Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
E. Dauphin-Chanard ; A. Forest ; C. Deleglise ; D. Hoste ; P. Caisse
Gattefossé SAS – Saint-Priest – France
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
Masumi Dave ; Jasmine Musakhanian ; Jason LePree and Rollie Fuller
Gattefossé USA – Paramus – USA
Gelucire® 48/16: a safe wetting agent for tablet. A case study with fenofibrate
E. Dauphin-Chanard ; JM. Girard ; C. Deleglise ; P. Caisse
Gattefossé SAS – Saint-Priest – France
Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers
Fiona McCartney ; Camille Dumont ; Philippe Caisse and David J. Brayden
University College Dublin
Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets
Agnivesh Shrivastava ; Renuka Tiwari ; Ketkee Deshmukh and Sunil Bambarkar
Gattefossé India – Mumbai – India
An optimized LBF enables solubilization of the entire therapeutic dose and maintains the drug in solubilized state throughout the digestion process.
\nTo speed up LBF development, we have produced tools to guide you at each stage of development:
\n1 – methods for saturation solubility screening
\n2 – database of solubility of drugs in common pharmaceutical excipients
\n3 – methods for miscibility and dispersability testing
\n4 – miscibility table
\n5 – in vitro lipolysis procedure
\n6 – guideline for preclinical studies
\nTranscutol® CG is a powerful solubilizer and efficacy booster that has been used in the cosmetic and pharmaceutical industries for decades. The reasons for its success lie in its recognized solvent and efficacy-boosting qualities, exceptional safety, and versatility of use.
\n","use_level":"2-30%*","naturalite":"","inci":"Ethoxydiglycol","origin":"Transcutol® CG has been used in the pharmaceutical industry for over 40 years and has an excellent safety profile. *Restricted use levels in Europe:
\nE Dauphin-Chanard, D Hoste and D Marchaud Poster – PBP 2018
\n\n"},{"wysiwyg":" Access our publications on pharmaceutical foams
E Dubois, E Dauphin-Chanard, D Hoste and D Marchaud Poster – AAPS 2008
\n\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/9032"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=9032"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/9032/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=9032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=9032"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=9032"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"labrafac-lipophile-wl-1349":{"id":3231,"date":"2017-04-26T09:46:56","date_gmt":"2017-04-26T09:46:56","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3231"},"modified":"2021-12-16T11:58:57","modified_gmt":"2021-12-16T09:58:57","slug":"labrafac-lipophile-wl-1349","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-products/labrafac-lipophile-wl-1349/","title":{"rendered":"Labrafac™ lipophile WL 1349"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[7],"tags":[],"acf":{"component":"PageProductPharma","":false,"product_codes":[{"code":"3139"}],"product_image":{"id":13616,"alt":"","title":"liquid","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1.jpg","width":1716,"height":600,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"product_title":"Labrafac™ lipophile WL 1349","introduction":"An oily vehicle and solubilizer of lipophilic APIs for oral and topical lipid-based formulations (LBFs).
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engagements de Gattefossé| Des ingrédients de qualité et une politique d'innovation responsable","_yoast_wpseo_metadesc":"Notre politique d'innovation nous pousse à porter une attention constante au développement de nos produits pour en minimiser l'impact sur l'environnement. "},"categories":[30],"tags":[],"acf":{"component":"PageExpertiseCorpo","title":"Engagements ","introduction":"Nous nous engageons vis-à-vis de la planète, de nos clients et de nos partenaires à réduire notre empreinte globale et à toujours encourager des rapports humains durables et éthiques, sans jamais faire aucune concession sur la qualité de nos produits. C’est par notre volonté de partager nos connaissances et de favoriser l’innovation dans nos domaines d’activité que nous entendons faire la différence.","":false,"content":[{"wysiwyg":"\n
\n
La qualité est pour nous un facteur-clé de progrès. Elle est partie intégrante de tout ce que nous entreprenons, depuis nos activités de R&D jusqu’à la commercialisation des produits.
\nNos politiques de qualité sont constamment mises à niveau afin de répondre aux attentes de nos clients et de les anticiper. Nous sommes régulièrement audités par nos principaux clients et nous nous efforçons d’améliorer de façon continue nos normes de qualité, validées par plusieurs certifications.
\n\n
\n
\n
Nous appliquons strictement les bonnes pratiques de fabrication (BPF), que ce soit pour nos excipients pharmaceutiques ou nos ingrédients cosmétiques.
\n\n
\n
Dans le cadre de notre politique de management, nous avons mis en place des mesures de sécurité strictes visant à prévenir les risques liés à nos activités – fabrication, chaîne d’approvisionnement, logistique et R&D – et nos installations – lignes de production, laboratoires d’applications et bâtiments administratifs.
\nLa formation de nos équipes fait l’objet d’une attention particulière de notre part et passe notamment par des campagnes de sensibilisation régulières. Nous définissons des indicateurs et mettons systématiquement en place des plans d’action pour assurer la sécurité de nos collaborateurs et l’innocuité de nos produits sur le long terme.
\n\n
Cet engagement en faveur de la qualité nous permet de partager des références communes avec nos clients en termes de systèmes et de normes industrielles et de les intégrer à nos propres procédures.
\n"},{"wysiwyg":"\n
\n
Pour encourager l’innovation responsable, nos processus de production ont été modernisés avec pour objectif de dépenser moins d’énergie, de réduire nos déchets et de maximiser le recyclage.
\nDepuis de nombreuses années, Gattefossé s’engage en faveur du développement durable, en réduisant sensiblement sa consommation énergétique tout en augmentant sa capacité de fabrication.
\nNotre entreprise protège l’environnement en sélectionnant avec soin des matières premières d’origine naturelle pour ses processus de production. Ainsi, Gattefossé est membre depuis 2010 de l’organisation RSPO qui soutient les coopératives et les producteurs d’huile de palme responsables. En 2017, l’entreprise a obtenu la certification RSPO « Mass Balance » pour son site de fabrication en France. Gattefossé utilise également une huile de palme certifiée « Segregated » pour sa gamme d’ingrédients cosmétiques Lipocire™.
\nGattefossé offre la garantie que ses matières premières proviennent de sources fiables, identifiables et renouvelables, grâce à un traçage rigoureux de leurs origines et des méthodes de production. Nous établissons avec nos fournisseurs des relations pérennes et les considérons comme de véritables partenaires stratégiques.
\n\n
\n
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Nous avons la conviction que la future croissance de notre entreprise dépend des talents qui la composent à travers le monde et qui œuvrent au quotidien pour faire de Gattefossé un acteur mondial. Le groupe est fier de sa forte culture d’entreprise, influencée par les personnalités de ses fondateurs et de ses dirigeants. Ils ont su faire évoluer la société tout en restant fidèles au code éthique établi dès sa création.
\n→ A propos de la culture d’entreprise de Gattefossé
\n"},{"wysiwyg":"\n
\n
Gattefossé a établi des liens étroits avec la communauté scientifique internationale et partage ses connaissances par le biais de publications, de séminaires et de conférences. L’entreprise soutient des doctorants et gère des projets de recherche sous contrat avec divers groupes universitaires dans le monde.
\n\n
\n
\n
\n
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Organisées sous l’égide de la Fondation Gattefossé, les Journées Galéniques de Saint-Rémy de Provence rassemblent chaque année la communauté scientifique internationale industrielle et académique autour d’un thème lié à la formulation des médicaments. Cet évènement vise à favoriser les échanges scientifiques en pharmacie galénique pour faire progresser les connaissances et les techniques dans ce domaine.
\nEn organisant ces rencontres, Gattefossé poursuit l’œuvre initiée dans les années 60 par Henri-Marcel Gattefossé, qui plaça l’entreprise sous le signe du dialogue avec les chercheurs du monde entier.
\nLes conclusions des Journées Galéniques sont publiées sous forme d’un Bulletin Technique* mis à la disposition de tous les professionnels du secteur pharmaceutique.
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These General Terms and Conditions of Use (“General Terms and Conditions of Use”) apply to the browsing of the website www.gattefosse.com (the “Website”) and the use of its features.
\nBy accessing the Website, the user (the “User”) acknowledges having read and accepted without reservation all the General Terms and Conditions of Use herein and undertakes to comply with them.
\nThese General Terms and Conditions of Use may be revised by Gattefossé at any time without any formality other than the online publication of a new amended version, the latter prevailing over any previous version.
\nThe Website is accessible free of charge in any place to any User with internet access.
\nAny costs involved in accessing the Website (computer hardware, software, internet connection, etc.) are borne by the User.
\nIn the event of maintenance work, an event beyond the control of Gattefossé, an outage or in the event of force majeure, access to the Website may be interrupted or suspended without notice or justification and without Gattefossé being held liable.
\nIn addition, Gattefossé reserves the right to interrupt or definitively cease publication of the Website, at any time, without notice or justification and without being held liable.
\nAny User who wishes to access the members’ section of the Website (the “Members’ Section”) must register by filling in the form.
\nWhen registering in the Members’ Section, the User undertakes to provide accurate information concerning their civil status, contact details (email address), the company for which they work, their field of activity and the position they hold there,
\nRegistration is subject to validation by Gattefossé, who are free to refuse a User’s registration, without justification and without being held liable.
\nAccess to the Members’ Section is controlled by entering the email address provided upon registration and the password selected by the User.
\nThese identifiers are strictly personal and must not be conveyed to third parties. In all events, the User remains responsible for the use made of them.
