Hard fat suppository base with high crystallization rate. Confers high mechanical resistance and yields harder suppository units.
Names & synonyms
| USP NF Name | Hard fat |
|---|---|
| EP Name | Hard fat |
| UNII Code (FDA) | 8334LX7S21 |
| Preferred Substance Name (FDA) | Fat, hard |
| Handbook of Pharmaceutical Excipients | Suppository bases, hard fat |
| Chemical description | Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant |
Key characteristics
| Product form | Pellets |
|---|---|
| Melting range (°C) | 33.5 – 35.5 |
| Hydroxyl value (mg KOH/g) | 5 – 15 |
Main functionalities
Base recrystallizes rapidly and produces harder suppository units with high mechanical resistance.
Main formulation technologies
Resources
Associated content
Hard fats for suppositories
If not always popular, suppositories remain an ultimate dosage form, when the…