Selecting efficient pharmaceutical binder for developing robust extended release matrices of Compritol ® 888ATO prepared using wet granulation technique
Part 1 Studying impact on granule & tablet properties
Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
Let’s now discover the Glittering Gummies (2745-3.04), a surprising travel-friendly format for a highlighter, made possible by Emulium® Kappa MB! Compact and easy to carry, this solid O/W emulsion is perfect for touch-ups on the go.
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It offers an ultra-bouncy effect and melting sensation thanks to Lipocire® A SG and creates a fresh and watery effect upon application. \n (97.4% natural origin)
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Craving uniqueness? The Holo Eye Liner (2758-1.11) has been designed to reveal the eccentricity living in you while reamining smudge-free and waterproof. Creamy and quick-drying, it melts seamlessly thanks to Lipocire® A SG to leave an intense purple, holographic line with long-wear properties! Emulium® Dolcea MB shows unfailing efficiency and robustness with this formula rich in pigments. \n (92% natural origin)
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Playground
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What if everyday life became a playground (again)? Gattefossé encourages more playful cosmetic application with our Cottage Cheese cream (2748-1.11) and its Squid Ink Topping (2748-2.04)! With Emulium® Dolcea MB, Acticire® MB, and EnergiNius® this creamy, yogurt-like texture delivers moisturizing and energizing benefits, perfect for daily application. Recommended once a week or once a month, mix it with 2 drops of the Squid Ink Topping, enriched with Original Extract® Ginger, to create your own detox mask! \n (99.5% natural origin)
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Experience the unexpected
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It’s time to discover new territories! Between the real and imaginary, appearances can be misleading… \n Like the Chayote-Kiwi Sorbet (2694-3.03), is it a beauty sorbet or a granita? With its light green color, you first see a food-like texture that you would love to eat. Upon initial application, you’ll feel a fresh, creamy yet powdery sensation, that leaves a dry, soft, non-tacky after-feel due to Emulium® Mellifera MB. This cushion cream brings a refreshing and intense moisturization, acts as a blur, and protects the skin from photoaging with Solastemis™. The skin appears radiant, even, and healthy. \n (99.4% natural origin)
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Alien Slime (2614-3.01) is another optical illusion! is it slime, or is it a cosmetic? Try it and you’ll be surprised by its comfortable, stringy, but non-sticky after-feel thanks to Emulium® Dolcea MB & Acticire® MB.
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Adapted for sensitive skin, it has a long playtime which is perfect for a soothing massage! It can also be used as a leave-on so that you can appreciate its nourishing properties. \n (98.2% natural origin)
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A solid co-emulsifier in topical formulations to improve stability of emulsions. A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS).
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Lauroyl polyoxyl-6 glycerides
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Lauroyl macrogol-6 glycerides
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8EPU9MJ01K
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HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS
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Polyoxylglycerides
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Co-emulsifier in topical formulations often associated with Tefose® 63. Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS). Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.
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A high-purity solvent and powerful solubilizer associated with skin penetration enhancement in topical dosage forms.
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Diethylene glycol monoethyl ether
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Diethylene glycol monoethyl ether
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A1A1I8X02B
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DIETHYLENE GLYCOL MONOETHYL ETHER
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Diethylene glycol monoethyl ether
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Consists of highly purified diethylene glycol monoethyl ether
Solvent and powerful solubilizer. Penetration enhancer for topical formulations. Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved topical medicines.
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A glyceride with a high melting point used as a modified release agent or lubricant in tablets. Can also be used in lipid coating technologies and as lipid carrier for nanoparticles.
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Glyceryl dibehenate
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Glycerol dibehenate
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R8WTH25YS2
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GLYCERYL DIBEHENATE
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Glyceryl Behenate
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A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
\n
Bryce W. Barber, Camille Dumont, Philippe Caisse, George P. Simon, Ben J. Boyd
A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics
\n
Vithani K, Goyanes A, Jannin V, Basit AW, Gaisford S, Boyd BJ
\n
Pharm Res. 2019 May 16;36(7):102. \n doi: 10.1007/s11095-019-2639-y.
\n
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
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As the skin ages, a progressive disorganization of the dermal structure occurs and is responsible for reduced firmness and tonicity. Face and body contours lose their definition, décolleté and neck areas become wrinkled.
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Gatuline® In-Tense MB is an active ingredient of natural origin that acts deeply in the skin, in the extra-cellular matrix. By stimulating fibroblasts’ activity, it provides support to the collagen fiber network and restores firmness and smoothness of the face and the body.
Gatuline® In-Tense MB is a concentrated oily extract taken from the flower of the Acmella Oleracea plant also called Paracress or “Brède mafane”, a traditional spicy condiment. Acmella Oleracea is renowned for its high content in alkylamides, markers of the plant activity.
\n
Special attention is given to a selective harvest of the flowers (upper buds only), so that the plant can be used by local population for other applications, especially for cooking.
Stimulates the biomechanical functions of the fibroblasts
\n
Reduces wrinkled appearance of the face and neck
\n
Smoothes the décolleté area
\n
Makes body skin firmer, more tonic
\n
\n","applications":"
\n
Facial care: day and night lines, anti-aging, anti-wrinkles, facial contour remodeling
\n
Body care: firming, body sculpting
\n
Make up: firming foundations, replumping lipsticks
\n
\n","actives":["wrinkles"],"actives_secondary":["preservative_free","alcohol_free","bg_free"],"textures":"","textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1640"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=1640"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1640/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=1640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=1640"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=1640"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"emulium-22-mb":{"id":1730,"date":"2017-04-23T14:38:01","date_gmt":"2017-04-23T14:38:01","guid":{"rendered":"/?page_id=1730"},"modified":"2019-05-03T15:42:44","modified_gmt":"2019-05-03T13:42:44","slug":"emulium-22-mb","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-textures/emulium-22-mb/","title":{"rendered":"Emulium® 22 MB"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Emulium® 22 | O/W sensory emulsifier | Gattefossé","_yoast_wpseo_metadesc":"Emulium® 22 MB is an O/W sensory emulsifier that is characterized by its low film residue, creating light, matte textures for elegant emulsions."},"categories":[14],"tags":[],"acf":{"component":"PageCosmeticProduct","product_codes":[{"code":"5432"}],"bandeau_image":{"id":13821,"alt":"","title":"emulium 22","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2.jpg","width":1144,"height":400,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-2-1038x400.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":400}},"image_product_finder":{"id":2342,"alt":"Thin woman wearing a long flowing and white dress","title":"Gattefossé Emulium® 22","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","width":244,"height":163,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","medium-width":244,"medium-height":163,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","medium_large-width":244,"medium_large-height":163,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","large-width":244,"large-height":163,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","post-thumbnail-width":244,"post-thumbnail-height":163,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium-22.jpg","twentyfourteen-full-width-width":244,"twentyfourteen-full-width-height":163}},"title":"Emulium® 22 MB","tagline":"Elegant paradox","description_product_finder":"","introduction":"
Touch and feel are important factors when buying beauty and personal care products. Consumers attach great importance to the texture and comfort of a formulation. Their enjoyment of a given texture encourages use and repurchase, creating a connection between product and consumer.