\nWithout prejudice to its other rights and remedies, Gattefossé reserves the right to suspend or delete, without notice, the account of any User who does not comply with these General Terms and Conditions of Use.
\nThe User may request that their account be deleted by sending an email to: contact@gattefosse.com specifying their first and last names, email address and the reason for their request. Account deletion will be effective within a reasonable timeframe.
\nAny deletion of an account, for any reason whatsoever, shall result in the definitive deletion of all the User’s personal information.
\nThe registered or unregistered trademarks, logos and signs represented on the Website as well as all its content (texts, icons, photographs, illustrations, layouts, etc.), including the content of the Members’ Section, are protected by the French Intellectual Property Code and more specifically by copyright.
\nAny reproduction, representation, publication, redistribution or copying of all or part of these elements is subject to the express prior authorisation of Gattefossé and/or the holders of the rights for these elements.
\nNon-compliance with this obligation may constitute an act of infringement punishable under Articles L335-2 et seq. of the French Intellectual Property Code.
\nAccess to the Website shall not be interpreted as conferring on the User any licence or intellectual property right whatsoever over the Website and/or its content other than that of viewing and browsing the Website.
\nAll Users are also prohibited from using a robot or any other automatic process that enables them to access, vacuum or extract the data contained or presented on the Website.
\nWithout prejudice to the above, any User duly registered in the Members’ Section may download the media made available in the members’ section. These media may only be used for personal and informational purposes, to the exclusion of any commercial and/or advertising use. The User shall also refrain from (i) deleting or modifying the copyright notices and any other proprietary notices affixed or contained in these media (ii) modifying or altering these media and their content (iii) publishing and distributing, in any manner whatsoever, for consideration or free of charge, these media and their content. More generally, the User shall refrain from directly, indirectly or through third parties, in any way whatsoever, infringing the rights of Gattefossé and/or the rights of third parties on these media.
\nGattefossé may collect and process personal data that Users provide during their browsing of the Website.
\nGattefossé undertakes to collect and process this data in accordance with applicable law and the provisions of its Personal Data Protection Policy.
\nWhen browsing the Website, cookies may be placed on the User’s device (computer, tablet, smartphone). A cookie is a small computer file deposited on the User’s device through their internet browser that allows certain data to be stored in order to facilitate browsing on a website and enable certain functionalities.
\nGattefossé’s use of these cookies is governed by the provisions of its Personal Data Protection Policy.
\nGattefossé does not provide any warranty, whether express or implied, concerning the Website and/or all or part of its content.
\nGattefossé will make every effort to ensure that the information presented on the Website is accurate, up-to-date and reliable, but will not be held responsible for any error or omission in this respect.
\nThe information presented on the Website is provided for information purposes only.
\nConsequently, Gattefossé may not be held liable for any damage, direct or indirect, of any kind whatsoever, resulting from the use by the User of the information presented on the Website.
\nGattefossé declines all responsibility for any viruses that may infect the User’s computer hardware due to access to, or use of, the Website.
\nGattefossé cannot be held liable for any difficulties in accessing the Website and/or disruptions to Internet connections. Similarly, the liability of Gattefossé is excluded in the event of force majeure.
\nIn general, Gattefossé declines all liability in the event of direct or indirect damage, regardless of the causes, origins, nature or consequences that would result from access to and/or use of the Website and/or its content, the User taking sole responsibility for the resulting risks.
\nThe Website may have hypertext links directing the User to other websites. Gattefossé declines all responsibility regarding access to and use of these websites and/or their content, the User alone assuming full responsibility and the resulting risks.
\nThese General Terms and Conditions of Use are governed by French law. In the event of a dispute, the courts of Lyon shall have sole jurisdiction, including in the event of summary proceedings, third-party claims or multiple defendants.
\n\n
Please find below the General Terms & Conditions of Sale (“T&C’s”) applicable to all sales of products and/or services by the corresponding affiliate of the Gattefossé Group:
\n\n
For the T&C’s applicable to sales by other Gattefossé affiliates, please contact your local sales representative.
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Definicire® is an active texturizing agent that recreates the hair protective lipid layer. 100% natural, based on functionalized jojoba and sunflower seed waxes, it ensures perfect hair discipline in all climates, and a comfortable smooth feel.
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Silicones and quaternary compounds are the main cosmetic ingredients used as hair conditioners. They are both efficient, in different ways, but have limitations regarding biodegradability, build-up effect and image. In addition, they are not natural and are unlike the complex hair lipid layer.
\nGattefossé has placed its expertise in lipid chemistry at the service of haircare.
\n Definicire® is a unique ingredient obtained by interesterification of jojoba wax and sunflower seed wax in presence of polyglycerol. Its composition has been optimized to recreate the performance of sebum and 18-MEA which are known to provide naturally the best protection of the hair.
Healthy hair is hydrophobic. Definicire® reinforces the hydrophobicity of the hair. It acts as a lubricant decreasing friction between hair fibers and improves hair quality in both dry and humid conditions.
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Hot melt extrusion is a continuous solvent-free technology with precise process control. Lipid excipients are mainly used as matrix formers for modified release, or as solubilizers for solubility/bioavailability enhancement, alone or in combination with polymers.
\n\n
Advantages of lipid excipients in hot melt extrusion:
\nRange of functional excipients for extrusion:
\n\n
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
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Discover Dermacare and learn how our pharmaceutical grade emulsifiers can be used to create an exciting range of topical dosage forms with excellent texture and sensorial properties that will delight patients.
\n\n
\n
An incredible texture for this balm, well-adapted for massage.
The thickness is brought by a subtle combination of Compritol® 888 Pellets, Geleol™ Mono and Diglecerides NF and hydrogenated castor oil.
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\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
\n\n"},{"wysiwyg":"
Interest of carriers for the development of solid self-emulsifying drug delivery systems
\nBibliography on Gattefossé’s products. 2004-2005 review.
\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
\nInterest of carriers for the development of solid self-emulsifying drug delivery systems
\nBibliography on Gattefossé’s products. 2004-2005 review.
\nDevelopment of immediate release pellets of poorly soluble compounds using Gelucire® 44/14
\nNature is a constant inspiration for cosmetics ingredients, but plants are not the only sources of natural actives. Mineral Matters™ liquid stone extracts apply special technology to extract important minerals from precious stones and make them bioavailable to the skin. The result is a unique line of substantiated stone actives that enhance and protect. Oli’Vîne™ is an energizing magnesium complex extracted from peridot. It increases cellular activity, helps skin cells fight stress, and simultaneously oxygenates and energizes the skin for an antiaging, antistress effect. See the other actives in this Mineral Matters™ line:
\n\n","use_level":"0.5-3%","naturalite":"NPA certified","inci":"Water (and)
Peridot is an ancient gemstone. An earlier term for it was chrysolite, whose Greek roots mean “golden stone,” an allusion to its gold-green brilliance. Peridot was also used in Egyptian jewelry dating to the time of the pharaohs.
\n","":false,"origin_video":"","key_benefits_carousel":[{"content":"In vitro prove Oli’Vîne™ acts effectively on the dermis and epidermis to
\nA gel formulation includes a gelling agent—carbomers, hydroxyethyl cellulose, and hydroxypropyl cellulose are the most widely used—and solubilizers. Depending on the excipients used, a gel can be transparent (most common), translucent, or opaque.
\nThe challenge when developing a gel is to keep the drug in a solubilized state and to identify the right gelling agent. Thus the selection of appropriate solubilizer is very important and must be compatible with the gelling agent.
\n\n
Transcutol® P is compatible with all types of gelling agents and can be used at a very high concentration in the gel without altering its structure. Clear gels are obtained.
\nLabrasol® is compatible with all types of gelling agents. Depending on the concentration, clear or opaque gels are obtained.
\nCapryol® PGMC produces an opaque gel when used at <6% with hydroxypropyl cellulose.
\n\n
Transcutol® P is widely used as solubilizer in gels, creams and emulgels.
\nA simple emulgel formulation with high level of Transcutol® P can be obtained.
\nLog-in to download our case study.
\n\n
\n","box_links":[],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/fr/pharmaceuticals-special-content/publications-on-transcutol/","external_link":""},{"text_link":"Discover our range of excipients for topical drug delivery","link":"https://www.gattefosse.com/fr/pharmaceuticals-range-of-products/range-of-products/","external_link":""},{"text_link":"Learn more about our solubilizers","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/excipients-for-solubilizing-drugs/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/2954"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=2954"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/2954/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=2954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=2954"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=2954"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"formulating-water-in-oil-emulsions":{"id":18303,"date":"2020-02-20T17:58:08","date_gmt":"2020-02-20T15:58:08","guid":{"rendered":"https://www.gattefosse.com/?page_id=18303"},"modified":"2021-05-19T22:29:24","modified_gmt":"2021-05-19T20:29:24","slug":"formulating-water-in-oil-emulsions","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-trend/formulating-water-in-oil-emulsions/","title":{"rendered":"Formulating W/O Emulsions w/out Worry!"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":27,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Formulating W/O emulsions can be challenging. Gain some insight on how to get started & discover Emulium® Illustro to achieve a winning W/O formulation!"},"categories":[56],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":18301,"alt":"Water in oil","title":"02.2020 - Main image article_1536x510","caption":"W/O, water-in-oil","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/02/Main-image-article_1536x510-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"component":"PageGenericContentCos","title":"Formulating W/O Emulsions w/out Worry!","description":"","content":"
\n
W/O (water-in-oil) emulsions are becoming more and more preferred in the personal care space, particularly regarding color cosmetics and sun care. In color cosmetics, W/O foundations offer better water resistance, long-wear, and high coverage – all the performance qualities a consumer desires – compared to O/W (oil-in-water) formulations. And though W/Si (water-in-silicone) formulations may offer great performance and texture, they do not qualify as natural makeup, making them a less desirable option among younger shoppers. When it comes to sun care, consumers are moving towards mineral options. Sunscreen launches containing zinc oxide increased by 45% from 2014-15 to 2018-19 in North America(1). Zinc oxide is easier to formulate in a W/O than an O/W system. In fact, most inorganic sunscreens are either anhydrous or W/O formulations.
