Publications on taste-masking
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Yvonne Rosiaux, Amandine Forest, Jean-Michel Girard, Carole Deleglise, Liz Sheehan and Delphine Marchaud
Journal of Drug Delivery Science and Technology 48 (2018) 437–449
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking
HIGH SHEAR COATING:
A VERSATILE TASTE-MASKING PROCESS
C Morin and Y Rosiaux
Taste-masked drugs for pediatric medicines through lipid coating
Rosiaux Y., Forest A., Girard J.M., Deleglise C., Marchaud D.
AAPS 2017
Efficient taste masking through high shear coating
Rosiaux Y., Forest A., Girard J.M., Deleglise C., Marchaud D.
EuPFI 2017
