Publications on hot melt extrusion

List of Gattefossé publications on hot melt extrusion.

Solid lipid excipients: born to be extruded!

White paper, November 2014

Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules.

These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production.

At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage.

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Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud

AAPS 2014

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Compritol® 888 ATO vs Precirol® ATO 5 in hot melt extrusion: investigation of operating window limits

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud

AAPS 2014

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Hot melt extrusion with Compritol® 888 ATO: determination of processing boundaries

Yvonne Cuppok-Rosiaux, Florence Desvignes, Jean-Michel Girard, Cédric Miolane, Delphine Marchaud

PBP 2014

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Lipid matrix by hot melt extrusion: a practical industrial solution for solid dispersion

Yvonne CUPPOK, Jean-Michel GIRARD, Helena SCHREINER, Simon SCHNABEL, Albrecht HUBER, Delphine MARCHAUD

AAPS 2012

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Preparation of hot melt extruded supersaturating solid dispersions containing glyceryl behenate: effects of processability, supersaturation and rate of release

Justin M. Keen, Justin R. Hughey, Ryan C. Bennett, Vincent Jannin and James W. McGinity

AAPS 2011

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