\nHowever, formulating can be easier said than done, as there are many challenges that come with making a stable W/O product. W/O systems are more sensitive to other ingredients and require more energy in their processing to ensure stability. There are two key factors to consider when it comes to W/O formulation: oil polarity and electrolyte addition, which may not have any influence or not even be necessary for O/W formulations.
\n\n
\n The emulsifier you choose has distinctive characteristics that will help you determine the profile of your other ingredients. One trait to consider, that is often overlooked, is polarity. If you are using a more polar emulsifying agent, then your oil phase should consist of more polar oils. Some medium to high polarity oils include C12-15 alkyl benzoate, caprylic/capric triglycerides, octyldodecyl myristate, castor oil, and coco-glycerides, among countless others. On the other hand, if the emulsifier is not very polar, then your oil phase should be more comprised of apolar oils, such as alkanes like squalane, or undecane, tridecane, or silicones if preferred.
\n\n
\n
\n The stability of W/O emulsions can be improved by adding a proper concentration of inorganic salts, such as CaCl2, NaCl, MgCl2, and MgSO4, in the aqueous phase(2). Adding salts to a W/O emulsion inhibits Ostwald ripening, which is where smaller droplets diffuse and deposit themselves onto larger droplets.
\n\n Inorganic salts can also lower the interfacial tension at an oil-water interface, thereby improving stability against coalescence and sedimentation(2).
\n
\n Attractive forces exist within the dispersed phase and can increase their collision frequency(2). This can lead to either coalescence or sedimentation. However, by adding electrolytes to the system, you can lower the attractive forces between water droplets to ensure stability.
\nNeedless to say, electrolytes are absolutely necessary to ensure a stable formula, maintaining the smaller droplet sizes in a consistent, even dispersion.
\n\n
\n
Emulium® Illustro is Gattefossé’s gold-winning, naturally derived, high performing, W/O emulsifier that can help you create a natural, stable, and sensorial make-up, sun care, or skincare product! You will notice that this ingredient has a very large, polar head group and long lipophilic chains that also have polar bonds, as seen by the hydroxide and ester groups:
\n
Because of these polar properties, Emulium® Illustro is more compatible with medium to high polarity oils. But since we’ve engineered this ingredient to be highly compatible and flexible, you may still incorporate apolar oils at certain percentage levels. And as for electrolytes, our R&D team found this ingredient to work very well with 2% MgSO4 or 1% of MgSO4 and NaCl. Check out this video to see how you can make a 2-min emulsion using Emulium® Illustro!
\n\n
\n
\n
\n
(1) Mintel GNPD
\n(2) Qiaomei Zhu, Yijun Pan, Xin Jia, Jinlong Li, Min Zhang, Lijun Yin. Review on the Stability Mechanism and Application of Water‐in‐Oil Emulsions Encapsulating Various Additives. (2019)
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Skin for All","description":"Anti-acne solutions","content":"\n We have been facing some trying times these past few years – a global pandemic, war, political divide, and climate change. It is no wonder many of us feel so stressed out, on top of our daily worries around work, school, or personal relationships. We know stress isn’t healthy for the mind, body, and soul. But, it is particularly damaging to the skin because “in times of stress, your stress hormones rise and trigger your oil glands to produce more oil, which then triggers acne flares.”*
\n\n According to SPATE, the acne condition ranks #2 within the face concerns category of skincare, with the top subcategory of stress acne showing the highest year-over-year growth. We may not be able to resolve such global issues at Gattefossé, but we can surely provide you with self-care rituals to help you keep calm and Gatt’ your clear skin on!
\n\n
In overwhelming times, there truly is a need for cocooning and rejuvenating moments, which is why Gattefossé has developed a beauty routine comprised of 6 sensational creations that reinforce the pleasures of self-care while facing daily uncertainties. This light and fresh skincare kit guarantees an instant healthy glow and gives you a boost from morning to night!
\n\n
This vibrant yellow, lemon-curd-looking texture is actually a fruit acid face mask! Stable at low pH, Emulium® Dolcea MB creates its gourmand and thick texture while Glypure 70 and Lemon Secrets™ give a renewed and luminous complexion. Simply apply on dry skin, leave on for 10 min, and then rinse.
\n\n
No more shiny skin with this soft, formidable cream that mattifies the skin without drying it out. This creamy texture penetrates quickly and leaves a comfortable and matte film. Cytobiol™ Iris A² helps to fight against shine and reduce imperfections while Plurol® Stearique MB provides a dry, powdery after-feel.
\n\n
Other body areas such as the décolleté, back, and shoulders can also suffer from imperfections. This ultra-fluid bi-gel, made possible with Emulfree® CBG MB, has been specifically designed to purify these areas without leaving a sticky or greasy film, so it’s easy to get dressed after applying.
\n\n
Pimples are a thing of the past thanks to this natural transparent gel! Cytobiol™ Iris A² and Original Extract™ Lemon Bio help purify the skin and minimize breakouts. Plus, its texture is well-adapted for a pump or roll-on applicator for an ultra-targeted application.
\n\n
This fluid texture is ideal for fighting imperfections! It spreads easily, penetrates quickly, and leaves a very soft, thin protective film, as acne-prone skin also needs protection. Emulium® Dolcea MB, which has demonstrated its moisturizing properties, and high quantities of propanediol, guarantee hydration. Plus, the skin is purified and clearer thanks to Cytobiol™ Iris A² and Original Extract™ Lemon Bio.
\n\n
Wake up every morning with perfect skin, thanks to this multi-functional night cream! Formulated with Emulium® Mellifera MB, this texture penetrates quickly and leaves a fine, comforting protective film on the skin. Cytobiol™ Iris A² and Gatuline® Renew form an active combo that leaves the skin clear, matte, smoothed, and hydrated.
\n\n
Click here for more information or samples on the featured ingredients and formulas.
\n\n
\n
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As consumer interest in natural cosmetics continues to grow, the importance of natural actives as a key part of cosmetic formulations increases as well. Today’s consumer expects powerful efficacy from natural products. The challenge therefore becomes to find extraction methods that are both natural and effective in extracting the key active molecules from plants. NaDES is a new solution, adopted by Gattefossé, to create new, natural, and highly functional active ingredients.
\nWhen extracting active metabolites from plants, some molecules are more challenging than others. Despite perfect solubility in plant tissues, many of these molecules are poorly soluble in water, lipids, and even the most efficient known solvents. Additionally, traditional solvents such as butylene glycol are no longer acceptable to many consumers.
\nToday, there is an important need for green and bio-based solvents that improve sustainability and reduce the impact on the environment.
\n\n
\n
Recently, a new category of solvents has been discovered that is directly inspired by the way in which metabolites are solubilized inside the plant – through eutectic combinations of simple chemicals such as sugars, nitrogen compounds, and organic acids.
\nWorking with researchers from Leiden University, Gattefossé has developed and patented several natural eutectic solvents suitable for use in cosmetics, using all-natural components such as fructose, glycerin, and water. This exciting new class of solvents is natural, safe, and allows us to extract exciting new activity from plants.
\n\n
\n
“A eutectic mixture is defined as a mixture of two or more components which usually do not interact to form a new chemical compound but which, at certain ratios, inhibit the crystallization process of one another resulting in a system having a lower melting point than either of the components.”1
\nA NaDES can be defined as a eutectic mixture formed by a combination of natural molecules with specific molar ratio. At the eutectic ratio, the mixture is a homogenous liquid characterized by a supramolecular structure.
\n\n
\n
Our newest active, Gatuline® Link n Lift takes advantage of NaDES technology to bring improvement to the eye contour – visibly reducing difficult to erase under-eye and tear-trough wrinkles.
\nAs an example, the chart below shows the efficacy results of both traditional and NaDES solvents on Type IV collagen. You can clearly see that, in this case, combining a NaDES solvent with white chestnut flowers yielded the best results.
\n\n
\n
Gattefossé has obtained rights to develop and commercialize cosmetic active ingredients obtained using the highly innovative NaDES technology.
\nNatural, non-toxic and efficient at low temperatures, the NaDES technology is perfectly aligned with the Gattefossé strategy to provide high-performance sustainable ingredients with positive environmental impact.
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Fermement convaincus du pouvoir du travail collaboratif, René-Maurice Gattefossé, Henri-Marcel Gattefossé et Émile Mahler ont tous trois nourri de solides relations avec leurs collaborateurs et leurs partenaires professionnels et universitaires. Aujourd’hui l’entreprise s’emploie à perpétuer cet héritage et est fière de sa riche culture d’entreprise, influencée par la personnalité de ses fondateurs.
\nGattefossé est une entreprise à taille humaine, aussi mesurons-nous la valeur de l’investissement de chacun pour la réussite du groupe dans son ensemble. La croissance de notre entreprise repose sur les efforts coordonnés et quotidiens de l’ensemble de nos collaborateurs dans le monde, qui partagent une vision commune pour le futur.
