Names and synonyms
USP NF Name
Caprylocaproyl Polyoxyl-8 glycerides
EP Name
Caprylocaproyl macrogol-8 glycerides
UNII Code (FDA)
00BT03FSO2
Preferred Substance Name (FDA)
PEG-8 CAPRYLIC/CAPRIC GLYCERIDES
Handbook of Pharmaceutical Excipients
Polyoxylglycerides
Chemical description
Consists of a small fraction of mono-, di- and triglycerides and mainly PEG-8 (MW 400) mono- and diesters of caprylic (C8) and capric (C10) acids
Key characteristics
Product form
Liquid
Viscosity (mPa.s)
80 – 110 (20°C)
CMC (mg/L, 25°C)
42 ±24
HLB
12
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility. Safety of use is inferred by extensive toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
