A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
Names & synonyms
|USP NF Name||
Caprylocaproyl Polyoxyl-8 glycerides
Caprylocaproyl macrogol-8 glycerides
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
PEG-8 CAPRYLIC/CAPRIC GLYCERIDES
|Handbook of Pharmaceutical Excipients||
Consists of a small fraction of mono-, di- and triglycerides and mainly PEG-8 (MW 400) mono- and diesters of caprylic (C8) and capric (C10) acids
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility. Safety of use is inferred by extensive toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Soft/hard gelatin capsule filling.