\n\n
Gattefossé investit pour permettre à ses collaborateurs de rester à l’avant-garde dans leurs domaines.
\n
\n
Notre siège social et nos 12 filiales réunissent des collaborateurs de nationalités, cultures et formations diverses. Chez Gattefossé, nous considérons cette diversité comme un atout précieux et sommes convaincus que pour grandir ensemble, nous devons apprendre les uns des autres. Des rassemblements réguliers permettent ainsi à nos collaborateurs d’échanger leurs idées, leur vision stratégique et leurs bonnes pratiques.
Conformément à la législation française, Gattefossé a calculé pour sa structure principale en France, Gattefossé SAS, son Index d’égalité Professionnelle : au 31/12/2020, le résultat est de 89/100 :
\n\n
\n
\n
\n
\n
\n
« Mes priorités sont clairement orientées vers la pérennisation du développement de Gattefossé, à travers l’expansion de notre présence à l’international, la poursuite de nos efforts R&D et la conclusion de nouvelles alliances stratégiques.
\nCes objectifs sont en étroite relation avec ma vision, que les préceptes suivants de la culture familiale de notre entreprise résument très bien :
\n\n
Jacques Moyrand et sa femme, Sophie Gattefossé-Moyrand, ont créé la Fondation Gattefossé en 2008 avec la volonté de rendre hommage aux fondateurs de l’entreprise et de servir l’intérêt général sur le long terme.
La Fondation a pour vocation de promouvoir l’utilisation scientifique et clinique des huiles essentielles comme approche thérapeutique complémentaire pour la santé, en milieu hospitalier principalement
\n\n\n
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\nThis introductory webinar is a chance to get to know Gattefossé. We’ll present the many products and services that Gattefossé can offer to indie brands, discuss our current actions towards CSR and sustainability, and then open the floor to you for questions.
\nIt’s your chance to ask us everything you’ve ever wondered about who we are, what we offer, and how we can help you!
\n\n\n
\n
October 10, 2019 | 11am – 1pm
\nJoin us for an exciting event featuring Gattefossé and consumer research agency Spate.
\nThis 2-hour session will focus on consumer perceptions of the beauty industry today.
\n More information coming soon!
Sign up to receive updates about this event.
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\nPersonal data is information that may allow, directly or indirectly, the identification of a natural person. This includes, for example, surnames, first names, email addresses, telephone numbers, user names, IP addresses, cookies, etc.
\nThis Personal Data Protection Policy applies to personal data collected by Gattefossé directly from users (the “Users”) of the website www.gattefosse.com (the “Website”).
\nIn its capacity as data controller, Gattefossé undertakes to collect, process and store the personal data of Users in complete confidentiality and in accordance with the provisions of this Policy.
\nBy accessing the Website, the User acknowledges having read and accepted, without reservation, the terms of this Personal Data Protection Policy.
\nGattefossé collects the personal data that Users agree to provide. Data is collected and processed for the following purposes:
\nThe User is hereby informed of the purpose of processing prior to any collection of personal data and has the opportunity to oppose it.
\nIn accordance with legal requirements, the personal data of Users collected on the Website will be stored by Gattefossé only for the time required to fulfil the intended purpose, namely:
\nThe personal data collected will be deleted:
\n\n
Should it prove necessary, personal data collected on the Website may be communicated to other Gattefossé Group entities worldwide. The latter must comply with the processing purposes defined for this data.
\nThis data may not be sent to third parties for commercial and/or promotional purposes without the User’s prior consent.
\nOn the other hand, this data may be sent to certain service providers/technical subcontractors of Gattefossé (hosting company or audience analysis service in particular) bound to the confidentiality and security of this data and exclusively for the purposes described in Article 2 above.
\nIn the event that the data is transferred to a country that is not a member of the European Union and is not subject to an Adequacy Decision, Gattefossé will take all necessary measures to ensure that the data is protected with an appropriate level of confidentiality and security.
\nGattefossé may be required to send the data to the competent administrative or judicial authorities, at their request.
\nGattefossé undertakes to set up all necessary technical and organisational measures to preserve the confidentiality and security of the personal data collected on the Website.
\nHowever, Gattefossé cannot be held liable for a security failure attributable to the User.
\nWhen browsing the Website, cookies may be placed on the User’s device (computer, tablet, smartphone). A cookie is a small computer file deposited on the User’s device through their internet browser that allows certain data to be stored in order to facilitate browsing on a website and enable certain functionalities.
\nThe User is informed of the use of cookies by a banner that appears when connecting to the Website. The User may choose to authorise or prohibit all or some of the cookies by clicking on the “Customise” button on the banner.
\nThe disabling of certain cookies may alter the operation of the Website. The User is informed of this when personalising cookies. In the event that the User decides to prohibit a cookie necessary for the optimal operation of the Website, Gattefossé cannot under any circumstances be held liable for the consequences relating to the altered or impaired running of the Website.
\nCookies can be deposited by Gattefossé partners (such as Google Analytics for example). These partners may also use the information contained in cookies.
\nThe User is entitled to withdraw their consent and/or their choice to personalise cookies at any time.
\nInformation on the User’s consent and choice of personalising cookies will be retained by Gattefossé for thirteen (13) months.
\nIn accordance with the provisions of Law no. 7817 of 6 January 1978 on Technology, Files and Civil Liberties (known as “Loi Informatique & Libertés”) and European Regulation 2016/679 of 27 April 2016 (General Data Protection Regulation), the User has the following rights with regard to their personal data:
\nThese rights may be exercised at any time by the User by sending an email to: dataprotection@gattefosse.com, provided that proof of identity is attached.
\nIn the event of an unsatisfactory response from Gattefossé in exercising the rights mentioned below, the User may lodge a complaint with the French National Commission for Data Protection and Liberties (“CNIL”).
\nThis Personal Data Protection Policy may be updated at any time by Gattefossé without any formality other than the online publication of a new amended version, the latter prevailing over any previous version.
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April, 6, 2022 – Gattefossé receives an Innovation Award for Solastemis™
April, 4, 2022 – Gattefossé unveils Solastemis™, the next step towards photoprotection
February, 9, 2022 – Gattefossé strengthens its CSR approach and reaches two major milestones
January, 11, 2022 – Inspiration 2022, discover the new collection of formulations by Gattefossé
\n
October 28, 2021 – Gattefossé expands its offer with the launch of three new pharmaceutical excipients
July 12, 2021 – Gattefossé strengthens its strategy of developing responsible ingredients with 3 products labeled ERI 360°
June 8, 2021 – Ségolène Moyrand-Gros appointed President of the Gattefossé Group
April 1, 2021 – With EleVastinTM, Gattefossé fights gravity-induced skin sagging
March 15, 2021 – Gattefossé and BioMeca jointly developed a model of 3D dermal microtissue to study elastic properties in vitro
January 9, 2021 – A new 2021 edition for Gattefossé’s tool INSPIRATION
\n
December 18, 2020 – Gattefossé continues its international development and builds a production site in Texas
November 20, 2020 – Gattefossé launches its corporate website in Chinese
October 15, 2020 – Gattefossé releases new susbtantiation data on the resolution of inflammation
October 6, 2020 – Gattefossé presents Emulium® Dolcea MB, its latest natural O/W emulsifier
\n\nApril 9, 2020 – COVID-19: Gattefossé takes measures and continues to be operational
February 12, 2020 – Gattefossé comes into the microbiome discussion with a new study on its O/W emulsifier Emulium® Mellifera MB
January 9, 2020 – COSMET’AGORA 2020, a new edition for Gattefossé’s tool INSPIRATION
\n
October 31st, 2019 – Gattefossé reveals new clinical data for its natural origin active Gatuline® In-Tense MB
October 28th, 2019 – Gattefossé announces the release of Addiactive magazine in English
April 15th, 2019 – GOLD rating for Gattefossé on EcoVadis
April 3rd, 2019 – Gattefossé receives the Gold Innovation award for Emulium® Illustro
March 9th, 2019 – Definicire™ receives PCHi Fountain Awards 2019 in China
February 19th, 2019 – Gattefossé launches its new W/O emulsifier at in-cosmetics global
\n
December 17th, 2018 – COSMET’AGORA 2019, a new edition for Gattefossé’s tool INSPIRATION
October 23, 2018 – Gattefossé North America announces the recipient of the 2018 Award for Excellence
September 19th, 2018 – Gattefossé launches its first hair care
\n ingredient at in-cosmetics Latin America
July 10th 2018 – Gattefossé renews its ISO 9001 certification and achieves the 2015 version
June 5th 2018 – Official launch of ERI 360° Label
\n
April 10th 2018 – Meet the #ConnectedGenerations at in-cosmetics global 2018
\n
March 29th 2018 – EnergiNius™: Gattefossé new launch at in-cosmetics Amsterdam 2018
\n
February 20th 2018 – Gattefossé Asia Pacific achieves ISO9001: 2015 certification
\n
January 25th 2018 – Gattefossé launches INSPIRATION tool
\n
November 10th 2017 – Gattefossé North America announces the recipient of the 2017 Award for Excellence
\n
November 6th 2017 – SIO-ADM, Gattefossé partner to bring USP/NF grade highly refined oils to North America
\n
October 18th 2017 – GATTEFOSSÉ and CYTOO join forces to investigate the biological effects of screen-emitted light on skin
\n
September 20th 2017 – The Gattefossé foundation supports two Health establishments
\n
July 28th 2017- Gattefossé Canada and Connect Chemicals announce distribution agreement
\n
April 26th 2017- Inauguration of our North America Technical Center of Excellence
Contact us to receive the Press Dossier
\n\n\n\n
\n
March 29th 2017 – Show true emotions at in-cosmetics London: two ingredients targeting the eye and lip contours
\n
March 21th 2017 – Gattefossé Foundation promotes the training of healthcare personnel in the use of Madagascan essential oils in Madagascar
\n
March 6th 2017 – Gattefossé certified RSPO Mass Balance
\n
February 8th 2017 – New launch: Gatuline® Link n Lift – Redesign the eye contour
\n","useful_links":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/15502"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=15502"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/15502/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=15502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=15502"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=15502"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"pharmacie":{"id":12,"date":"2016-10-12T10:10:33","date_gmt":"2016-10-12T10:10:33","guid":{"rendered":"http://127.0.0.1/gattefosse/?page_id=12"},"modified":"2016-10-24T07:00:31","modified_gmt":"2016-10-24T07:00:31","slug":"pharmacie","status":"publish","type":"page","link":"https://www.gattefosse.com/content/pharmacie/","title":{"rendered":"Pharmacie"},"content":{"rendered":"
Amélioration solubilité/biodisponibilité, contrôle de libération, lubrification, masquage du goût.