\n
Today’s consumer also wants to be surprised and charmed by skin care products. Textures that offer something unusual create a unique experience for the user.
\n
Emulium® 22 MB gives consumers this subtle surprise that they are looking for.
\n
An O/W emulsifier, Emulium® 22 MB creates fine, elegant emulsions with a transforming skin feel. While products formulated with Emulium® 22 MB look thick and rich in the jar, they are surprisingly light to the touch, with a long play time, light after-feel, and matte finish.
Emulium® 22 MB has a long behenic chain (C22) and yields nontacky, nongreasy emulsions that leave only a very light residual film—even when used with UV filters.
Emulium® 22 MB may be used for a range of viscosities, from lotion to cream.
\n
Sensory profile:
\n
\n
bright, creamy, rich appearance
\n
excellent pick-up
\n
evanescent feel (light and thin)
\n
easy spreading and rapid absorbency
\n
nongreasy, nontacky after-feel
\n
matte finish and little film residue
\n
\n","img":{"id":3693,"alt":"Closeup shot of hands applying moisturizer. Beauty woman holding a glass jar of skin cream. Shallow depth of field with focus on moisturizer.","title":"Closeup shot of hands applying moisturizer. Beauty woman holding a glass jar of skin cream. Shallow depth of field with focus on moisturizer.","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/emulium22.jpg"},"video":""},{"content":"
Properties:
\n
Ideal for sun care and make-up applications, Emulium® 22 MB:
\n
\n
works well with sunscreens, pigments, lotions, and supple creams
\n
yields fine emulsions and optimal dispersion
\n
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\n
Excellent stability
\n
Refined touch
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Fine emulsions
\n
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Skin care—all skin types, for day and night applications
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Nature is a constant inspiration for cosmetics ingredients, but plants are not the only sources of natural actives. Mineral Matters™ liquid stone extracts apply special technology to extract important minerals from precious stones and make them bioavailable to the skin. The result is a unique line of substantiated stone actives that enhance and protect. Mala’Kîte™ is a protective copper complex extracted from malachite. A powerful free radical scavenger, it boosts cellular defenses offering protection against aging and detoxifying benefits. Mala’Kîte™ effectively protects both skin and hair against environmental stress. See the other actives in this Mineral Matters™ line:
Once used as an ore to produce copper, today malachite is more well known as a gemstone. This beautiful stone has a green color that does not fade over time or through exposure to light, ranging from a pastel blue-green all the way to a dark green verging on black.
\n
\n
\n
The stones used to create Mala’Kîte™ liquid stone extract are sourced in central Africa. Preservative free.
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Antioxidant
\n
Detoxifying
\n
Protects skin and hair from environmental stress
\n
Natural and stable colorant
\n
\n","applications":"
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Skin care—day and night products
\n
Anti-aging and antipollution lines
\n
Hair care—protective treatments
\n
Sun care—aftersun products
\n
Spa lines
\n
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Merci pour l’intérêt que vous portez à notre entreprise.
\n
Dans cette section, vous trouverez les derniers communiqués de presse, les photos et les vidéos publiés par Gattefossé et sa Fondation d’entreprise.
\n
\n\n
\n\n
\n
Vous avez des questions ? N’hésitez pas à nous contacter pour tout complément d’information.
Gattefossé développe et produit des ingrédients de spécialité pour les industries cosmétique et pharmaceutique. Spécialiste de la chimie des lipides et de l’extraction végétale, Gattefossé propose également son expertise en formulation approfondie dans ses laboratoires d’applications.
\n
Gattefossé commercialise ses produits dans plus de 60 pays grâce à ses 12 filiales et son réseau de distribution qui assurent un support technique et marketing solide à ses clients : 75% de ses ventes sont réalisées à l’export.
\n
Innovation, qualité, stabilité et éthique sont les valeurs clés de l’entreprise depuis sa création.
\n
Gattefossé a été fondée à Lyon, France, en 1880 par M. Louis Gattefossé. Depuis sa création, l’entreprise est indépendante et gouvernée par les familles fondatrices et elle emploie plus de 300 personnes dans le monde.
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A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier in topical formulations to improve stability of emulsions.
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Oleoyl polyoxyl-6 glycerides
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Oleoyl macrogol-6 glycerides
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DRG3KJZ1TJ
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APRICOT KERNEL OIL PEG-6 ESTERS
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Polyoxylglycerides
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Consists of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of oleic (C18:1) acid
Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal cream Safety of use is supported by substantial toxicological data and precedence of use in approved pharmaceutical products.
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16:50:27","post_date_gmt":"2017-02-01 16:50:27","post_content":"","post_title":"Product Finder Pharmaceutical","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pharmaceuticals-product-finder/product-finder-pharmaceutical","to_ping":"","pinged":"","post_modified":"2021-12-20 17:02:15","post_modified_gmt":"2021-12-20 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deviation for fast and accurate measure of HLB"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"PIT deviation for fast and accurate measure of HLB"},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"PIT deviation for fast and accurate measure of HLB ","introduction":"HLB (hydrophilic lipophilic balance) is a critical parameter used to characterize surfactants. \r\nThe historical practical method still in use has major drawbacks: operator dependent as it relies on a visual assessment, room temperature dependent, not accurate, as values are given ±1 and time consuming: at least 1 day for 1 HLB measurement. \r\nA new method (PIT-deviation) has been developped in our R&D laboratory to overcome these drawbacks.","":false,"content":[{"wysiwyg":"
A new method to gain time and accuracy
\n
It relies on the concept of Phase Inversion Temperature (PIT) introduced by Shinoda et al. in 1967. The continuous phase of a direct emulsion is water, whereas it is oil for reverse emulsion. As conductivity is nil in oil and not in water, a sudden drop in conductivity indicates an inversion of phase of the emulsion.
