Solubility and bioavailability enhancement
Lipid-based drug delivery (LBDD) systems are increasingly used to overcome poor drug solubility and improve oral bioavailability. As a pioneer in the field of self-emulsifying and self-microemulsifying drug delivery systems (SEDDS and SMEDDS), Gattefossé has put much work into the development of formulation strategies and characterization methodology. Our customers benefit from our Formulation Guidelines, training, and one-to-one advice on LBDD development.
Lipid excipients enable the straightforward development of sustained-release matrices with high physiological resistance. Our case studies address a range of APIs and formulation through various processes (e.g., direct compression, wet/hot granulation, and hot melt extrusion). Certain APIs have been the focus of scale-up operations and human in vivo studies. Customers may have access to our Formulation Guidelines and practical tips for the development of robust SR formulations.
Sensorial texture improvement
Gattefossé emulsifiers enable the development of simple topical formulations with the texture and sensorial quality of cosmetic products. Our prototype formulations are subject to in-house sensorial analysis through which we learn how to optimize texture and sensorial aspects by appropriate selection of excipients and formulation. Customers have access to our data bank of prototype formulations and technical support to develop superior products.
The development of topical formulations allowing targeted transcutaneous drug penetration is a challenge. We have studied the solubilizing capacity of our excipients in conjunction with specific APIs and developed skin-penetrating formulations subject to industry-standard in vitro tests.
Decades of experience in suppository formulation and specialized analytical equipment enable us to develop robust suppositories with excellent drug delivery properties. Our formulation data bank, ability to match APIs with appropriate suppository or pessary bases, and expertise in scale-up and production mean we can help customers develop new products, or reformulate existing ones faster.