\r\n\r\nEmulsionnants, solubilisants et agents de texture pour les émulsions, gels et lotions.
\r\n\r\nGlycérides hémi-synthétiques pour suppositoires et ovules avec actifs solides ou liquides.
\r\n\r\nLes dernières publications scientifiques des équipes Gattefossé
\r\n\r\nRetrouvez toutes les news Gattefossé
\r\n\r\nNos applications Orale Amélioration solubilité/biodisponibilité, contrôle de libération, lubrification, masquage du goût. Topique Emulsionnants, solubilisants et agents de texture pour les émulsions, gels et lotions. Rectale et vaginale Glycérides hémi-synthétiques pour suppositoires et ovules avec actifs solides ou liquides. Dans la presse Les dernières publications scientifiques des équipes Gattefossé Actualités Retrouvez toutes les news Gattefossé
\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[8],"tags":[],"acf":{"component":"PageContent","oneLoad":true},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/12"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/1"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=12"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/12/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=12"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=12"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=12"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"csr-action-plan-2":{"id":22816,"date":"2021-01-22T17:18:03","date_gmt":"2021-01-22T15:18:03","guid":{"rendered":"https://www.gattefosse.com/?page_id=22816"},"modified":"2022-02-09T13:13:54","modified_gmt":"2022-02-09T11:13:54","slug":"csr-action-plan-2","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-content/csr-action-plan-2/","title":{"rendered":"CSR action plan"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":19,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Discover our concrete, socially responsible commitments towards the environment and our people."},"categories":[48],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCorporate","title":"Our CSR roadmap","content":"\n
\n
Improving quality of life at work, personal development and safety of each employee while deploying strong and inclusive social values
\n\n
\n
\n
\n
“Over the past few years, our CSR approach has been developed and structured so that it is now at the heart of our development strategy. We consider CSR as a growth lever, a source of opportunity and innovation. Through Gatt’Up & Act, we would like to engage all our stakeholders to act in the service of the common good and general interest. I believe in the strength of the collective and that is how we will make a difference.” Ségolène MOYRAND-GROS, President of the Gattefossé Group
\n\n
\n
\n
Awarded Platinum by EcoVadis
\n
\n
Since 2017, our CSR approach is assessed by the world’s largest and most trusted provider of business sustainability ratings, EcoVadis. In 2021 we obtained the highest level of recognition “Platinum” with a score of 74/100, ranking Gattefossé in the TOP 1% of EcoVadis evaluations!
\nTo know more about the detailed results of this 2021 assessment, do not hesitate to request access to the following account in the EcoVadis website: Gattefossé SAS (Saint-Priest site).
\n\n
\n
\n
\n
After two years of work, Gattefossé obtains in October 2021 the ISO 14001:2015 certification for its main production site in Saint-Priest (France). A certificate validated from the first audit by the certification body SGS.
\n\n
\n
\n","useful_links":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22816"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/19"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=22816"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22816/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=22816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=22816"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=22816"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"sustainable-cosmetics-rspo":{"id":3930,"date":"2017-05-04T10:22:17","date_gmt":"2017-05-04T10:22:17","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3930"},"modified":"2017-05-31T14:14:33","modified_gmt":"2017-05-31T14:14:33","slug":"sustainable-cosmetics-rspo","status":"publish","type":"page","link":"https://www.gattefosse.com/espace-vip/personal-care-special-content/sustainable-cosmetics-rspo/","title":{"rendered":"Sustainable Cosmetics & RSPO"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[35],"tags":[],"acf":{"component":"PageSpecialContentPersonalCare","title":"Sustainable Cosmetics & RSPO","introduction":"Use of palm oil has deeply affected the biodiversity of Southeast Asia – contributing to deforestation and animal endangerment. To counter such damaging effects on the environment, a Roundtable on Sustainable Palm Oil (RSPO) was established in 2004. RSPO certification of palm oil is the promise that plantations involved offer a true guarantee of traceability along with improved working conditions.
\n
\n"},{"wysiwyg":"
\n
Palm oil dominates the worldwide oil market. It is used in food, energy, industrial uses, and of course, personal care. Yet its impact on deforestation and biodiversity have rightfully raised concerns – primary forest in Indonesia, the main producer of palm oil, is rapidly being eroded.
The rapid and unplanned culture of oil palm has deeply affected the biodiversity of Southeast Asia. As demand for palm oil has grown, deforestation and endangerment of local animal species has become a growing problem.
\n\n
\n"},{"wysiwyg":"
\n
To combat these environmental concerns, the Roundtable for Sustainable Palm Oil (RSPO) was created in 2004 with a goal of making sustainable cultivation of palm oil, respectful of people and the environment, the norm instead of the exception. RSPO certified sustainable palm oil has been produced to stringent environmental and social criteria.
\n\n\n
1 – Book & Claim – Certified palm producers register output with GreenPalm and are granted certificates for each ton of sustainable palm oil produced. Manufacturers bid for those certificates, thereby supporting the production of sustainable palm oil.
\n2 – Mass Balance (MB) – Allows for a mixture of sustainable and conventional palm oil. Overall volumes of each are carefully monitored
\n3 – Segregated SG – Allows for certified palm oil to come from a number of producers, but guarantees that the entire quantity of palm oil is sustainably produced.
\n4 – Identity Preserved – Requires that the supply be directly traceable. All steps in the supply chain are documented, creating a paper trail that can be followed back all the way from end-users to one specific palm grower.
\nLearn more about the pillars of RSPO and levels of certification here or at www.rspo.org.
\n"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/pages/3930"}],"collection":[{"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/comments?post=3930"}],"version-history":[{"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/pages/3930/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/media?parent=3930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/categories?post=3930"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/espace-vip/wp-json/wp/v2/tags?post=3930"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"lipid-based-formulations":{"id":26578,"date":"2022-03-16T12:19:30","date_gmt":"2022-03-16T10:19:30","guid":{"rendered":"https://www.gattefosse.com/?page_id=26578"},"modified":"2022-05-24T14:45:59","modified_gmt":"2022-05-24T12:45:59","slug":"lipid-based-formulations","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-special-content/lipid-based-formulations/","title":{"rendered":"Publications on lipid-based formulations"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":37,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on lipid-based formulations | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on lipid-based formulations."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on lipid-based formulations","introduction":"List of Gattefossé publications on lipid-based formulations.","":false,"content":[{"wysiwyg":"Jasmine Musakhanian, Jean-David Rodier and Masumi Dave
\nGattefossé
\nKetkee Deshmukh, Agnivesh Shrivastava, Sunil Bambarkar
\nPharma Times – Vol. 53 – No. 12, December 2021
\n\n\n"},{"wysiwyg":"
AGNIVESH SHRIVASTAVA , KETKEE DESHMUKH, RENUKA TIWARI, SUNIL BAMBARKAR, NABIL FARAH,
\n KAVITA SINGH
AAPS 2021
\nIn this study, Gelucire® 44/14 in type IV lipid-based formulation has been evaluated to increase the solubility and in vivo performance of ticagrelor.
\n\n"},{"wysiwyg":"American Pharmaceutical Review, February 2021
\nCamille Dumont, Cécile Morin
\n\nIntroduction
\nChapter I : Lipids, reliable partners to enhance oral bioavailability of poorly water-soluble drugs
\nChapter II : Lipids to enhance the intestinal permeability of poorly permeable drugs
\n
Chapter III : Targeting lymphatic absorption with appropriate lipid excipients selection
\nChapter IV : Mitigating food effect with lipid-based formulations
\nChapter V : Gattefossé range of functional excipients
\n for oral bioavailability enhancement
\n
Inayet Ellis
\nTablets & Capsules, April 2020
\n\n"},{"wysiwyg":"Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin
\nEuropean Journal of Pharmaceutical Sciences, Volume 137, 2019, 104967,
\n ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967.
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
\n[Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies]
\nE Levacher, C Buffangeix, MJ Celadon, I Decorte, P Gestin, J Hecq, F Jego, B Paillard, A Plantefeve, X Thomas
\nThe SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
\nInterestingly this article is both in French and English languages.