\n
For practical purpose, NaCl brine is used as aqueous phase to have higher values of conductivity and n-octane as oily phase to enable measures around room temperature avoiding crystallization and evaporation. While increasing the temperature, the conformation of the ethoxylated surfactant changes (change in packing parameter), leading to an inversion of the emulsion which can be evaluated by the drop in conductivity. This is the Phase Inversion Temperature.
\n
\n
When introducing a second surfactant to the system, it settles at the interface of the emulsion next to the first one and the global packing parameter changes, hence the emulsion organization. This induces a deviation in the PIT value which is proportional to the mass fraction of the surfactant. Depending on the nature of the surfactant the slope can be positive (eg Sodium lauryl sulfate), nil (eg Tefose® 1500) or negative (eg Emullium® mellifera).
\n
\n
Using a range of surfactants, a correlation (r²=0.99) could be established between the HLB using the conventional method and the new PIT-deviation method.
\n
\n
The main advantages of this PIT-deviation method are:
\n
\n
Automated method with the use of an in-house designed software
\n
Rapidity: 3 hours (vs 1 day for conventional method)
\n
Accuracy of the method as it is non-operator dependent
\n
\n
\n"},{"wysiwyg":"
A (generous) slice of scientific background
\n
Surfactants are compounds that lower the surface tension (or interfacial tension) between two liquids. They are constituted of an hydrophilic part and an hydrophobic part.
\n
Surfactants with strong affinity for water form a direct emulsion (oil-in-water, O/W), whereas surfactants with strong affinity for oil form a reverse emulsion (water in oil, W/O).
\n
The surfactant spatial conformation depends on the chemistry of both parts and is characterized by the packing parameter. Note that the packing parameter is not a constant and is affected by the temperature, the solvent, the ionic strength, etc.
\n
The spatial conformation (i.e. the packing parameter, PP) of the surfactant at the interface of the two liquids orientates the emulsion organization:
\n
\n
PP<1: O/W emulsion
\n
PP ≈ 1: bi-continuous phase
\n
P>1: W/O emulsion\n
To characterize surfactants, the concept of Hydrophilic Lipophilic Balance (HLB) was first developed in 1946 by Griffin et al. Equations were established to calculate the HLB from characteristics of the surfactant such as molar mass of the hydrophilic part, molar mass, saponification value and acid value of the acid. Davies et al. (1957) proposed an extended equation for complex surfactant, taking into account constants for each substitution group. However, both methods lead to different values and for more sophisticated surfactants the equations could not be employed.
\n
Therefore, a practical method was developed to measure HLB using two reference surfactants for which both equations lead to similar values: Tween 80 (HLBTween80 ≈ 15) and Span 80 (HLBSpan80 ≈ 4) and knowing that the HLB of a mixture of surfactants is proportional to the mass of each surfactant:
\n
\n
First, a range of emulsions is prepared in standardized conditions, using 20% paraffin oil, 75% water and 5% of a mixture of Span:Tween at specific ratios (100:0, 82:18, …, 0:100). The stability of the emulsion is observed. When no or limited creaming is observed it corresponds to the HLBrequired, 10 in these conditions.
\n
\n
\n
Then, the same protocol is used with an unknown surfactant to determine its HLB. If the surfactant has an affinity for water, it will be mixed with Tween 80. If it is for oil, it will be mixed with Span 80. In the case of Tefose® 1500 below, its HLB is evaluated with Tween 80.
\n
\n
Using the above equation and knowing the relative proportion of Tefose® 1500 and Tween 80 used for the stable emulsion C, the HLB of Tefose® 1500 can be deduced:
\n
\n
Although this practical method has been used for decades to determine HLB, there are some major drawbacks due to the facts that it is:
\n
\n
operator dependent as it relies on a visual assessment
\n
room temperature dependent
\n
not accurate, as values are given ±1
\n
time consuming: at least 1 day for 1 HLB measurement
\n
\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/16951"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=16951"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/16951/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=16951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=16951"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=16951"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"sensorial-analysis-pharmaceuticals":{"id":3654,"date":"2017-04-28T08:49:03","date_gmt":"2017-04-28T08:49:03","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3654"},"modified":"2017-09-11T15:41:52","modified_gmt":"2017-09-11T13:41:52","slug":"sensorial-analysis-pharmaceuticals","status":"publish","type":"page","link":"https://www.gattefosse.com/merieux-foundation/pharmaceuticals-special-content/sensorial-analysis-pharmaceuticals/","title":{"rendered":"Sensorial analysis"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Sensorial analysis","introduction":"Poor adherence to topical treatment is a serious problem with several contributing factors. Numerous studies have shown that poor texture and sensorial properties negatively impact patient experience and adherence to treatment. The good news is there is plenty of scope for innovation and improvement in topical dosage forms if the patient’s experience of texture and sensorial properties is taken into consideration during formulation development. \r\n \r\nSensory analysis is a scientific discipline that applies the principles of experimental design and statistical analysis to measure, analyze, and interpret the characteristics of a product as they are perceived by the senses. \r\n \r\nGattefossé has developed validated methods and established an in-house sensorial analysis panel. Using this approach, we can evaluate the sensorial properties of our prototype formulations to \r\n•\tevaluate the influence of new raw materials in formulation, \r\n•\tevaluate the main texture characteristics of our emulsifiers, \r\n•\tcompare prototypes with market references, \r\n•\tunderstand market preferences, \r\n•\tconstruct a broad texture database. \r\n","":false,"content":[{"wysiwyg":"
A trained panel and validated methods for reliable results
\n
\n
Our sensory panel brings together over a dozen trained staff members, both men and women. They test new formulations approximately twice a week. The assessments are carried out using specific protocols and standardized procedures, and the results are statistically analyzed.
\n
Tests cover vision and touch, and they evaluate the following criteria:
\n
\n\n
\n
Initial touch \n
\n
pick-up
\n
texture
\n
creaminess
\n
\n
\n
\n
\n
During application\n
\n
spreadability
\n
tackiness
\n
play time
\n
greasiness
\n
softness
\n
absorption
\n
\n
\n
After absorption\n
\n
residual film
\n
tackiness
\n
greasy after-feel
\n
soft after-feel
\n
shine
\n
\n
\n
\n\n
\n"},{"wysiwyg":"
The power of sensorial mapping
\n
\n
\n
\n
This sensorial map shows the results with cream formulations formulated with different Gattefossé pharmaceutical-grade emulsifiers. It enables direct and visual comparison and can help to select the emulsifier or appropriate prototype formulation.
