Publications on Labrasol®

Labrasol^® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies

Fiona Mc Cartney, Vincent Jannin, Stéphanie Chevrier, Hakime Boulghobra, Delyan R. Hristov, Nicolas Ritter, Cédric Miolane, Yann Chavant, Frédéric Demarne, David J. Brayden

In this study Labrasol^® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.

Labrasol^® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers  across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.

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Investigation of Labrasol^® ALF as an intestinal permeation enhancer: Ussing chambers and intestinal instillations

Labrasol^® acts an intestinal permeation enhancer ex vivo

McCartney, F., Jannin, V., and Brayden, D.J.

UCD Conway Festival of Research and Innovation (October 2018)
Winner of personalised medicine category

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Labrasol^® is an efficacious non-damaging intestinal permeation enhancer in isolated rat intestinal mucosae

Fiona McCartney, Vincent Jannin and David J. Brayden

CRS 2018 poster

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Investigation of Labrasol^® ALF and its components as intestinal permeation enhancers in rat tissue in the Ussing chamber system.

McCartney, F., Jannin, V. and Brayden, D.J. I

UK & Ireland Controlled Release Society Symposium, Belfast (June 2018).

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Investigation of derivatives of Labrasol® as permeation enhancers across rat intestinal tissue mucosae ex vivo.

McCartney, F., Jannin, V., and Brayden, D.J

11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain
March 2018

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