kits
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Every day Gattefossé applies its full range of experience with dosage form design to offer customers original formulas—with textures matching current trends—for all applications: face, body, and hair care; makeup; \n ecofriendly products, sunscreens, and more.
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\n
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Sensory analysis, a unique expertise in textures
\n\n
Gattefossé knows skin care and beauty products stimulate all the senses, so we attach great importance to the sensorial evaluation of our products and formulas. We have been developing our expertise in sensorial analysis since 1996.
\n
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As a leader in the field, we have established a panel of experts specialized in the characterization of textures—cosmetic products and topical pharmaceutical formulations in particular. They can accurately assess the physical and sensorial properties of any product and translate these impressions into objective data, regardless of whether they are evaluating our own formulas or other products on the market.
\n
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Our sensory database has been constantly enriched over the course of twenty years and spans over 400 formulations to help us best respond to customer requests.
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\n
Three main steps govern drug diffusion from the formulation to the skin:
\n
\n
Solubility: the formulation must solubilize a sufficient amount of drug to reach the effective concentration at the target site
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Partition: the drug must partition out of the delivery vehicle into the upper layers of the SC
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Diffusion: the drug molecule diffuses through the SC mainly via the intercellular path
\n
\n
Discover Gattefossé range of excipients for solubilization and skin penetration:
Evaluating skin permeation with in vitro release test (IVRT) and in vitro permeation test (IVPT)
\n
In vitro methods exist to assess the drug penetration through the skin: IVRT uses synthetic membranes while IVPT uses animal or human skin.
\n
\n
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Rigorous protocols need to be developed to ensure the reliability of the results. Detailed information is given in our joint webinar with Teledyne Hanson provider of Franz cells. Gattefossé has developed standard protocols to evaluate skin penetration properties of our excipients in formulations. Access our publications for more details or contact us.
\n
\n","box_links":[{"link":"https://www.gattefosse.com/?page_id=22303","title":"On-demand webinar","external_link":"https://register.gotowebinar.com/recording/1077705433127806977","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Transcending-transdermal-delivery-690-375-px.jpg"}],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/pharmaceuticals-special-content/publications-on-skin-drug-delivery/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/27004"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/37"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=27004"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/27004/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=27004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=27004"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=27004"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"publications-on-suppositories-and-pessaries":{"id":4276,"date":"2017-05-08T08:47:48","date_gmt":"2017-05-08T08:47:48","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=4276"},"modified":"2020-12-23T12:03:37","modified_gmt":"2020-12-23T10:03:37","slug":"publications-on-suppositories-and-pessaries","status":"publish","type":"page","link":"https://www.gattefosse.com/canada-events/pharmaceuticals-special-content/publications-on-suppositories-and-pessaries/","title":{"rendered":"Publications on suppositories and pessaries"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on suppositories and pessaries | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on suppositories and pessaries."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on suppositories and pessaries","introduction":"List of Gattefossé publications on suppositories and pessaries.","":false,"content":[{"wysiwyg":"
Rectal route in the 21st century to treat children.
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Jannin, V., Lemagnen, G, Gueroult, P., Larrouture, D., Tuleu, C.
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Advanced Drug Delivery Reviews, 73 34-49. doi: 10.1016/j.addr.2014.05.012
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This article reviews the use of the rectal route for the pediatric population. Main advantages are that these dosage forms are neither to be swallowed nor need to be taste-masked, and can be administered in an emergency to unconscious or vomiting children. The review contains the list of all drugs used in pediatrics rectal forms, some insights on excipients and manufacturing processes, new dosage form developments, patient acceptability, and child physiology.
\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/pages/4276"}],"collection":[{"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/comments?post=4276"}],"version-history":[{"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/pages/4276/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/media?parent=4276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/categories?post=4276"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/canada-events/wp-json/wp/v2/tags?post=4276"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"clean-beauty":{"id":10080,"date":"2018-07-22T20:17:49","date_gmt":"2018-07-22T18:17:49","guid":{"rendered":"https://www.gattefosse.com/?page_id=10080"},"modified":"2019-05-03T11:11:55","modified_gmt":"2019-05-03T09:11:55","slug":"clean-beauty","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-trend/clean-beauty/","title":{"rendered":"The New No-Nos"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":17,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[56],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCos","title":"The New No-Nos","content":"
A look at Clean Beauty
\n
The typical beauty consumer applies 150 different ingredients to his or her face each and every day (Figaro, 2017). In today’s environment of increasing transparency and accountability, consumers want to know the risks they incur when they apply products to their face or body.
\n
Where “green” or “natural” used to be the key buzzwords, today we see more and more products moving to “clean beauty” where naturality is good, but safety is paramount.
