Names and synonyms
USP NF Name
Polyglyceryl-3 dioleate
EP Name
/
UNII Code (FDA)
XRQ165498B
Preferred Substance Name (FDA)
Polyglyceryl-3 oleate
Handbook of Pharmaceutical Excipients
/
Chemical description
Consists of polyglyceryl-3 esters of oelic acid (C18:1), the diester fraction being predominant.
Key characteristics
Product form
Oily liquid
Viscosity (mPa.s)
3000 (20°C)
HLB
3
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion, and foam.
