Gattefosse case studies for Pharmaceuticals

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How to select the best permeation enhancer for benzoylaconitine transdermal patch?

Due to the high molecular weight of Benzoyl Aconitine (603.7), formulating a transdermal patch is a challenge. Among all the tested permeation enhancers, Plurol^® Oleique CC 497 showed the best results.

Keywords: transdermal patch, Benzoyl Aconitine, Plurol^® Oleique CC 497, FT-IR analysis

Fenofibrate tablets with Gelucire® 44/14

The aim of this study was to prepare tablets by wet granulation using Gelucire^® 44/14 to improve the dissolution of fenofibrate.

Keywords: tablet, wet granulation, fenofibrate, Gelucire^® 44/14

How to formulate a daphnetin transdermal patch with enhanced permeation?

The aim of the study was to develop an optimized drug-in-adhesive patch with 1% daphnetin with good in vitro drug release and skin permeation. Backing films, permeation enhancers and permeation enhancer content were investigated through in vitro experiments.

Keywords: transdermal patch, daphnetin, Transcutol^® P

Are lipid excipients suitable for 3D printing?

The feasibility of preparing solid SEDDS using solid (Gelucire® 48/16) and semi-solid (Gelucire® 44/14) lipid excipients with a 3D printer is assessed using two model drugs, i.e. cinnarizine and fenofibrate.

Keywords: 3D printing, Gelucire^® 44/14, Gelucire^® 48/16, fenofibrate, cinnarizine

How to obtain sustained release tablets of metformin hydrochloride by direct compression ?

The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).

Keywords: dual matrix, sustained release, metformin hydrochloride, Compritol^® 888 ATO, HPMC, direct compression, high drug load

How to reduce drug release variability in HPMC-based sustained-release tablets ?

The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.

Keywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol^® 888 ATO

How to formulate a simple emulgel with a high level of Transcutol® P

In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.

Keywords: Emulgel, Transcutol^®, Gelot™64, Emulcire^® 61 WL 2659, stability, viscosity, pH