\n
\n
\n
Clean Beauty Defined
\n
Still a recent concept in beauty, “clean” is an idea that originally began in the food industry and moved into personal care with the introduction of slow beauty, which goes beyond natural and focuses on conscious consumption. Not to be confused with “natural” or “organic”, the term “clean” refers to products formulated without so-called harmful ingredients such as parabens, phthalates, or even retinol.
\n
Consume smarter, respect the environment, monitor what we use: many people today pay more attention to their well-being, but also to their impact on the planet, than ever before. Consumers are already well tuned to transparency, environmental and safety concerns when talking about food, sport, or wellness, and their increased awareness is rubbing off on their cosmetic consumption. In other words, today’s consumer wants to take back the reigns of their beauty routine and put common sense and understanding into it.
\n
\n
#cleanbeauty \n The hashtags #eatclean or #healthyeating are already widely used on Instagram, but #cleanbeauty isn’t far behind – with 813,000 posts as of July 2018.
\n
\n
\n
A Trend with a Future
\n
A growing segment of consumers are looking for natural beauty products – natural ingredients, claims, and labels continue to grow in prevalence and popularity. But clean goes is a similar but different direction. With a positioning that sits between ethics and safety, the target for this claim is huge, even universal – since all consumers of cosmetics want and expect safe products.
\n
And major retailers like Sephora are jumping on board. Sephora has recently launched “clean at Sephora” which identifies certain products as being “they beauty you want, minus the ingredients you don’t”. Brands that are granted the “clean at Sephora” seal must be free from SLS, SLES, parabens, formaldehydes, phthalates, mineral oil, retinyl palmitate, oxybenzone, and more. They must also contain less than 1% of synthetic fragrances. It’s the no-no list taken to the next level.
\n
\n
Saavy Consumers turn to their Phones
\n
For all but the most knowledgeable consumers, the INCI listing remains largely indecipherable. To assist consumers in their purchasing decisions, many apps have emerged promising to decode the composition of all kinds of products from home cleansers to skin care.
\n
By scanning a product’s bar code, the consumer can have an immediate assessment of the supposed danger or safety of the product and a run-down of the controversial ingredients or allergens it contains.
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\n
\n\n
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Apps like ThinkDirty allow consumers \n to analyze ingredients and make clean \n purchasing decisions.
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\n\n
\n
\n
Just as Shazam lets us recognize the title of any song we hear, in one click these apps let us know if a product is good for our skin and health.
\n
It’s important to note that these apps are controversial due to the sometimes questionable scores they provide, but it’s equally important to realize that many consumers are relying on this information for clarity in what they consider a murky situation.
\n
\n
EWG
\n
The Environmental Working Group (EWG) is a non-profit organization that strives to “protect human health and the environment”. As part of these efforts, the group has created a ranking system for cosmetic products and ingredients, designed to reflect potential health hazards. The ranking system goes from 1-10 with a rating of 1-2 considered as low hazard (green).
\n
The EWG ranking has rapidly gained interest in certain markets, particularly in Asia, where the claim “EWG Green” has become increasingly important. Additionally, many companies in other markets, such as the US, are also turning to EWG as a basis for the creation of clean products and formulations.
\n
\n
\n
Creating Clean Beauty
\n
Gattefossé ingredients are well positioned to meet both the natural and clean beauty movements. Many of our textures and actives are both natural and EWG green, meeting the needs of both markets.
\n
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For a complete list of our natural and EWG Green ingredients, click here.
