Names and synonyms
USP NF Name
Linoleoyl Polyoxyl-6 glycerides
EP Name
Linoleoyl Macrogol-6 glycerides
UNII Code (FDA)
1U4409FY0P
Preferred Substance Name (FDA)
CORN OIL PEG-6 ESTERS
Handbook of Pharmaceutical Excipients
Polyoxylglycerides
Chemical description
Consists of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of linoleic (C18:2) acid
Key characteristics
Product form
Liquid
Viscosity (mPa.s)
70 – 90 (20°C)
HLB
9
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS). Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