\n
Click on the image to enlarge.
\n
\n
For more information on how to develop formulas for optimized texture and sensory properties, please see our topical formulation section.
\n
\n
\n
\n
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Trouvez l’inspiration avec les dernières formulations développées par notre laboratoire d’applications.
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ARE INVITED!","description":"Come along, We'll take you on a tour of our cell culture laboratory!","content":"
Cosmetic actives are more than “just ingredient”. They are key contributors to cosmetic claims, helping brands to support their marketing concept, differentiate from competition and inspire their final consumers.
\n
At Gattefossé, we are focusing on extracting the very best of nature and delivering scientifically proven skin care benefits.
\n
But no claim possible without a solid substantiation file!
\n
\n
Internalized in vitro testing
\n
\n
Along with the development of the range of active ingredients and the increasing pace of innovation in this field, the need for in-house testing capabilities has become central for Gattefossé. A cell biology laboratory was opened at the headquarters in 2013.
\n
This laboratory is a space designed to integrate the entire chain of in vitro tests, from the cell culture to the proof of efficacy, including the development of models. A high value facility to run our own research in skin biology and better understand skin physiopathology.
\n
\n
Follow the guide \n
\n
\n
Pass through the entry doors with a guide who will make you discover the different spaces and equipments.
\n
Meet with the research team dedicated to cutaneous biology. Its members collaborate to create ever more advanced models of investigation.
\n
Click on the picture below to access the visit.
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Providing texture and stability
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A short video to explain how Gattefossé all-in-one emulsifiers help simplify topical formulations and enable to obtain a wide range of sensorial textures
A short video to understand the three formulation rules, ie solubility, partition, diffusion, for safe skin penetration enhancement with Gattefossé solubilizers. \n
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Transcutol® P: A high-purity solvent and powerful solubilizer associated with skin penetration enhancement in topical dosage forms.
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Lauroglycol™ FCC: Cosurfactant and solubilizer in topical dosage forms associated with skin penetration enhancement.
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Patches are efficient systems to deliver drug to and through the skin. A permeation enhancer is often used to help the percutaneous passage of the drug. With a very high solubilizing capacity for both CBD and THC, Transcutol® P is the ideal permeation enhancer.
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The mechanism of action of Transcutol® P for penetration and permeation enhancement can be explained as follows:
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Increasing drug solubility in the vehicle Increasing drug solubility and partitioning in the stratum corneum
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Maintaining hydrated dynamics in the stratum corneum without disturbing the lipid bilayer structures
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More information on the use of Transcutol® P for transdermal patches is available:
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Maisine® CC, a unique pharmaceutical oil for solubility and oral bioavailability enhancement
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October 2016
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This white paper features Maisine® CC (glyceryl monolinoleate NF), a unique pharmaceutical oil that has a long and successful history of use in lipid-based formulation for drug solubilization and oral bioavailability enhancement.
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Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API
The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications.
The objective of this study was to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release tablets containing tramadol HCl.
Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.
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Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane and Delphine Marchaud. Drug Dev Ind Pharm. 2015 Feb 5.
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This study demonstrates how a wet granulation with Compritol® 888 is an effective approach to improve material flow and compressibility. High-dose lipid matrix tablets with sustained release profiles were successfully produced.
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Note that the Pharmaceutical section of the website is in English only. (Notez que la section Pharmacie du site est en anglais uniquement). \n
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The cosmetic and pharmaceutical industries are subject to strict rules that vary from place to place and are constantly changing. To ensure full product compliance, we stay abreast of all such regulatory developments.
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Products compliant with cosmetic and pharmaceutical regulations
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As we exclusively serve the cosmetic and pharmaceutical markets, our dedicated team of regulatory experts specialized in these sectors provide solid operational support to our customers during all phases of project development.
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We constantly monitor legislation and pharmacopoeias to ensure our ingredients remain in compliance. Gattefossé products come with all the guarantees they need for registration in our customers’ regions to accelerate market release.
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Each ingredient comes with extensive and regularly updated documentary support compiling all the data and specifications required for its evaluation—i.e., certificates and technical, regulatory, and toxicological documents. Technical and safety data sheets for our products are available on our website through a user account.
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Proactive approach to industry regulatory changes
\n\n
Our membership of several professional associations—and regular participation in their workshops—allows us to closely monitor the shifting international regulatory landscape for the cosmetic and pharmaceutical industries. Through this anticipatory and collaborative approach, we actively contribute to the establishment of new guidelines and prepare for the impact these regulatory developments may have on our business and that of our customers.
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A nonionic oil-in-water emulsifier for topical formulations that provides high stability in topical fluid lotions and light emulsions over a wide pH range.
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Mixture of PEG-6 stearate and PEG-32 stearate
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Pending
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8LQC57C6B0 33GX5WQC0M
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PEG-6 STEARATE PEG-32 STEARATE
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Polyoxylethylene stearates
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Chaque jour, la peau est soumise à de multiples agressions causées par le soleil, les températures trop extrêmes, la pollution. Ces agressions sont responsables d’inflammation et de dommages cutanés.
\n
La résolution de l’inflammation est une étape cruciale afin d’éviter que les désordres inflammatoires ne deviennent permanents mais elle a été négligée jusqu’ici en soin de la peau.
\n
Gatuline® Skin-Repair AF améliore la synthèse des médiateurs spécialisés de la résolution de l’inflammation et prévient ainsi l’inflammation chronique induite par l’âge, appelé aussi Inflamm’aging. La peau est mieux armée pour faire face à l’inflammation, elle se régénère plus efficacement et le retour à l’homéostasis cutanée des peaux stressées ou endommagées est accéléré.
Gatuline® Skin-Repair AF est un actif cosmétique certifié COSMOS, extrait des parties aériennes fleuries d’Onopordum Acanthium. La plante est cultivée au centre de la France, dans une exploitation gérée dans le respect de la nature et de la biodiversité, suivant les principes écologiques de l’agriculture de conservation.
\n
Gattefossé s’est engagé à soutenir son producteur pour lui permettre de développer son activité et ses pratiques agricoles durables.
