Plurol® Oleique CC 497

A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.

Names and synonyms

USP NF Name

Polyglyceryl-3 dioleate

EP Name

/

UNII Code (FDA)

XRQ165498B

Preferred Substance Name (FDA)

Polyglyceryl-3 oleate

Handbook of Pharmaceutical Excipients

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Chemical description

Consists of polyglyceryl-3 esters of oelic acid (C18:1), the diester fraction being predominant.

Key characteristics

Product form

Oily liquid

Viscosity (mPa.s)

3000 (20°C)

HLB

3

Main functionalities

Solubilizer for poorly-soluble APIs and bioavailability enhancer.
Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and cosurfactant for microemulsion in topical formulations.
Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies