What You Should Know About Lipid-Based Formulations:
Oral Delivery of Peptides

July 16, 2017
9:00-10:00 a.m.
Convention Center, Room E

Oral administration of peptides is challenged by a number of physiological barriers including presystemic degradation by proteases, deactivation by reduced glutathione, and poor intestinal membrane permeability. Lipid formulations, notably self-emulsifying drug delivery systems (SEDDS), can successfully overcome these challenges.

In an interesting series of recently published works, model peptides leuprorelin, insulin and desmopressin were formulated in SEDDS following hydrophobic ion-pairing of the peptides. The newly designed formulations facilitated payloads of >10% for peptide drugs, provided 100% protection against proteases, and reduced glutathione, and improved their intestinal permeability.

This session shares the intricacies and the promising results of the aforesaid work.

Speakers:

Vincent Jannin HDR (Dir. R&D Projects)
Jasmine Musakhanian, M.Sc. Scientific and Marketing Dir

For all registered attendees, this event is complimentary. Gattefossé will also be exhibiting at Booth 404 in the main hall.

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