Gatuline® Skin-Repair AF optimise le processus de renouvellement de l’épiderme et répare la fonction barrière: \n \n
\n
Stimule la différentiation kératinocytaire (in vitro)
\n
Préserve la fonction barrière (in vitro / in vivo)
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\n
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Combat l’inflammation
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Stimule la résolution finale de l’inflammation
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Stimule la reconstruction optimale des peaux sèches ou abîmées
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Restaure la barrière cutanée
\n
Préserve la peau de la déshydratation
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Soin visage : anti-âge et hydratants pour peaux matures, crèmes pour peaux sèches ou sensibles
\n
Traitements contre les coups de soleil
\n
Soin du corps pour peaux abîmées
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A gel formulation includes a gelling agent—carbomers, hydroxyethyl cellulose, and hydroxypropyl cellulose are the most widely used—and solubilizers. Depending on the excipients used, a gel can be transparent (most common), translucent, or opaque.
\n
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The challenge when developing a gel is to keep the drug in a solubilized state and to identify the right gelling agent. Thus the selection of appropriate solubilizer is very important and must be compatible with the gelling agent.
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\n
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Transcutol® P is compatible with all types of gelling agents and can be used at a very high concentration in the gel without altering its structure. Clear gels are obtained.
\n
Labrasol® is compatible with all types of gelling agents. Depending on the concentration, clear or opaque gels are obtained.
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Capryol® PGMC produces an opaque gel when used at <6% with hydroxypropyl cellulose.
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Transcutol® P is widely used as solubilizer in gels, creams and emulgels.
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A simple emulgel formulation with high level of Transcutol® P can be obtained.
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Hard fat suppository base with modified monoglyceride content recommended for hydrophilic APIs requiring fast release.
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As consumer interest in natural cosmetics continues to grow, the importance of natural actives as a key part of cosmetic formulations increases as well. Today’s consumer expects powerful efficacy from natural products. The challenge therefore becomes to find extraction methods that are both natural and effective in extracting the key active molecules from plants. NaDES is a new solution, adopted by Gattefossé, to create new, natural, and highly functional active ingredients.
\n
When extracting active metabolites from plants, some molecules are more challenging than others. Despite perfect solubility in plant tissues, many of these molecules are poorly soluble in water, lipids, and even the most efficient known solvents. Additionally, traditional solvents such as butylene glycol are no longer acceptable to many consumers.
\n
Today, there is an important need for green and bio-based solvents that improve sustainability and reduce the impact on the environment.
\n
\n
NaDES, the “natural” solution
\n
\n
Recently, a new category of solvents has been discovered that is directly inspired by the way in which metabolites are solubilized inside the plant – through eutectic combinations of simple chemicals such as sugars, nitrogen compounds, and organic acids.
\n
Working with researchers from Leiden University, Gattefossé has developed and patented several natural eutectic solvents suitable for use in cosmetics, using all-natural components such as fructose, glycerin, and water. This exciting new class of solvents is natural, safe, and allows us to extract exciting new activity from plants.
\n
\n
But what does NaDES mean?
\n
\n
\n
“A eutectic mixture is defined as a mixture of two or more components which usually do not interact to form a new chemical compound but which, at certain ratios, inhibit the crystallization process of one another resulting in a system having a lower melting point than either of the components.”1
\n
A NaDES can be defined as a eutectic mixture formed by a combination of natural molecules with specific molar ratio. At the eutectic ratio, the mixture is a homogenous liquid characterized by a supramolecular structure.
\n
\n
Let’s see some results!
\n
\n
Our newest active, Gatuline® Link n Lift takes advantage of NaDES technology to bring improvement to the eye contour – visibly reducing difficult to erase under-eye and tear-trough wrinkles.
\n
As an example, the chart below shows the efficacy results of both traditional and NaDES solvents on Type IV collagen. You can clearly see that, in this case, combining a NaDES solvent with white chestnut flowers yielded the best results.
\n
\n
\n
NaDES technology and Gattefossé
\n
\n
Gattefossé has obtained rights to develop and commercialize cosmetic active ingredients obtained using the highly innovative NaDES technology.
\n
Natural, non-toxic and efficient at low temperatures, the NaDES technology is perfectly aligned with the Gattefossé strategy to provide high-performance sustainable ingredients with positive environmental impact.
\n","box_links":[],"useful_links":[{"text_link":"Gatuline® Link n Lift","link":"https://www.gattefosse.com/personal-care-actives/gatuline-link-n-lift/","external_link":""},{"text_link":"Webinar on NaDES technology","link":false,"external_link":"http://gattefosse.us2.list-manage.com/track/click?u=b900a35c2bd73bcf4590d0fe5&id=a6ae0499bb&e=a85a7e2a64"}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":false,"description":"","view_all":"personal-care/trends-education-inspiration/","filter_categories":["expertise"]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2527"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=2527"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2527/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=2527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=2527"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=2527"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"measuring-saturation-solubility-in-lipid-excipients":{"id":17836,"date":"2019-12-03T10:04:45","date_gmt":"2019-12-03T08:04:45","guid":{"rendered":"https://www.gattefosse.com/?page_id=17836"},"modified":"2021-01-20T12:38:18","modified_gmt":"2021-01-20T10:38:18","slug":"measuring-saturation-solubility-in-lipid-excipients","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-special-content/measuring-saturation-solubility-in-lipid-excipients/","title":{"rendered":"Measuring saturation solubility"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Measuring saturation solubility in liquid and solid lipid excipients, a key step in lipid based formulation (LBF) development"},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Measuring saturation solubility in lipid excipients","introduction":"Obtaining solubility data in a sufficiently broad range of lipid excipients is the first step towards the development of a lipid-based formulation. Solubility is an indication of expected drug load and performance of the formulation. ","content":[{"wysiwyg":"
Solubility testing: part of the LBF development
\n
\n
A systematic approach is recommended to develop lipid-based formulations:
\n
\n
Assessing the solubility of the drug in various excipients
\n
Evaluate miscibility and dispersion of selected excipients for ternary diagramming
\n
In vitro lipolysis testing
\n
\n
For more information:
\n
\n
\n
\n
A Systematic Approach to Lipid-Based Formulation Development for a Poorly Soluble API, Fenofibrate \n Masumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph. \n Download the poster
\n
\n
\n
\n"},{"wysiwyg":"
Measuring saturation solubility
\n
Principle
\n
The solubility of a solute (API) in a solvent (lipid excipient) is measured as the saturation concentration, i.e. when adding more solute does not increase the concentration of the solution and the excess amount of solute begins to precipitate.