\n\nI Introduction
\nII Prerequisites
\n1 Initial identification and characterization of the active ingredient
\n 1.1 Physico-chemical characteristics
\n 1.2 Impact of physicochemical characteristics on absorption
\n 1.3 Passive diffusion prediction tools
\n 1.4 In silico prediction
\n 2 Biopharmaceutical classifications
III Formulation strategies
\n1 prerequisites
\n 2 techniques for increasing the dissolution rate
\n 3 Solubility enhancement technologies
\n 4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
\n1 Physicochemical control methods for the manufacturing intermediates and finished products
\n 2 Assessing an dpredicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
\nVI Conclusion: decision tree
\nPharma Times September 2019 – Special issue
\n\nLipid excipients in pharmaceutical technologies
\n Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
\n Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
\n Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
\n Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
\n Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
\n Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
\n Divya JAIN, Namita DESAI
Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Sunil BAMBARKAR, Nabil FARAH, Kavita SINGH
\nIn this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance
\nPoster CRS 2019
\n\n"},{"wysiwyg":"Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd
\nIn this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
\nA review of the techniques used to characterize the colloidal structures is also carried out.
\n\n"},{"wysiwyg":"Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
\n\n"},{"wysiwyg":"September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
\n\n"},{"wysiwyg":"Vincent Jannin, Stéphanie Chevrier, Matthieu Michenaud, Camille Dumont, Silvia Belotti, Yann Chavant, Fédéric Demarne.
\nThis acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
\n\n"},{"wysiwyg":"Vincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne
\nAAPS 2014
\n\n"}],"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/26578"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/37"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=26578"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/26578/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=26578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=26578"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=26578"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"granulation":{"id":2889,"date":"2017-04-25T08:31:30","date_gmt":"2017-04-25T08:31:30","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2889"},"modified":"2021-02-11T17:45:11","modified_gmt":"2021-02-11T15:45:11","slug":"granulation","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/granulation/","title":{"rendered":"Granulation"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Excipients for granulation | Gattefossé","_yoast_wpseo_metadesc":"Discover our range of modified release agents and wetting agents for wet granulation and melt granulation."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Granulation","content":"When powder properties are unsuitable for direct compression, a granulation step is required to improve compactibility, flow, and content uniformity.
\nLipid excipients are commonly used in two granulation techniques to modify drug dissolution, either as sustained-release or wetting agents:
\nAdvantages of lipid excipients in wet granulation:
\nAdvantages of lipid excipients in melt granulation:
\nRange of functional excipients for granulation:
\nA Gattefossé in-house study of continuous granulation via extrusion has demonstrated that
\nTwo cases studies are available:
\nWatch the video on continuous granulation with Precirol® ATO 5.
\n
\n
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science of high quality lipid excipient designing | Gattefossé","_yoast_wpseo_metadesc":"An in depth knowledge of oleochemistry enable us design high quality lipid excipients for the pharmaceutical industries."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Oleochemistry","introduction":"Gattefossé has designed and manufactured functional lipid excipients since 1950, developing strong capabilities in raw material qualification, synthesis reactions, process analytical technology, and quality control analysis.","":false,"content":[{"wysiwyg":"Our lipid excipients are manufactured using vegetable oils—including corn oil, apricot kernel oil, a wide array of plant-derived fatty acids—and alcohols—such as fatty alcohols, polyethylene glycol (PEG), propylene glycol (PG), and polyglycerol.
Raw materials are subject to strict quality control before use to ensure they meet pharmacopeia standards and often stricter company specifications.
\n"},{"wysiwyg":"Three reactions are commonly utilized in the manufacture of our excipients:
\nDepending on the raw materials used, these reactions enable the manufacture of solid, semisolid, or liquid excipients. The fatty-acid chain length and composition in terms of fatty alcohols and mono-, tri-, and diglycerides impact end-product physicochemical—hence functional—properties. Our oleochemists are thus able to develop pharmaceutical, nutraceutical, and cosmetic ingredients having targeted properties through the selection of raw materials and the design of synthesis reactions.
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Their input helps fine-tune processes to control impurity levels that can impact excipient performance and stability.
\nThey are also working on processes that enable the reduction of waste materials, water consumption, and the use of catalysts.
\n"},{"wysiwyg":"Many of our lipid excipients are complex multicomponent products. Our oleochemists develop and validate specialized analytical methods which serve four main purposes:
\nGattefossé has and continues to be a source of new validated analytical methods for lipid excipients, many of which have been incorporated into the European Pharmacopoeia.
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\nRange of excipients for high shear coating
\nHow to obtain sustained release tablets of metformin hydrochloride by direct compression ?
\nThe aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\nKeywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load
\n
How to reduce drug release variability in HPMC-based sustained-release tablets ?
\nThe aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
\nKeywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO
\n\n"},{"wysiwyg":"
How to formulate a simple emulgel with a high level of Transcutol® P
In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
\nKeywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH
\n"}],"box_links":[{"link":"https://www.gattefosse.com/personal-care-actives/pharmaceuticals-product-finder/product-finder-pharmaceutical/","title":"Access our product finder","external_link":false,"image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/tableau_noir_624x221px.jpg"},{"link":"https://www.gattefosse.com/personal-care-actives/pharmaceuticals-formulation-technologies/formulation-technologies/","title":"Understand how to use our excipients","external_link":false,"image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/technologies_196x143px.jpg"}],"useful_links":[],"":false,"introduction":"Case studies are available after log-in!","vignets_articles":[{"image":{"id":19244,"alt":"","title":"NS POCC497","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","width":401,"height":257,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497-300x192.jpg","medium-width":300,"medium-height":192,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","medium_large-width":401,"medium_large-height":257,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","large-width":401,"large-height":257,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","post-thumbnail-width":401,"post-thumbnail-height":257,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","twentyfourteen-full-width-width":401,"twentyfourteen-full-width-height":257}},"title":"How to select the best permeation enhancer for benzoylaconitine transdermal patch?","text":"Due to the high molecular weight of Benzoyl Aconitine (603.7), formulating a transdermal patch is a challenge. Among all the tested permeation enhancers, Plurol® Oleique CC 497 showed the best results.
\nKeywords: transdermal patch, Benzoyl Aconitine, Plurol® Oleique CC 497, FT-IR analysis
\n
The aim of this study was to prepare tablets by wet granulation using Gelucire® 44/14 to improve the dissolution of fenofibrate.
\nKeywords: tablet, wet granulation, fenofibrate, Gelucire® 44/14
\n","link":"https://www.gattefosse.com:443/back/files/CS 2020 04 Fenofibrate tablets with Gelucire 44_14.pdf"},{"image":{"id":17367,"alt":"","title":"Woman with Patch on Arm","caption":"Woman with Patch on Arm","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","width":106,"height":150,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674-106x150.jpg","thumbnail-width":106,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium-width":106,"medium-height":150,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium_large-width":106,"medium_large-height":150,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","large-width":106,"large-height":150,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","post-thumbnail-width":106,"post-thumbnail-height":150,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","twentyfourteen-full-width-width":106,"twentyfourteen-full-width-height":150}},"title":"How to formulate a daphnetin transdermal patch with enhanced permeation? ","text":"The aim of the study was to develop an optimized drug-in-adhesive patch with 1% daphnetin with good in vitro drug release and skin permeation. Backing films, permeation enhancers and permeation enhancer content were investigated through in vitro experiments.
\nKeywords: transdermal patch, daphnetin, Transcutol® P
\n
The feasibility of preparing solid SEDDS using solid (Gelucire® 48/16) and semi-solid (Gelucire® 44/14) lipid excipients with a 3D printer is assessed using two model drugs, i.e. cinnarizine and fenofibrate.
\nKeywords: 3D printing, Gelucire® 44/14, Gelucire® 48/16, fenofibrate, cinnarizine
\n","link":"https://www.gattefosse.com/back/files/CS_2019_04_Are%20lipid%20excipients%20suitable%20for%203D%20printing.pdf"},{"image":{"id":12307,"alt":"Gattefosse_oblong tablet","title":"Gattefosse_oblong tablet","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-e1550647845517.jpg","width":365,"height":244,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-300x200.jpg","medium-width":300,"medium-height":200,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-768x513.jpg","medium_large-width":474,"medium_large-height":317,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-e1550647845517.jpg","large-width":365,"large-height":244,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-967x576.jpg","twentyfourteen-full-width-width":967,"twentyfourteen-full-width-height":576}},"title":"How to obtain sustained release tablets of metformin hydrochloride by direct compression ?","text":"The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\nKeywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load
\n
The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
\nKeywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO
\n","link":"https://www.gattefosse.com/back/files/How%20to%20reduce%20drug%20release%20variability%20in%20HPMC%20based%20sustained%20release%20tablets%20.pdf"},{"image":{"id":12179,"alt":"","title":"Gattefosse_27776","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776.jpg","width":2598,"height":1951,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-300x225.jpg","medium-width":300,"medium-height":225,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-768x577.jpg","medium_large-width":474,"medium_large-height":356,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1024x769.jpg","large-width":474,"large-height":356,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"How to formulate a simple emulgel with a high level of Transcutol® P","text":"In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
\nKeywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH
\n","link":"https://www.gattefosse.com:443/back/files/CS_201901_How to formulate an emulgel with high level of Transcutol P.pdf"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/pages/12124"}],"collection":[{"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/comments?post=12124"}],"version-history":[{"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/pages/12124/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/media?parent=12124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/categories?post=12124"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/personal-care-actives/wp-json/wp/v2/tags?post=12124"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gatuline-in-tense-mb":{"id":1640,"date":"2017-04-26T10:50:11","date_gmt":"2017-04-26T10:50:11","guid":{"rendered":"/?page_id=1640"},"modified":"2021-05-06T09:18:23","modified_gmt":"2021-05-06T07:18:23","slug":"gatuline-in-tense-mb","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-actives/gatuline-in-tense-mb/","title":{"rendered":"Gatuline® In-Tense MB"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gatuline® In-Tense | Firming anti-aging active | Gattefossé","_yoast_wpseo_metadesc":"Gatuline® In-Tense targets cell communication to reorganize and retighten the dermal architecture for a natural lifting and smoothing effect."},"categories":[6],"tags":[],"acf":{"component":"PageCosmeticProduct","product_codes":[{"code":"5932"}],"bandeau_image":{"id":17411,"alt":"","title":"Beautiful young woman with skipping rope","caption":"Beautiful young woman with skipping rope. 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Face and body contours lose their definition, décolleté and neck areas become wrinkled.