\n
\n
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MOD MB:
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INCI: Octyldodecyl Myristate
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COSMOS approved
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Provides a rich feel, brings comfort to formulations
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DPPG CG:
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INCI: Propylene Glycol Dipelargonate
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Provides a dry skin feel
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Silicone alternative
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Isostearyl Isostearate:
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INCI: Isostearyl Isostearate
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Provides a rich feel and presence to formulations
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Mineral oil alternative
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Forme un film protecteur
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Maintient la fonction barrière de la peau
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Améliore l’étalement et la sensorialité d’une formule
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All fields of application
\n","actives":"","actives_secondary":"","textures":["emollients"],"textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/pages/1820"}],"collection":[{"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/comments?post=1820"}],"version-history":[{"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/pages/1820/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/media?parent=1820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/categories?post=1820"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/personal-care-formulation-finder/wp-json/wp/v2/tags?post=1820"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"locations":{"id":1209,"date":"2017-03-16T09:29:48","date_gmt":"2017-03-16T09:29:48","guid":{"rendered":"http://217.109.87.212/front/?page_id=1209"},"modified":"2022-02-08T12:03:53","modified_gmt":"2022-02-08T10:03:53","slug":"locations","status":"publish","type":"page","link":"https://www.gattefosse.com/foundation-expertise/corporate-map/locations/","title":{"rendered":"Interactive map"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Locations | where to find your Gattefossé nearest representative","_yoast_wpseo_metadesc":"With more than 60 countries covered, we provide an extensive network of technical and marketing teams at your service. Don't hesitate to contact us!"},"categories":[51],"tags":[],"acf":{"title":"OUR AFFILIATES AND DISTRIBUTORS WORLWIDE","description":"One of the driving forces behind Gattefossé’s development is its global presence. With a responsive and highly trained sales network, we offer our customers strong service with a local approach specific to their markets. To find the Gattefossé representative nearest you, please refer to the map below. \r\n \r\nClick on the pins to display information. Click and hold the left mouse button down to drag the map.","":false,"collaborators":[{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Algeria","name":"Gattefossé Mediterranean","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"Dar El Beïda alger","lat":"36.710817033128436","lng":"3.228515626396984"},"production_site":"Gattefossé Mediterranean","address":"Dar el Baida, \r\nAlger, \r\nAlgeria","description":"","image":false,"zone":"africa_middle_east","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Brazil","name":"Gattefossé do Brasil","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-23.497382874338456","lng":"-46.84701204299927"},"production_site":"Gattefossé do Brasil","address":"Alameda Grajau 129 cj 604 – Alphaville \r\nBarueri, SP 06454050 \r\nBRAZIL \r\n \r\n+55 11 2970-1010 \r\n","description":"
Gattefossé Group created Gattefossé Do Brasil in 2012, a worldwide affiliate located in São Paulo. The objective of this entity is to reinforce Gattefossé’s presence in Latin America, a growing market and a place for opportunities for both personal care and pharmaceutical ingredients. Lead by Mrs Amanda Botelho Pimentel, Gattefossé Do Brasil supports Gattefossé’s distributors in this promising territory, and facilitates contacts with all customers in Latin America. With the help of both its pharmaceutical and personal care distributors, Gattefossé has now the capacity to support its customers more efficiently, by making its technical and marketing expertise locally available to its customers.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Canada","name":"Gattefossé Canada ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"43.68848838417244","lng":"-79.58850145339966"},"production_site":"Gattefossé Canada Inc. ","address":"190 Attwell Drive – Suite 600 \r\nTORONTO , ON, M9W 6H8 \r\nCANADA \r\n \r\n+1 416 243 5019","description":"
Gattefossé Canada Inc. was established in 1997 to service Personal Care, Pharmaceutical and Nutraceutical industries in Canada. Since its creation, this unit has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Under the leadership of Eric Brun, Ph.D., our specialized team (marketing and technical support, customer service) is fully committed to servicing our customers from our locations (offices and warehouses) in Montreal and Toronto.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"China","name":"Gattefossé China ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"31.02234042904364","lng":"121.7669677734375"},"production_site":"Gattefossé China Trading Co. Ltd","address":"Room 5301, Building No. 5, \r\nLane 338, Galileo Road, \r\nPudong District, SHANGHAI \r\nCHINA \r\n \r\n+86 21 5895 8010","description":"
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"France","name":"Gattefossé France","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"48.885159995263706","lng":"2.261037289572414"},"production_site":"Gattefossé France","address":"Gattefossé France \r\nImmeuble Kastle \r\n2 Ter, Rue du Château \r\n92200 Neuilly-Sur-Seine \r\nFrance \r\n \r\n+33 1 41 47 19 00","description":"
Créé en 1993 et adapté aux spécificités du marché français, Gattefossé France a toujours marqué sa volonté de s’engager aux côtés de ses clients en allant au-delà de son rôle de fournisseur de matières premières. Gattefossé France a notamment structuré son offre de manière à allier intimement besoins en formulation et démarche créative, pour accompagner cosmétologues et galénistes dans la globalité de leurs problématiques.
\n
Les ingrédients Gattefossé, issus de savoir-faire en oléochimie et extraction biologique, ciblent les besoins clients aussi bien en cosmétique qu’en pharmacie humaine et vétérinaire. \n Les polymères texturants de Lubrizol Life Science et les esters de sucrose émulsifiants de Mitsubishi Chemicals complètent efficacement cette offre sur le territoire français.
\n
Sous la direction de Thierry Magnet, une équipe dynamique d’une vingtaine de personnes de formations pluridisciplinaires met tout en œuvre pour satisfaire les exigences de ses interlocuteurs, chercheurs et marketeurs. Sa priorité ? Transformer vos idées en produits pertinents.
Die Gattefossé Deutschland GmbH betreut seit 1989 Kunden der Kosmetik- und Pharmaindustrie in Deutschland und Österreich. Die deutsche Vertriebsniederlassung befindet sich in Eschbach im Gewerbepark Breisgau, der zentral im Dreiländereck Deutschland-Frankreich-Schweiz liegt.
