Names and synonyms
USP NF Name
Propylene Glycol Monocaprylate NF
[May also be labeled as Propylene Glycol Monocaprylate (type II) NF until December 1, 2026]
EP Name
/
UNII Code (FDA)
RT9P9S09QI
Preferred Substance Name (FDA)
PROPYLENE GLYCOL CAPRYLATE
Handbook of Pharmaceutical Excipients
Propylene glycol monocaprylate
Chemical description
Consists of propylene glycol esters of caprylic acid (C8), mainly composed of monoesters and a small fraction of diesters.
Key characteristics
Product form
Oily liquid
Viscosity (mPa.s)
20 (20°C)
HLB
5
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion.
