Sedefos™ 75

A partially anionic oil-in-water emulsifier for topical formulations. It enables the formulation of anhydrous emulsions for hydrosensitive APIs and emulsions with solvents or large amount of oily phase.

Names and synonyms

USP NF Name

Mixture of Triceteareth-4 phosphate and
Ethylene glycol palmitostearate and
Diethylene glycol palmitostearate

EP Name

Mixture of Triceteareth-4 phosphate and
Ethylene glycol palmitostearate and
Diethylene glycol palmitostearate

UNII Code (FDA)

/
0324G66D0E
94YQ11Y95F

Preferred Substance Name (FDA)

/
GLYCOL STEARATE
PEG-2 STEARATE

Handbook of Pharmaceutical Excipients

Ethylene Glycol Palmitostearate

Chemical description

Consits of a mixture of triceteareth-4 phosphate, ethylene glycol esters of palmitic (C16) end stearic (C18) acids and diethylene glycol esters of palmitic (C16) end stearic (C18) acids

Key characteristics

Product form

Pellets

Melting range (°C)

47 –  52

HLB

10

Main functionalities

Emulsifier for anhydrous topical formulations.
Emulsifier for difficult-to-formulate emulsions (solvents and large oily phase).
Stabilizes and improves sensorial and texture properties.
Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies

Topical emulsion and foam (with aerosol).
One-pot formulation process can facilitate manufacturing.