\n
In Ergänzung zu den eigenen innovativen Produkten der Gattefossé-Gruppe vertreiben wir im Kosmetikbereich Rohstoffe unserer langjährigen Geschäftspartner Lubrizol und Mitsubishi.
\n
Das Gattefossé-Team verfügt über eine umfassende Expertise und unterstützt Sie bei der Realisierung Ihrer Pharma- und Kosmetik-Projekte. Wir teilen mit unseren Kunden unser anwendungstechnisches Know-how und garantieren eine vertrauensvolle und partnerschaftliche Zusammenarbeit.
\n
Gattefossé erkennt die Trends von morgen und entwickelt immer wieder neue Produkte und Marketingkonzepte. Die Bedürfnisse unserer Kunden stehen im Vordergrund.
\n
Das Gattefossé-Team freut sich über Ihren Anruf oder Ihre Email an: infode@gattefosse.de
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"India","name":"Gattefossé India","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"19.071948827022688","lng":"72.87676692008972"},"production_site":"Gattefossé India Pvt Ltd","address":"Equinox Business Park \r\nTower 3, 3rd floor, \r\nOff Bandra Kurla Complex, \r\nLBS Marg, MUMBAI- 400 07 \r\nINDIA \r\n \r\n+91 22 61 36 80 00","description":"
Gattefossé India is a decade run strategic supplier for cosmetics and pharmaceuticals companies in India. This Gattefossé affiliate is responsible for sales, marketing and technical service support throughout the Indian subcontinent. It sustains a profitable operation, supported by a professional team of business development, technical and customer service as well as administration managers. Gattefossé India extends extensive regulatory, toxicological support, technical and application guidance to the pharmaceutical and personal care customers. Various workshops, texture showcase and seminars are organised by experts for detailing benefits of Gattefossé products.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Italy","name":"Gattefossé Italia ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"45.5059935026097","lng":"9.1636423766613"},"production_site":"Gattefossé Italia S.R.L.","address":"Via G. Durando 38 \r\nI-20158 MILANO MI \r\nITALY \r\n \r\n+39 02 49 54 29 50","description":"
Gattefossé Italia è stata fondata nel 1960 per servire le Industrie Cosmetiche e Farmaceutiche Italiane. Dalla sua creazione, questa filiale ha conosciuto una costante crescita, dimostrando di possedere le competenze giuste per consolidare Gattefossé quale fornitore di soluzioni innovative, con ingredienti sempre più efficaci. Il nostro team di specialisti (marketing, tecnici, customer service), totalmente dedicato al servizio dei nostri clienti, opera dai nostri uffici di Milano col pieno supporto dei nostri Uffici e Laboratori Centrali di Lione e Parigi.
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","production_site"],"type":"affiliate","country":"Singapore","name":"Gattefossé Asia Pacific","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"1.3310498636538042","lng":"103.74185800552368"},"production_site":"Gattefossé Asia Pacific Pvt Ltd","address":"8 Jurong Town Hall Road \r\nThe JTC Summit, Unit 28-04 \r\nSINGAPORE 609434 \r\n \r\n+65 63 16 63 12","description":"
Gattefossé Asia Pacific, Singapore regional office is one of the latest setup within the Gattefossé group. The new entity with a core team of technical and commercial staff reinforces Gattefossé’s presence in the Asia Pacific region. The Singapore regional office works closely with distributors and logistics partners in the marketplace. The company identifies the need to evolve its operations to gain more speed and efficiency by making inroads into the South East Asian countries, Japan, South Korea, Taiwan as well as Australia and New Zealand. This enables Gattefossé to effectively service the customers in terms of technical support and commercial requirements for both Personal Care and Pharmaceutical businesses in this important region.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Spain","name":"Gattefossé España ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"40.431099512795356","lng":"-3.671826124191284"},"production_site":"Gattefossé España S.A.","address":"C/Padilla, 73, 1°B \r\n28006 MADRID \r\nSPAIN \r\n \r\n+34 9 1 402 13 11 / 1612","description":"","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Tunisia","name":"Gattefossé Mediterranean ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"36.84457343098993","lng":"10.275282561779022"},"production_site":"Gattefossé Mediterranean SCI","address":"Immeuble les Emeraudes, bloc A \r\nAvenue de la Bourse \r\nLes Jardins du Lac II \r\n1053 Tunis \r\nTUNISIA \r\n \r\n+ 216 71 192 401 / 402","description":"
The Gattefossé Mediterranean affiliate is led by Mr Fayçal El Aouni and has its regional hub in Tunis. This affiliate allows the group to consolidate its presence in North Africa and the Middle East by marketing its products to customers directly as well as offering technical support and expertise to local distributors. With this regional organisation, Gattefossé is strengthening its presence among pharmaceutical and cosmetics companies in these countries by offering them the benefit of its formulation expertise.
