A nonionic water-in-oil emulsifier for topical emulsions. A PEG-free liquid emulsifier ideal for cold formulation processes with heat sensitive APIs.

Names & synonyms

USP NF Name

Polyglyceryl-3 diisostearate

EP Name

Triglycerol diisostearate

UNII Code (FDA)

46P231IQ

Preferred Substance Name (FDA)

POLYGLYCERYL-3 DIISOSTEARATE

Handbook of Pharmaceutical Excipients

/

Chemical description

Consits of polyglyceryl-3 esters of stearic (C18) acid, the diester fraction being predominant

Key characteristics

Product form

Liquid

HLB

4.5

Main functionalities

sensorial map plurol diisostearique

PEG-free W/O emulsifier for topical formulations Ideal for heat-sensitive API Stabilizes and improves sensorial and texture properties Safety of use is supported by precedence of use in approved pharmaceutical products

Main formulation technologies

Topical cream. Cold formulation process.

Associated content

Opting for the best emulsifier, as a function of the formulation

Our emulsifiers are all-in-one self-emulsifying bases, enabling the preparation of…

Developing patient-friendly textures

Improvement of topical dosage form texture and sensorial properties is an…