\n
In liquid excipients crystals can easily be observed when saturation solubility is attained, whereas for solid and semi-solid lipid excipients techniques such as differential scanning calorimetry (DSC) and/or hot stage microscopy (HSM) are required
\n"},{"wysiwyg":"
Measuring saturation solubility in liquid lipid excipients
\n
\n
In liquid excipients, solubility data can be obtained by the equilibrium solubility method at ambient temperature and is evaluated using (Ultra) High Performance Liquid Chromatography (UPLC/HPLC).
\n"},{"wysiwyg":"
Measuring saturation solubility in solid and semi-solid lipid excipients
\n
\n
Two methods can be used, alone or in combination, to estimate drug solubility in solid and semi-solid lipid excipients: Differential Scanning Calorimetry and/or Hot Stage Microscopy.
\n"},{"wysiwyg":"
Measuring solubility with Differential Scanning Calorimetry (DSC )
\n
A depression in melting enthalpy of the solid solvent is observed as the solute is solubilized in the solvent. As the concentration of the dissolved solute increases, the energy required to melt the solvent falls until saturation solubility is attained. At concentrations above the saturation solubility, the depression in the melting enthalpy is not observed, and a break in the downward trend is seen.
\n"},{"wysiwyg":"
Measuring solubility with Hot Stage Microscopy (HSM)
\n
Crystalline materials exhibit birefringence under cross polarized light. If the drug is completely solubilized in the excipient, no birefringence is exhibited at temperatures above the melting point of the excipient. However, at concentrations above saturation solubility, birefringence is observed at temperatures above the melting point of excipient because the drug is not completely solubilized. Based on this information, the range for saturation solubility of the drug in the excipient is determined.
\n
Left picture: 375 mg ibuprofen / g Gelucire® 50/13 : no crystal \n Right picture: 400 mg ibuprofen / g Gelucire® 50/13 : crystal \n Hence, limit of solubility for ibuprofen in Gelucire® 50/13 is 375 mg/g
\n
\n"},{"wysiwyg":"
For more information
\n
Ask for our detailed method
\n
\n
\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/17836"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=17836"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/17836/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=17836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=17836"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=17836"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"fighting-urban-pollution":{"id":2514,"date":"2017-04-21T10:25:03","date_gmt":"2017-04-21T10:25:03","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2514"},"modified":"2019-05-03T11:06:43","modified_gmt":"2019-05-03T09:06:43","slug":"fighting-urban-pollution","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-trend/fighting-urban-pollution/","title":{"rendered":"Fighting Urban Pollution"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Fighting urban pollution with the help of smart textures and actives","_yoast_wpseo_metadesc":"Pollution is a global concern and a major source of skin damage! Discover Gattefossé solutions for innovative and efficient anti-pollution skin care."},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"Fighting Urban Pollution","content":"
Pollution – a global concern and a major source of skin damage.
\n\n
Airborne, pollutants, fine particles emissions, ozone, exhaust gases, tobacco smoke… Pollution is an environmental concern for people throughout the world and causes disease and illness, especially in industrial and urban areas.
\n
\n
88% of Earth population lives in areas where air quality does not meet OMS norms. (Olay Report)
\n
20 to 30% of urban population is exposed to superior concentration of fine particles
\n
\n
\n
Impact on the skin
\n
\n
Each day, our skin is dramatically challenged. Pollution is today one of the main sources of skind amage causing skin to age prematurely. Air pollutants disrupt the natural balance of the epidermis. The effects of a long-term exposition to pollution have been largely described.
\n
\n
Protect your skin
\n
\n
\n
Create a barrier with protective textures. This will create an efficient anti-pollution shield and prevent pollutants from adhering to the epidermis.
\n
Neutralize with antioxidant actives. They are the answer to prevent and reduce damage caused by free radicals.
\n
Clean with gentle textures, to remove the film of pollutants, makeup, dirt and sweat.
\n
\n
\n
A natural and efficient shield against pollution: Emulium® Mellifera MB.
\n
\n
\n
\n
Created from natural ingredients, Emulium® Mellifera MB is composed of beeswax and jojoba wax, bringing softness, comfort and protection to the skin. Draped in a soft and imperceptible veil, the skin is protected from external aggressions.
\n
An effective triple action against urban pollution:
\n\n
The film created at the surface of the skin prevents a large part of urban dusts and particles from adhering to the epidermis.
\n
The film also traps the pollutants and prevents them from penetrating into the skin.
\n
These pollutants are eliminated with the film during makeup removal / face cleansing.
\n\n
Emulium® Mellifera MB, the breathable shield. Proven efficacy in vitro and in vivo
\n
\n
Real barrier effect (-32% adhesion of particles vs untreated)
\n
Better cleansing and elimination of particles
\n
Protective effect : +19%
\n
\n
To learn more about urban pollution and Gattefossé’s urban textures and smart actives, download our thematic booklet in the right column of this page.
\n
\n
\n
Discover our best anti-pollution formulas
\n
Download the formula sheets in the “Related documents” box in the right column.
\n
\n
Anti-Pollution Cream SPF 15 (1538-2.01)
\n
Yoga Serum (1532-1.12)
\n
Urban Shield Cream (1933-1.01)
\n
Sublime Soothing Cream (1574-1.01)
\n
\n
\n","box_links":[],"useful_links":[{"text_link":"Emulium® Mellifera MB","link":"https://www.gattefosse.com/personal-care-textures/emulium-mellifera-mb/","external_link":""},{"text_link":"Gatuline® Age Defense²","link":"https://www.gattefosse.com/personal-care-actives/gatuline-age-defense-np/","external_link":""},{"text_link":"Gatuline® Renew","link":"https://www.gattefosse.com/personal-care-actives/gatuline-renew/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":13938,"alt":"","title":"urban-pollution","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/urban-pollution-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"description":"","view_all":"personal-care/trends-education-inspiration/","filter_categories":["ingredient-highlights"]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2514"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=2514"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2514/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=2514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=2514"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=2514"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"beauty-beyond-natural":{"id":5294,"date":"2017-06-12T08:46:08","date_gmt":"2017-06-12T08:46:08","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=5294"},"modified":"2019-05-03T11:01:50","modified_gmt":"2019-05-03T09:01:50","slug":"beauty-beyond-natural","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-trend/beauty-beyond-natural/","title":{"rendered":"Beauty beyond natural"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Beauty beyond natural: Formulating natural cosmetics","_yoast_wpseo_metadesc":"With consumers’ enthusiasm for naturalness and wellness, the challenge for the formulators is to find solutions to match their own functional constraints."},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"Beauty beyond natural","content":"
It’s not worth saying that naturality is a major trend in cosmetics.