Gattefossé UK was established in 2001 to service Personal Care and Pharmaceuticals industries in the United Kingdom and Ireland. Since its creation, this unit has enjoyed a permanent growth and has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Our specialized team of professionals (marketing and technical support, customer service) is fully committed to servicing our customers from our Corporate Office in Berkshire. Gattefossé UK also distributes Personal care ingredients from Lessonia and Mitsubishi.
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"USA","name":"Gattefossé USA","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"40.934459736905126","lng":"-74.07849311828613"},"production_site":"Gattefossé USA Corporation","address":"Plaza I, 115 West Century Road \r\nSuite 340 \r\nPARAMUS, New Jersey 07652 \r\nUSA \r\n \r\n+1 201 265 48 00","description":"
The USA and Canadian affiliates of Gattefossé (created respectively in 1982 and 1997) were established to provide local service and support to the.pharmaceutical and personal care industries in North America. Since its creation, Gattefossé North America has enjoyed continuous growth, expanding its presence as a provider of innovative solutions involving performance ingredients. Under the leadership of Eric Brun, Ph. D, a specialized team of professionals, including marketing, customer service, supply chain, quality, and technical support, is fully committed to servicing customers from the corporate offices in Paramus, NJ, Toronto, ON and Montreal, QC. Local service is also provided by long-term partners in the US Midwest and West Coast, as well as Mexico. Today, Gattefossé has 34 employees and 3 offices in North America as well as 3 warehouses in Edison (NJ), La Mirada (CA) and Toronto (Canada).
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Egypt","name":"ENG PHARMA for Commercial Agencies","event_link":"https://www.gattefosse.com/foundation-expertise/pharmaceuticals-content/enhancing-oral-bioavailability-of-cbd-formulation-with-surfactant/","position":{"address":"","lat":"30.05029940350868","lng":"31.200098991394043"},"production_site":"ENG PHARMA for Commercial Agencies","address":"8 Kasr El Nil Street - P.O. Box 1379 \r\nAtaba - Cairo \r\nEGYPT \r\n \r\n+20 2 574 06 61 / 577 08 37","description":"","image":false,"zone":"africa_middle_east","website":""},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Morocco","name":"TOBI CONSULT","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"33.424719438185036","lng":"-7.843618333427003"},"production_site":"TOBI CONSULT","address":"Lotissement Ryad Sahel \r\nLot 1113 \r\nCP 26400 \r\nBP 264 Had Soualem \r\nMOROCCO \r\n \r\n+212 5 22 96 37 35 \r\n","description":"","image":false,"zone":"africa_middle_east","website":"http://www.orkila.com"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"South Africa","name":"CARST & WALKER ","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-26.1804449666325","lng":"28.031262159347534"},"production_site":"CARST & WALKER","address":"Office 203 Howard Terraces \r\ncnr Howard and Forest Drive \r\nPinelands 7430 (Cape Town) \r\nSOUTH AFRICA \r\n \r\nTel: +27 21 506 4567","description":"","image":false,"zone":"africa_middle_east","website":"http://www.carst.co.za"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Tunisia","name":"S.M.P.C.","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"36.85712393270689","lng":"10.20554780960083"},"production_site":"S.M.P.C.","address":"22 rue 8605, Z.I. de la Charguia \r\n2035 Tunis Carthagge \r\nTUNISIA \r\n \r\nTel :+216 71 770 166 \r\n+216 71 7770382","description":"","image":false,"zone":"africa_middle_east","website":""},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Mexico","name":"QUIMICOS LYONTEC","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"19.337618597560134","lng":"-99.13369953632355"},"production_site":"QUIMICOS LYONTEC","address":"Calle Ricardo Monges López #40 \r\nCol. Petrolera Taxqueña \r\nAlcaldía Coyoacán, \r\nC.P. 04410, CDMX \r\nMEXICO \r\n \r\nTel : +55-63869032 \r\n","description":"","image":false,"zone":"america","website":"http://www.lyontec.com"},{"section":["personal_care"],"type":"distributor","country":"Argentina","name":"DALTOSUR","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-34.56359223884317","lng":"-58.45388263463974"},"production_site":"Daltosur","address":"Vuelta de Obligado 1878 - Piso 11 \r\nOf. A- C1428ADB 6 Cdad A de Bs.As. \r\nARGENTINA \r\n \r\n+54 11 4786 7222","description":"","image":false,"zone":"america","website":"http://www.daltosur.com"},{"section":["pharmaceuticals"],"type":"distributor","country":"Argentina ","name":"MCassab Argentina S.A","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-34.49509540322527","lng":"-58.546355813741684"},"production_site":"MCassab Argentina S.A","address":"Arias 1639 “5°B” \r\n(1429) C.A.B.A \r\nARGENTINA \r\n \r\n+54 11 4703-1960 \r\n","description":"","image":false,"zone":"america","website":"https://www.mcassab.com.ar/"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Bolivia","name":"Mathiesen Bolivia","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-16.97274101999901","lng":"-63.45703125"},"production_site":"Mathiesen Bolivia","address":"Oficina regional Calle David Garzón 280, esquina Av. Vásquez, zona Pura, \r\nLa Paz, \r\nBOLIVIA \r\n \r\n+591 2 245 8222 ","description":"","image":false,"zone":"america","website":"https://www.grupomathiesen.com/es/pais/bolivia/"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Brazil","name":"M.CASSAB COMERCIO E INDUSTRIA ltda","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-23.666183680447386","lng":"-46.70869588851929"},"production_site":"M.CASSAB COMERCIO E INDUSTRIA ltda","address":"Av.das Naçoes Unidas, n.20.882 \r\nNeighbourhood:Jurubatuba \r\nSao Paulo-SP \r\nCEP 04795-000 \r\nBRAZIL \r\n \r\n+ 55 112162 7627 \r\n \r\n","description":"","image":false,"zone":"america","website":"http://www.mcassab.com.br"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Chile","name":"MATHIESEN S.A.C","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-33.392143593297014","lng":"-70.61940908432007"},"production_site":"MATHIESEN S.A.C","address":"Av. Del Parque 4265, Piso 3 \r\nCiudad Empresarial – Huechuraba \r\nSantiago \r\nCHILE \r\n \r\n+56 2 640 56 00","description":"","image":false,"zone":"america","website":"http://www.grupomathiesen.com"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Colombia","name":"MCassab Colombia S.A.S.","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"4.654824475916722","lng":"-74.05623831928277"},"production_site":"MCassab Colombia S.A.S.","address":"Av. Chile Carrera 7 No. 71-21 Torre B Piso 13 \r\nBogotá \r\nColombia \r\n \r\n+57 3114524055","description":"","image":false,"zone":"america","website":"https://www.mcassab.com.br/en/"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Ecuador","name":"Mathiesen Ecuador","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-1.0546279422758742","lng":"-78.75"},"production_site":"Mathiesen Ecuador","address":"Pasaje El Jardin Nº 168 Y Av. 6 de Diciembre Ed. \r\nCentury Plaza 1, Of 15 QUITO \r\nEcuador Cp 170515 \r\n \r\n+59 3 2333 3531","description":"","image":false,"zone":"america","website":"https://grupomathiesen.com./es/pais/ecuador/ "},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Guatemala","name":"FLOSAN SA","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"14.594028673876174","lng":"-90.52159309387207"},"production_site":"FLOSAN SA","address":"Avenida Hincapié 7-87 zona 13, \r\nCiudad de Guatemala \r\n01013 \r\nGUATEMALA \r\n \r\n+502 2301-1895","description":"","image":false,"zone":"america","website":"http://www.flosan.com.gt"},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Paraguay","name":"INSUQUIM","event_link":"https://www.gattefosse.com/foundation-expertise/corporate-events/events/","position":{"address":"","lat":"-25.29928906619203","lng":"-57.55290448665619"},"production_site":"INSUQUIM","address":"V. 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When powder properties are unsuitable for direct compression, a granulation step is required to improve compactibility, flow, and content uniformity.
\n
Lipid excipients are commonly used in two granulation techniques to modify drug dissolution, either as sustained-release or wetting agents:
\n
\n
wet granulation—where the solid lipid excipient is used in the powder blend or incorporated into the binder solution
\n
melt granulation—where the lipid excipient acts as a binder between the solid particles (ingredients are blended as temperature is brought gradually up to the lipid melting point to form granules)
\n
\n
\n
Advantages of lipid excipients in wet granulation:
\n
\n
organic solvent–free process
\n
water-insoluble atomized powders prevent swelling and sticking during granulation
\n
waxy, water-dispersible Gelucires incorporated into aqueous binder solution
\n
easy cleaning of equipment and tooling
\n
\n
Advantages of lipid excipients in melt granulation:
\n
\n
solvent-free process
\n
high binding capacity, yielding resistant granules
\n
flexible process, suitable for high shear mixer, melt extruder, and fluid bed granulator
\n","box_links":[],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/usa-pharma-events/pharmaceuticals-special-content/publications-on-granulation/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/pages/2889"}],"collection":[{"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/comments?post=2889"}],"version-history":[{"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/pages/2889/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/media?parent=2889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/categories?post=2889"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/usa-pharma-events/wp-json/wp/v2/tags?post=2889"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"publications-solid-lipid-nanoparticles":{"id":6592,"date":"2017-10-03T11:32:31","date_gmt":"2017-10-03T09:32:31","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=6592"},"modified":"2022-03-16T13:20:33","modified_gmt":"2022-03-16T11:20:33","slug":"publications-solid-lipid-nanoparticles","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-special-content/publications-solid-lipid-nanoparticles/","title":{"rendered":"Publications on solid lipid nanoparticles"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on solid lipid nanoparticles | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on solid lipid nanoparticles."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on solid lipid nanoparticles","introduction":"","":false,"content":[{"wysiwyg":"
Lipid-based nanocarriers for oral delivery of peptides
Solid lipid Nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is my peptide?
