Children are very sensitive to bitterness, due to a higher number of specific buds on the tongue. Therefore masking the taste of drugs is essential for pediatric medicines.
Coating technologies with lipid excipients enable the formation of a film coat around the drug particles to mask their taste. The coated drug particle is further used for granules, tablets and capsules.
High shear coating is achieved in a high shear mixer, without external heating, and partial melting of Precirol® ATO 5. This simple, efficient and robust process was successfully used with KCl, isoniazid, paracetamol and ranitidine HCl as model drugs.
Hot melt coating is achieved in a fluid bed coater and full melting of Precirol® ATO 5.
Access our publications on taste masking.