\n
\n
According to Mintel, the sales of natural and organic personal care products records a 8.5% growth in 2016 (Vs 2015) in the US natural supermarkets (1). But consumers’ definition about what’s is “natural” is constantly evolving, even deriving towards an exacerbated version of naturality.
\n
And let’s admit that beauty brands are forced to follow the rhythm.
\n
\n
There have been the “free from” claims
\n
\n
0% perfume, preservatives, silicones, sulfates…
\n
They started to appear more than 10 years ago with suspicions around parabens and since that time, they continue to expand their territory, feeding by growing consumers’ concerns for their health and wellness.
\n
Whereas chemical compounds were at the origin of all the worries, targets changed and nowadays, even natural ingredients can be disputed.
\n
While boundaries between food and skin care blur, diets and lifestyle principles spread to the beauty world, giving birth to new “free from” requirements.
\n
\n
\n
\n
The new nasties
\n
\n
One example is the vegan cosmetics.
\n
From its beginning in the mid. 20th century, the vegan diet never stop expanding. Between 2009 and 2014, the number of followers has been multiplied by 2 in the US, by 3 in the UK.
\n
Moreover, more and more consumers are worried about the composition of personal care products, and as a consequence tend to exclude animal based ingredients of their beauty basket. Thus, vegan claims gain popularity. In 2010, Mintel counted 1.5% of skin care launches featuring a mention “suitable for vegetalians”. The percentage reached 3.6% in 2016. (2)
\n
Another diet gets wider echo in cosmetics. Gluten free claims were first dedicated to the food industry, aiming at offering food alternatives for people suffering from celiac diseases or sensitivity to gluten.
\n
Nevertheless, the growing awareness regarding gluten intolerances gave birth to a more holistic approach for people looking at reducing their consumption, encouraging them to look at beauty products free from the protein even if cosmetics do not contain gluten naturally.
\n
These 2 movements benefited from great media coverage over the last few years as well as celebrities’ endorsement who publicly communicated on the benefits of such diets. We can thus easily think that generation Z will continue to follow the movement.
\n
\n
\n
What will be the next target?
\n
\n
With the rise of allergies prevalence, we may see the global claim “free from allergens” growing.
\n
Some products already exist on the truly natural beauty segment. But such claims also raised questions regarding the definition of these “allergens”. What is an allergen and what is not? Isn’t there a risk of downward spiral if everything can be considered as potentially allergenic? Consumers’ education is probably the key.
\n
In a context where naturality has no clear contours anymore, challenge for the formulators will be to navigate within these requirements, finding alternative solutions to match their own functional constraints with consumers’ over-enthusiasm for naturalness, health and wellness.
\n
\n
\n
References
\n
(1) Mintel report: Natural and organic personal care consumer, US, December 2016
\n
(2) Mintel search: skin care products launched 2010 VS 2016
\n
Additional reference: ROSS-FICHTNER R., ROBICHAUD C., Why we will never be free from “free from” claims, Cosmetics & toiletries, july/august 2016, Vol.131, N°6
\n
\n","box_links":[],"useful_links":[{"text_link":"Beauty spot: detox, fresh and vegan beauty (Mintel.com)","link":false,"external_link":"http://www.mintel.com/blog/beauty-market-news/beauty-spot-detox-fresh-and-vegan-beauty"},{"text_link":"Gluten free beauty is on the rise (Mintel.com)","link":false,"external_link":" http://www.mintel.com/blog/beauty-market-news/gluten-free-beauty-is-on-the-rise"},{"text_link":"Vegan products, the future of cosmetics FR (Madame.lefigaro.fr)","link":false,"external_link":"http://madame.lefigaro.fr/beaute/produits-vegans-lavenir-des-cosmetiques-191016-117388"},{"text_link":"Vegan, the growing trend that knows better (Cosmeticobs.com)","link":false,"external_link":"http://www.cosmeticobs.com/news/congress-reports/vegan-the-growing-trend-that-knows-better-2639 "}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":13942,"alt":"","title":"beauty-beyond-natural","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/beauty-beyond-natural-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"description":"Formulating natural cosmetics","view_all":"personal-care/trends-education-inspiration/","filter_categories":["inspiration-trends"]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/5294"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=5294"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/5294/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=5294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=5294"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=5294"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"our-expertise":{"id":935,"date":"2017-03-06T14:05:22","date_gmt":"2017-03-06T14:05:22","guid":{"rendered":"http://217.109.87.212/front/?page_id=935"},"modified":"2019-06-06T14:53:38","modified_gmt":"2019-06-06T12:53:38","slug":"our-expertise","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-expertise/our-expertise/","title":{"rendered":"Expertise"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gattefossé's expertise | Plant extraction and lipid chemistry","_yoast_wpseo_metadesc":"For almost 140 years, successive generations of scientists have been developing Gattefossé’s know-how in plant extraction and lipochemistry. "},"categories":[30],"tags":[],"acf":{"introduction":"For almost 140 years, successive generations of scientists have been contributing to the development of Gattefossé’s know-how in plant extraction and lipochemistry. This expertise has extended throughout the years to other complementary fields with the aim to develop, produce and market first-class products and services of a consistently high quality, while leading the way for innovation and creativity. \r\n \r\n","":false,"component":"PageExpertiseCorpo","left_blocks":[{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/industrial-operations_322x173px.jpg","title":"Industrial operations","description":"A solid know-how, state-of-the-art technologies and a constant commitment to quality.","link":"https://www.gattefosse.com/corporate-content/industrial-operations/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/plant-extraction_322x173px.jpg","title":"Plant extraction","description":"High-quality actives based on plant extraction processes.","link":" 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expertise","content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/935"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=935"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/935/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=935"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=935"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"acticire-mb":{"id":1742,"date":"2017-04-29T14:45:24","date_gmt":"2017-04-29T14:45:24","guid":{"rendered":"/?page_id=1742"},"modified":"2019-05-03T15:39:00","modified_gmt":"2019-05-03T13:39:00","slug":"acticire-mb","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-textures/acticire-mb/","title":{"rendered":"Acticire® 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MB","tagline":"Active waxes","description_product_finder":"","introduction":"
Multifunctional ingredients that meet desired customer claim and ease the formulation process are becoming more and more in demand.
