Hard fat suppository base comprising polyoxylglyceride esters to enhance drug solubility and bioavailability.

Names & synonyms



EP Name


Preferred Substance Name (FDA)
Handbook of Pharmaceutical Excipients

Saturated polyglycolysed glycerides

Chemical description

Consists of of mono, di- and triglycerides and PEG mono- and di- esters of saturated fatty acids

Key characteristics

Product form


Melting range (°C)

33 - 35

Hydroxyl value (mg KOH/g)

30 - 60

suppocire ap thermorheogram

Main functionnalities

Optimized for solubility and bioavailability enhancement of poorly soluble APIs.

Main formulation technologies

Suppository molding.

Associated content

Hard fats for suppositories

If not always popular, suppositories remain an ultimate dosage form, when the…

Alternative dosage forms for rectal and vaginal drug delivery

  • Formulation technologies

If solid dosage units, i.e. suppositories and pessaries, are very frequent for…