\n
Camille Dumont, Ana Beloqui, Cédric Miolane, Sandrine Bourgeois, Véronique Préat, Hatem Fessi, Vincent Jannin
\n
International Journal of Pharmaceutics, Volume 586, 30 August 2020
\n
This study aimed to evaluate the potential of Hydrophobic Ion Pairing combined with Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) to improve peptide transport across the intestinal border using Caco-2 cell monolayers (enterocyte-like model) and Caco-2/HT29-MTX co-cultured monolayers (mucin-secreting model).
\n
This study showed that hydrophobic ion pairing enabled high encapsulation efficiency of peptide in SLN and NLC. The lipid-based nanocarriers were highly internalized by Caco-2 cell monolayers and were able to cross the mucus barrier (Caco-2/HT29-MTX cell model). However, the peptide intestinal transport was limited by an extensive release from the carriers.
Solid lipid nanocarrier development toolbox for increasing oral bioavailability of API
\n
Dr Camille Dumont
\n
American Pharma Review, May-June 2020 issue, pp 69-75
\n
In this comprehensive article, the author describes the latest tools available to develop solid lipid nanoparticles: how to prepare and characterize solid lipid nanoparticles, how to evaluate encapsulation efficiency and intestinal permebility.
Journal of Drug Delivery Science and Technology (article in press)
\n
In this study, the authors developed a protocol to produce reproducible solid lipid nanoparticles by high pressure homogeneization. The possibility to encapsulate peptides was also investigated.
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
\n
Camille Dumont, Sandrine Bourgeois, Hatem Fessib, Pierre-Yves Dugas, Vincent Jannin
\n
International Journal of Pharmaceutics, Volume 565, 30 June 2019, Pages 409-418
In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal tract
\n
Dumont C., Jannin V., Beloqui A., Préat V., Fessi H.c, Bourgeois S.
\n
In this study the authors obtained solid lipid nanoparticles using high pressure homogeneization, in which leuprolide was included as an ion pair. The nanoparticles were shown to be internalized by Caco-2 and Caco-2/HT29-MTX cell monolayers.
Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation
\n
Published online October 2017
\n
European Journal of Pharmaceutical Sciences , Volume 111, 1 January 2018, Pages 91-95
\n
In this study, solid lipid nanoparticles (SLN) of glyceryl dibehenate are produced by two methods and evaluated for digestion using the in vitro lipolysis test.
\n
\n
By ultrasonication, SLN have a mean particle size of 180 nm and showed a limited digestion by lipase.
\n
By spray-flash evaporation, SLN particle size ranges from 235 to 411 nm, depending on process conditions and were not digested by lipase.
\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/6592"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=6592"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/6592/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=6592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=6592"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=6592"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"oral-peptide-delivery-with-lipid-excipients":{"id":6910,"date":"2017-11-06T12:09:12","date_gmt":"2017-11-06T10:09:12","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=6910"},"modified":"2019-10-28T09:22:13","modified_gmt":"2019-10-28T07:22:13","slug":"oral-peptide-delivery-with-lipid-excipients","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/oral-peptide-delivery-with-lipid-excipients/","title":{"rendered":"Oral peptide delivery with lipid excipients"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Oral peptide delivery with lipid excipients | Gattefossé","_yoast_wpseo_metadesc":"Discover our platform for oral peptide delivery and how lipid excipients provide solutions to the challenges of oral peptide delivery."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Oral peptide delivery with lipid excipients","content":"
The challenges of oral peptide delivery
\n
For oral peptide therapeutics to be effective, formulations must:
\n
\n
prevent peptide degradation in the gastro-intestinal tract
\n
promote peptide permeability
\n
\n
\n
Peptides need to be lipophilized to be incorporated in lipid excipients
\n
Most peptides are hydrophilic and therefore cannot be incorporated in lipid-based formulations. They need to be lipidized (i.e. increase their LogP).
\n
Hydrophobic ion pairing (HIP) is a strategy to increase the lipophilicity of peptides. Using three model peptides, a marked increase in LogP was obtained, demonstrating that HIP-peptides were lipophilic.
