Transcutol® P

A high-purity solvent and powerful solubilizer associated with skin penetration enhancement in topical dosage forms.

Names and synonyms

USP NF Name

Diethylene glycol monoethyl ether

EP Name

Diethylene glycol monoethyl ether

UNII Code (FDA)

A1A1I8X02B

Preferred Substance Name (FDA)

DIETHYLENE GLYCOL MONOETHYL ETHER

Handbook of Pharmaceutical Excipients

Diethylene glycol monoethyl ether

Chemical description

Consists of highly purified diethylene glycol monoethyl ether

Key characteristics

Product form

Liquid

Viscosity (mPa.s)

4.8 (20°C)

HLB

Not applicable

Main functionalities

Solvent and powerful solubilizer.
Penetration enhancer for topical formulations.
Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved topical medicines.

Main formulation technologies

Topical gel, emulgel, emulsion, foam, microemulsion, and ointment.