Names and synonyms
USP NF Name
Glyceryl monooleate (Type 40)
EP Name
Glycerol mono-oleates (Type 40)
UNII Code (FDA)
4PC054V79P
Preferred Substance Name (FDA)
GLYCERYL OLEATE
Handbook of Pharmaceutical Excipients
Glyceryl monooleate
Chemical description
Consists of mono-, di- and triglycerides of oleic (C18:1) acid, the monoester fraction being predominant
Key characteristics
Product form
Liquid
Viscosity (mPa.s)
220 (20°C)
HLB
1
Main functionalities
Solubilizer for lipophilic APIs and bioavailability enhancer. Oily vehicle containing long-chain fatty acids (C18:2) for LFCS Type I (oily), Type II (SEDDS), and Type III (SMEDDS), associated with lymphatic absorption. Oily vehicle for topical formulations. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
Main formulation technologies
Soft and hard gelatin capsule filling. Topical emulgel and ointment.
