A glyceride with an intermediate melting point used as lubricant and flow aid in powder blends for capsule filling and as a coating agent for taste masking.
Names & synonyms
|USP NF Name||
Glycerol distearate (type I)
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
|Handbook of Pharmaceutical Excipients||
Consists of esters of palmitic (C16) and stearic (C18) acids, the diester fraction being predominant
Coating agent for taste masking. Lubricant and flow aid for capsule filling with powders. Modified release matrix former for tablets. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
Main formulation technologies
Tablet compression (direct and wet granulation). Powder-filled capsules. Melt processes: granulation, extrusion, coating, prilling, spray congealing. Nanoparticle formulation.