\nGatuline® In-Tense MB is an active ingredient of natural origin that acts deeply in the skin, in the extra-cellular matrix. By stimulating fibroblasts’ activity, it provides support to the collagen fiber network and restores firmness and smoothness of the face and the body.
\n","use_level":"1-2%","naturalite":"","inci":"Caprylic/Capric Triglyceride (and) Acmella Oleracea Extract","origin":"Gatuline® In-Tense MB is a concentrated oily extract taken from the flower of the Acmella Oleracea plant also called Paracress or “Brède mafane”, a traditional spicy condiment. Acmella Oleracea is renowned for its high content in alkylamides, markers of the plant activity.
\nSpecial attention is given to a selective harvest of the flowers (upper buds only), so that the plant can be used by local population for other applications, especially for cooking.
\nEfficacy validated through complete substantiation studies:
\nTargeted solution for firming body and facial care
\n","img":false,"video":"https://www.youtube.com/embed/a2HMW2DljFA"}],"claims":"Traditionally, youth has been the driving message behind fashion and beauty advertising. The overwhelming message in advertising and media has been that youth is the holy grail. However, today the message is changing, to better reflect the reality of aging and beauty of life.
\n\n
\n
According to recent articles, the way you perceive aging can actually influence how you age. “Positive and negative attitudes can affect your health behaviorally, psychologically, and even biologically. Being ‘pro-aging’, or satisfied with your own aging, can make you adopt healthier behaviors, feel in control of how you age, and even heighten your immune system.”1
\n\n
\n
We are beginning to see this shift towards pro-aging make its way into beauty and cosmetics. Baby boomers, as they age, are realizing that aging can’t be fought forever and are instead embracing the changes that come with time. And cosmetics companies are moving with the mindset of their customers.
\n\n
\n
Pro-aging doesn’t mean a rejection of cosmetics, but rather a more targeted selection towards products designed to enhance the appearance at any age, instead of hiding and fighting every symptom of aging. The philosophy behind pro-aging is to remove all “anti” claims and replace them with more positive imagery. “Pro-age products are more about nourishing and moisturizing the skin, enhancing features rather than trying to fill them in or mask them.”2
\n\n
\n
Gattefossé offers ingredients that meet the demands of the pro-aging trend.
\n\n
Download the formula sheets in the “Related documents” box in the right column.
\n\n
\n","box_links":[],"useful_links":[{"text_link":"5 powerful benefits of 'pro-aging' thinking (CNN.com)","link":false,"external_link":"http://www.cnn.com/2015/01/02/health/age-self-fulfilling-prophecy/"},{"text_link":"Anti-Aging Products Dominate the Cosmetics Industry, but Will the “Pro Age Revolution” Challenge That? (Glammonitor.com)","link":false,"external_link":"http://www.glammonitor.com/2015/anti-aging-products-dominate-the-cosmetics-industry-but-will-the-pro-age-revolution-challenge-that-2920/"}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":13960,"alt":"","title":"pro-aging","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/pro-aging-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"description":"","view_all":"personal-care/trends-education-inspiration/","filter_categories":["inspiration-trends"]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2518"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=2518"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2518/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=2518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=2518"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=2518"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"show-true-emotions":{"id":2512,"date":"2017-04-21T10:24:28","date_gmt":"2017-04-21T10:24:28","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2512"},"modified":"2019-05-03T11:10:26","modified_gmt":"2019-05-03T09:10:26","slug":"show-true-emotions","status":"publish","type":"page","link":"https://www.gattefosse.com/products/personal-care-trend/show-true-emotions/","title":{"rendered":"Show True Emotions"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"Show True Emotions","content":"
\n
Smiling, squinting, pursing the lips: expression lines are the results of thousands of daily involuntary micro-contractions of the facial muscles. These fine lines start being visible around the age of 30 and turn into deep wrinkles over the years. As they become more visible, they can lead to the expression of inappropriate emotions.
\nCrow’s feet, under-eye wrinkles, tear trough( also called valley of tears) and bitterness folds (located at the corner of the mouth) can thus give the impression of sadness, sorrow and grief.
\n\n
\n
Gatuline® Link n Lift, is a new active ingredient that has been developed especially for the eye contour area. Based on horse chestnut flowers and obtained using NaDES technology, Gatuline® Link n Lift restores fibroblast dynamism and acts on the dermal-epidermal junction to reconnect the epidermis to the dermis. As a result, wrinkles around the eyes are visibly reduced and positive expressions are restored for a younger and fresher look.
\nUsed at 2% in formulation, Gatuline® Link n Lift visibly acts on all eye contour wrinkles. The double blind clinical study versus placebo confirms the eye contour rejuvenation, with the first effects visible in just 2 weeks.
\n\n
\n
Targeting expression lines, Gatuline® Expression AF helps smooth the skin around the lips and redesigns the entire mouth contour. A clear reduction of the barcode wrinkles and bitterness folds has been assessed using instrumental techniques. The lip contour appears better defined, sharper and the natural curve of the Cupid’s bow is recovered, for a more sensual smile.
\n\n
\n
The Gattefossé application laboratories have worked on five emotions reinvented with innovative textures, to enrich and transform the daily beauty routine. From Korean-inspired to all-natural textures, the skin will enjoy the full intensity of using these 5 formulations featuring Gattefossé ingredients.
\nDownload the formula sheets in the “Related documents” box in the right column.
\nGATTEFOSSE SAS
\n36 chemin de Genas
\n CS 70070 69804 Saint-Priest Cedex
\n France
\n +33 (0)4 72 22 98 00
\n contact@gattefosse.com
Incorporated in France as a “Société par actions simplifiée” with a capital of 4,650,000 euros, registered with the Lyon Trade and Companies Register under No. 389 586 900,
\nPublishing Director: Ségolène Moyrand-Gros, Group Director – Corporate Development
\nHosted by:
\n\n GATTEFOSSE SAS
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\nPoster – AAPS 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster AAPS 2016
\n\n\n"},{"wysiwyg":"
November 2016
\nPharmaceutical foams are becoming more popular probably due to more topical medicines being switched to OTC and the need to innovate and differentiate ‘brands’ and an increasing awareness of the importance of formulating to deliver sensorial benefits and positive impact on patient experience and adherence. Gattefossé, as a leading provider of excipients for the pharmaceutical industry, manufactures solubilizers and texturizers for skin drug delivery. In this white paper we give formulation tips for propellant and propellant-free foams with guidelines on how to formulate and select excipients and case studies with model drugs.
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster Skin Forum, June 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André, D Hoste and D Marchaud
\nPoster PBP, April 2016
\n\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/4241"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=4241"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/4241/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=4241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=4241"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=4241"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"bi-gel":{"id":25071,"date":"2021-09-27T16:14:06","date_gmt":"2021-09-27T14:14:06","guid":{"rendered":"https://www.gattefosse.com/?page_id=25071"},"modified":"2021-10-08T11:15:37","modified_gmt":"2021-10-08T09:15:37","slug":"bi-gel","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/bi-gel/","title":{"rendered":"Bi-gel"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Bi-gel | Gattefossé","_yoast_wpseo_metadesc":"Bi-gels consist of an intimate mixture of an aqueous gel and an oily gel."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Bi-gel","content":"Bi-gels consist of an intimate mixture of an aqueous gel and an oily gel.
Due to their dual nature, bi-gels are associated with the following advantages:
\nGeleol™ Mono and diglyceride NF
\nOriginal Extracts™ are living waters designed especially for cosmetic formulations. Directly obtained from fruits or plants, they contain well-balanced amounts of trace elements, mineral salts, and essential oils. Extracted using targeted technologies, without solvents or contact with external water, they are pure and all-natural. They can partially or completely substitute the water of cosmetic formulations.
\n","use_level":"up to 100%","naturalite":"ECOCERT/COSMOS approved (natural)Preservative free. 100% natural: Apple, Bamboo, Grape, Grapefruit, Orange, Ginger, Rice, Kiwi, Lotus 100% organic: Cranberry Bio, Cherry Bio, Grape Bio, Orange Bio, Lemon Bio
\nObtained without maceration or addition of external water, these plant and fruit waters can partially or completely substitute the water of cosmetic formulations. Produced from 100% organic fruit, organic Original Extracts™ are the ideal ingredients for the development of certified organic cosmetics.
