A lipidic vehicle used as consistency agent in topical formulations. Enhances stability by preventing phase separation and oil droplet coalescence.
Names & synonyms
| USP NF Name | / |
|---|---|
| EP Name | Propylene glycol monopalmitostearate |
| UNII Code (FDA) | F76354LMGR |
| Preferred Substance Name (FDA) | PROPYLENE GLYCOL MONOPALMITOSTEARATE |
| Handbook of Pharmaceutical Excipients | / |
| Chemical description | Consists of propylene glycol esters of palmitic (C16) and stearic (C18) acids, the monoester fraction being predominant |
Key characteristics
| Product form | Waxy solid |
|---|---|
| Melting range (°C) | 33 - 40 |
| HLB | 4 |
Main functionalities
Consistency agent for oily phase in topical formulations. Stability-improving agent. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Topical cream.
Resources
Associated content
Adjusting consistency of topical dosage forms
Besides consistency, thickeners contribute to the stability of formulations,…