Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
Fiona Mc Cartney, Vincent Jannin, Stéphanie Chevrier, Hakime Boulghobra, Delyan R. Hristov, Nicolas Ritter, Cédric Miolane, Yann Chavant, Frédéric Demarne, David J. Brayden
In this study Labrasol® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.
Labrasol® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.
Access the publication