\n
\n
Self emulsifying drug delivery system (SEDDS): a simple and efficient solution
\n
\n
consists of a mixture of oils, surfactants and solvents designed to solubilize the drug throughout the digestion process
\n
offers an effective protection of HIP-peptide from enzyme degradation and glutathione reduction
\n
permeates through the intestinal mucus
\n
enables high HIP-peptide payload
\n
\n
Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): a promising solution \n
\n
\n
Lipid-based nanocarriers are expected to increase peptide delivery to the enterocyte, due to their nanosize which favours intracellular transport.
\n
SLN are composed of lipids in solid state at room and body temperature, usually long chain triglycerides or partial glyceride, fatty acids, waxes,etc.
\n
NLC contain both solid and liquid lipid at room and body temperature. The liquid lipids act as crystallization inhibitors of the solid lipid.
\n
\n
The nanoparticles were shown to be able to cross the mucus and the enterocyte in in vitro models.
\n
\n
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Botany is a constant source of inspiration. The diversity of plants around the world, their properties, their unique composition and their benefits to health and beauty make them a fascinating fieldwork for scientists.
\n
Developing new plant-based actives is one of the main missions of Gattefossé’s scientific team.
\n
\n
A long history
\n
\n
\n
\n
It all starts with René Maurice Gattefossé, back in the 1910s. He spent many years working on lavender fields, in Provence (France), helping the farmers to improve cultivation and distillation methods and creating the first lavender growers’ cooperative.
\n
Later, he purchased a farm in Saint-Rémy-de-Provence, thus creating an aromatic plant production and distillation center, providing his company with raw materials.
\n
\n
\n
A solid knowledge & team work
\n
\n
\n
\n
Gattefossé scientists have a strong knowledge in botany but also in phytochemistry, physiology and ecology. This allows them to select the best raw materials.
\n
The first step consists in identifying the plants of interest for a specific cosmetic application. This complex process – where chemistry, taxonomy and knowledge of customers’ requirements intersect – leads to the discovery of new botanical materials.
\n
The activity of the plant extracts that caught our attention is then evaluated in preliminary research to validate their action on specific biological targets and to ideally identifythe exact molecules responsible for this activity.
\n
Once the plant identified and validated, our team select the best sourcing, based on geographical origin, cultivation and harvesting methods, respect of the environment, shipment conditions, etc.
\n
From planting stage to harvest and shipment, all steps are controlled to ensure a responsible and sustainable supply chain, strictly following all regulations concerning access to biodiversity, fair trade and environment. Our set of specifications is clearly defined and applies for all our partners.
\n
\n
Experts in extraction
\n
\n
Green chemistry is at the heart of our processes. Depending on the plant we are working on and the results that are expected, different methods and solvents can be used to extract the active fraction in the plants:
Each process is optimized to guarantee a constant content of active molecules in each batch produced.
\n
Gattefossé has also developed a wide range of separation, purification, soaking and concentration techniques that uses ultrafiltration, distillation or chromatography.
\n
All these techniques, combined with Gattefossé’s knowledge and expertise, allow us to provide the market with high-quality ingredients.
\n
\n
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Emulium® Mellifera MB est le premier émulsionnant H/E qui s’adapte au type de peau et au climat, enveloppant la peau dans un film invisible qui la protège contre les conditions extrêmes.
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Imaginé et formulé par des équipes à travers le monde, Emulium® Mellifera MB crée des textures légères et douces d’une grande beauté et finesse. Quand la peau se sent bien, les résultats sont visibles. Hydratation, luminosité, texture et douceur, Emulium® Mellifera MB apporte la garantie d’une peau plus jeune et en meilleure santé.
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Emulium® Mellifera MB apporte une solution sensorielle aux attentes des consommateurs du monde entier, offrant du plaisir à l’application et une efficacité visible.
Au cœur de cet émulsionnant se cache un savoir-faire unique : l’association de cires naturelles et de polyglycérol végétal pour créer des beurres de cires amphiphiles aux propriétés uniques.
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Pour Emulium® Mellifera MB, le choix des chercheurs s’est porté sur les cires d’abeille et de jojoba, présentant toutes deux des caractéristiques complémentaires. Le beurre de cires ainsi obtenu est ensuite associé à du polyglyceryl-6 distearate et à de l’alcool cétylique pour optimiser ses capacités émulsionnantes et texturantes.
Emulium® Mellifera MB contient des cires végétales fonctionnalisées qui laissent un film doux et imperceptible à la surface de la peau. Ce film joue un rôle clé en aidant la peau à s’adapter à son environnement.
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Dans la nature, les cires sont connues pour protéger les plantes de la déshydratation et sans elles de nombreuses espèces ne pourraient pas survivre aux saisons. Emulium® Mellifera MB apporte ce rôle protecteur à la peau.