Masumi Dave, Reena Rahi and Jasmine Musakhanian
PharmSci AAPS 2022
The purpose of this study was to evaluate and demonstrate that a methodical approach can help streamline the process of formulation development with lipid-based excipients. Accordingly, a series of formulations were developed by combining lipid-based excipients (surfactant, co-surfactant, and oil/co-solvent) using fenofibrate as a model drug. The effect of changing formulation composition, role of fatty acid chain length, and excipient HLB were evaluated using in vitro performance testing methods.
Masumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph.
AAPS 2017
Jannin, Vincent; Benhaddou, Hamza; Dumont, Camille; Chevrier, Stéphanie; Chavant, Yann; Demarne, Frédéric
AAPS 2014
Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013).
AAPS Annual Meeting and Exposition. San Antonio, 2013.
Solubility screening is detailed in both liquid and (semi) solid excipients, to select excipients with highest solubilizing capacity.
Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)
AAPS Annual Meeting and Exposition. San Antonio, 2013.
Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations
Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)
AAPS Annual Meeting and Exposition. San Antonio, 2013.
Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state.