\n","img":{"id":3499,"alt":"Water splash","title":"Water splash","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/OE.jpg"},"video":""}],"claims":"\n
New : an International prize of 10 000€ recognizes the achievement of an aromatherapy / clinical team that uses essential oils in a health facility, as a complementary treatment. Candidates should demonstrate (using clinical evidence) direct benefits for the patient with regards to their treatment outcome and/or well-being. All countries are eligible except France.
\nThis application form should be completed and sent to fondation@fondation-gattefosse.org with all requested appendices (for large files, please use cloud storage services: WeTransfer, Dropbox…)
\nEnglish language is mandatory: the application form and supplied documentation will be accepted in English only and the applicant should be sufficiently fluent to be able to present his/her work in English.
\n→ Download your application form for the 2021 International prize
\nThis pdf document contains editable text zones. Be sure to use Acrobat reader to open it and respect the space available for answers.
\n"},{"wysiwyg":"\n
A French Prize of 10 000€ recognizes the achievement of an aromatherapy / clinical team that uses essential oils in a French hospital, as a complementary treatment. Candidates should demonstrate (using clinical evidence) direct benefits for the patient with regards to their treatment outcome and/or well-being.
\nThis application form should be completed and sent to fondation@fondation-gattefosse.org with all requested appendices (for large files, please use cloud storage services: WeTransfer, Dropbox…). This pdf document contains editable text zones. Be sure to use Acrobat reader to open it and respect the space available for answers.
\nDeadline: 28 february 2021
\n→ Download your application form for the 2021 French Prize
\n"},{"wysiwyg":"\n
Six French grants of 5 000€ support aromatherapy initiatives and projects in French hospitals in three categories: scientific aromatherapy training, setting up an aromatherapy approach or a clinical study.
\nThis application form should be completed and sent to fondation@fondation-gattefosse.org with all requested appendices (for large files, please use cloud storage services: WeTransfer, Dropbox…). This pdf document contains editable text zones. Be sure to use Acrobat reader to open it and respect the space available for answers.
\nDeadline: 28 february 2021
\n→Download your application form for the 2021 Grants
\nFinancial support, consisting of 500€ grants, is available for students carrying out their thesis in clinical aromatherapy in a French university. The subject of the thesis must include clinical research or an internship in a medical establishment.
\nThis application form should be completed and sent to fondation@fondation-gattefosse.org with all requested appendices (for large files, please use cloud storage services: WeTransfer, Dropbox…)
\n→Download your request form for thesis support
\n"},{"wysiwyg":"\n
A new special program for healthcare teams to help the initiatives of aromatherapist in french hospitals who, in this period of health crisis, set up olfactive sticks or diffusion of essential oils to reduce the stress of caregivers specifically.
\nPlease check the French page for more information.
\n"},{"wysiwyg":"\n\nThe skin around the eyes is thinner than on any other part of our bodies, which makes it the most sensitive to change. Short nights, stress, and fatigue all contribute to puffiness and dark circles, affecting 80% of all women and as much as 50% of all men. Undereye bags and dark circles are the result of several disorders, including weak blood and lymphatic capillaries, poor drainage of interstitial fluids, skin sagging, and a reduction in microcirculation.
\n","use_level":"5%","naturalite":"","inci":"Butylene Glycol (and) Water (and) Niacinamide (and)Cytobiol™ Lumin-Eye is an active blend based on the complementary benefits of three components: ash tree bark extract, vitamin B3 and organic silicon.
\nPreservative free.
\nThe high ash (Fraxinus excelsior) is a large tree commonly found in European forests. It draws its name from Latin fraxinus (“lightning”) because its height of up to 40 m attracts lightning.
\nIts bark contains esculin and fraxin, two heterosides known to actively decrease the permeability of blood capillaries. These compounds give Cytobiol™ Lumin-Eye veinotonic and vasculoprotective properties. Moreover, fraxin and esculin have antioxidant activity that helps protect the blood capillaries while simultaneously resisting the breakdown of hemoglobin to reduce coloration under the eyes.
\nCytobiol™ Lumin-Eye simultaneously targets each of the processes behind premature aging of the eye contour for a brighter, younger appearance.
\nIn vivo tests prove Cytobiol™ Lumin-Eye effectively reduces:
\nHard fat suppository base comprising polyoxylglyceride esters to enhance drug solubility and bioavailability.
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It consists of three main steps: powder blending, lubrication, and compression. Atomized lipid excipients are used as lubricants or modified-release agents in direct compression.
\n\nAdvantages of lipid excipients in direct compression:
\nRange of functional excipients for direct compression:
\n\n
Sticking issue
\nSticking during tableting is a relatively common problem. It is often attributable to tooling and machine setup. However, the formulation, active ingredient, and excipients can play an important role. We conducted an in-house study to evaluate the cause of punch adhesion or “sticking,” which occasionally occurs during the compression of powder formulations containing Compritol® 888 ATO. Our study concludes that sticking is primarily due to a combination of factors, including formulation with a “sticky” API and use of ingredients with reduced interparticle bonding capacity.
\nContact Gattefossé for the full study report.
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Their physicochemical properties have been optimized to provide excellent drug delivery for both solid and liquid active pharmaceutical ingredients (APIs), across the range of water solubility.
\n
\n
We offer a wide range of bases for suppositories and pessaries. Here you will find a selection of the most versatile grades. Our bases and formulation expertise enable you to:
\nThese multipurpose vehicles span a range of melting points and hydroxyl values and are suitable for a wide spectrum of APIs. They are ideal for straightforward formulations using manual, semi-automated, or fully automated equipment.
\nSuppocire® Grade | \nSuppocire® Main Characteristics | \n
Suppocire® AM | \nLow melting point | \n
Suppocire® NAI 25 A | \nLow melting point; long-chain glycerides enable production of hard suppository units | \n
Some APIs are more difficult to formulate due to properties such as hydrophilicity, sensitivity to oxidation, or high drug load. They require special bases like the following:
\nDrug Characteristics | \nSuppocire® Grade | \n
Liposoluble | \nSuppocire® CM | \n
Hydrophilic | \nSuppocire® NAS 50 | \n
Glycerin | \nSuppocire® AGP | \n
Sensitive to oxidation | \nSuppocire® NA 15 | \n
Ovucire™ Grade | \nOvucire™ Main Characteristics | \n
Ovucire™ 3460 | \nGood mechanical resistance and enhanced spreadability within the vaginal cavity | \n
Ovucire™ WL 3264 | \nWith additive to enhance API dispersion and wettability | \n
\n
Contact Gattefossé to obtain reference formulations with APIs such as acetaminophen, clotrimazole, diclofenac sodium, econazole nitrate, hydrocortisone acetate, ketoprofen, lidocaine hydrochloride, mesalamine, metronidazole, miconazole nitrate, nystatin, papaverine, phloroglucinol, piroxicam, probiotics, procaine, progesterone, and ruscogenin in association with trimebutine.
A nonionic oil-in-water emulsifier for topical formulations that provides high stability in topical fluid lotions and light emulsions over a wide pH range.
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\nNos formulateurs travaillent en étroite collaboration avec notre pôle recherche et développement pour analyser le comportement de nos ingrédients cosmétiques et nos excipients pharmaceutiques et mettre en évidence leurs bénéfices en formulation. Nous sommes ainsi en mesure de proposer à nos clients des solutions innovantes et efficaces, en adéquation avec les besoins des marchés cosmétique et pharmaceutique et les réglementations en vigueur à travers le monde.
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Touch and feel are important factors when buying beauty and personal care products. Consumers attach great importance to the texture and comfort of a formulation. Their enjoyment of a given texture encourages use and repurchase, creating a connection between product and consumer.
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\nEmulium® 22 MB gives consumers this subtle surprise that they are looking for.
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","date":"01.08.2022","content":"Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
E. Dauphin-Chanard ; A. Forest ; C. Deleglise ; D. Hoste ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
\n\n\n
\n
\n
\n
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Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
Masumi Dave ; Jasmine Musakhanian ; Jason LePree and Rollie Fuller
\nGattefossé USA – Paramus – USA
\n\n\n
\n
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Gelucire® 48/16: a safe wetting agent for tablet. A case study with fenofibrate
E. Dauphin-Chanard ; JM. Girard ; C. Deleglise ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
\n\n\n
\n
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\n
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\n Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers
Fiona McCartney ; Camille Dumont ; Philippe Caisse and David J. Brayden
\nUniversity College Dublin
\n\n\n
\n
\n
\n
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Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets
Agnivesh Shrivastava ; Renuka Tiwari ; Ketkee Deshmukh and Sunil Bambarkar
\nGattefossé India – Mumbai – India
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Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
E. Dauphin-Chanard ; A. Forest ; C. Deleglise ; D. Hoste ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
\n\n\n
\n
\n
\n
\n
\n
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
Masumi Dave ; Jasmine Musakhanian ; Jason LePree and Rollie Fuller
\nGattefossé USA – Paramus – USA
\n\n\n
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\n
\n
\n
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Gelucire® 48/16: a safe wetting agent for tablet. A case study with fenofibrate
E. Dauphin-Chanard ; JM. Girard ; C. Deleglise ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
\n\n\n
\n
\n
\n
\n
\n
\n
\n Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers
Fiona McCartney ; Camille Dumont ; Philippe Caisse and David J. Brayden
\nUniversity College Dublin
\n\n\n
\n
\n
\n
\n
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Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets
Agnivesh Shrivastava ; Renuka Tiwari ; Ketkee Deshmukh and Sunil Bambarkar
\nGattefossé India – Mumbai – India
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