Names and synonyms
USP NF Name
Glyceryl Mono and Dicaprylocaprate
[NOTE – May also be labeled as USP Glyceryl Monocaprylocaprate (Type I) until May 1, 2025]
EP Name
Glycerol monocaprylocaprate (type I)
UNII Code (FDA)
U72Q2I8C85
Preferred Substance Name (FDA)
GLYCERYL MONO AND DICAPRYLOCAPRATE
Handbook of Pharmaceutical Excipients
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Chemical description
Consists of mono- and diglycerides of caprylic acid (C8) and capric acid (C10), the monoester fraction being predominant
Key characteristics
Product form
Liquid
Viscosity (mPa.s)
120 (20°C)
HLB
5
Main functionalities
Solubilizer of poorly-soluble APIs, intestinal permeation enhancer of poorly permeable drugs and oral bioavailability enhancer. Water insoluble surfactant used in lipid-based formulations Type I (oily solutions), Type II (SEDDS) and Type III (SMEDDS) formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
