Expanding Your Tablet Lubrication Toolbox: Addressing Common Challenges

Tablet lubricants play a key role in pharmaceutical manufacturing, affecting everything from compression behavior to tablet performance and regulatory compliance. If you’ve ever faced challenges with API compatibility, over-blending, or mitigating nitrosamine risks, it may be time to explore safer, more robust alternatives.

This in-depth whitepaper discusses common challenges in tablet lubrication and introduces Compritol® 888 ATO (glyceryl dibehenate)—a proven, nitrosamine-free lubricant that simplifies formulation development and improves batch-to-batch consistency from R&D through commercial scale-up.

What You’ll Learn:

• Key differences between common families of lubricants
• Common pitfalls in tablet lubrication—including API degradation, poor dissolution, and blending sensitivity
• How Compritol® 888 ATO (glyceryl dibehenate) delivers low ejection forces, consistent tablet properties, and regulatory peace-of-mind
• Case study: a comparative study evaluating Compritol® vs. alternative tablet lubricants

Whether you’re developing a new oral solid dosage form or reformulating to meet evolving regulatory standards, this resource offers practical guidance grounded in real data.