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The specific technology behing Acticire® MB makes it a distinct, multifunctional ingredient with several unique applications.
A 100% natural texturizing agent based on a complex of 3 functionalized waxes:
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Jojoba wax
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Sunflower seed wax
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Mimosa wax
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Jojoba wax is the only wax that is liquid at room temperature. This is due to its composition: unsaturated fatty alcohol esters combined with an unsaturated fatty acid.
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Sunflower seed wax is a hard wax made up of fully saturated monoesters that boasts excellent thermal stability
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Mimosa wax a coproduct of the perfumery industry, is not surprisingly rather sweet smelling. Softer than the other waxes, it melts at about 60 °C and has a more complex composition that includes long-chain esters, hydrocarbons, and a smaller amount of triterpenoid alcohols.
Acticire® MB is a multifunctional ingredient with several unique applications. This video illustrates how Acticire® MB can be used to introduce water based ingredients into anhydrous formulations.
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In this example, an hydrophilic dye is incorporated into the water phase to show how it is well dispersed in a lipstick with Acticire® MB.
These three waxes have been transesterified in the presence of vegetable polyglycerin, rendering them more compatible and stabler in emulsion, and confering new sensorial qualities and characteristics:
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Physical properties midway between those of liquid and solid waxes
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Softness and spreadability upon application
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Comfortable skin feel that lasts throughout the day
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\n","img":{"id":3105,"alt":"Sensory analysis at Gattefossé","title":"Sensory Analysis","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/acticire.jpg"},"video":""},{"content":"
Acticire® MB brings three different and distinctive benefits to cosmetic formulations:
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Forms a soft, smooth film that protects from dehydration
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Improves the texture and application of both standard and natural formulations
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Makes it possible to include water or water-soluble actives in anhydrous systems while allowing them to remain stable
In emulsions, can be a substitute for some low HLB co-emulsifiers
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Can emulsify up to 15% of water in an oil phase, exhibits great heat stability, allows introduction of water or hydrosoluble actives to anhydrous formulations
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Reduces transepidermal water loss, moisturizes, and improves appearance of skin surface (in vivo tests)
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Sun care—formulations with high UV filter levels (improved skin feel)
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Makeup—foundations (emulsions or gels), lipsticks, mascaras
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Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation
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Jasmine Musakhanian, Jean-David Rodier and Masumi Dave
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AAPS PharmSciTech – Vol. 23 – May 2022, Article number 151
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
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Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin
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European Journal of Pharmaceutical Sciences, Volume 137, 2019, 104967, \n ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967.
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In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
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Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
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Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
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How to avoid precipitation and create a concentration gradient to improve absorption
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Methods for modelling the performance such as Molecular Dynamics Simulations
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In vitro methods for solubility and dissolution assessments
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Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
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Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
1 Initial identification and characterization of the active ingredient \n 1.1 Physico-chemical characteristics \n 1.2 Impact of physicochemical characteristics on absorption \n 1.3 Passive diffusion prediction tools \n 1.4 In silico prediction \n 2 Biopharmaceutical classifications
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III Formulation strategies
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1 prerequisites \n 2 techniques for increasing the dissolution rate \n 3 Solubility enhancement technologies \n 4 Improving the permeability, oral route
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IV Control, assessment, prediction of the bioavailability
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1 Physicochemical control methods for the manufacturing intermediates and finished products \n 2 Assessing an dpredicting the bioavailability of the formulations
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V Alternative strategy: changing the route of administration
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
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Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd
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In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
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A review of the techniques used to characterize the colloidal structures is also carried out.
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
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Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Reaching milestones in lipid-based formulations: from effective prediction to successful development
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September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
This acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
A winterized oil composed of long-chain mono-, di-, and triglycerides for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble lipophilic APIs. Used in self-emulsifying lipid formulations (SEDDS and SMEDDS) as an oily vehicle.
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Glyceryl monolinoleate
\n"},{"keys":"EP Name","value":"
Glycerol monolinoleate
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4763AXI84L
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GLYCERYL MONOLINOLEATE
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Glyceryl monolinoleate
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Consists of mono-, di- and triglycerides of mainly linoleic (C18:2) and oleic (C18:1) acids, the diester fraction being predominant
Solubilizer for lipophilic API and bioavailability enhancer. Oily vehicle for LFCS Type I (oily), Type II (SEDDS) and Type III (SMEDDS), associated with lymphatic absorption. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
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publications"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"An exhaustive list of all the scientific publications from Gattefossé experts","_yoast_wpseo_metadesc":"Find out the scientific articles and posters written by our pharmaceutical scientists about lipid-based excipients and formulation technologies."},"categories":[63],"tags":[],"acf":{"component":"Brochures","title":"Gattefossé publications","introduction":"Find below the list of all publications (articles and posters) of Gattefossé scientists.Posters are available to download after log-in.","":false,"content":[{"wysiwyg":"
Ethanol-resistant ethylcellulose/guar gum coatings – importance of formulation parameters
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In vitro digestion of the self-emulsifying lipid excipient Labrasol® by gastro-intestinal lipases and influence of its colloidal structure on lipolysis rate
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Ethanol-resistant polymeric film coatings for controlled drug delivery
Compartmentalization of the human stratum corneum by persistent tight junction-like structures
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\n"},{"wysiwyg":"
2010
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Diluent effects on drug release from sustained release Compritol® 888 ATO tablets
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Gastro-intestinal lipolysis of lipid-based excipients intended for oral drug delivery of poorly water soluble drugs
\n
Specific assay of carboxyl ester hydrolase using PEG esters as substrate
\n
An investigation into the mechnism of dissolution rate enhancement of poorly water soluble drugs from spray chilled Gelucire® 50/13 microspheres
\n
\n"},{"wysiwyg":"
2009
\n
\n
Lauroyl polyoxylglycerides, functionalized coconut oil, enhancing the bioavailability of poorly soluble active substances
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Vaginal cream formulation for the prevention of HIV infection for women in developing countries
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In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self-emulsifying excipients Labrasol® and Gelucire® 44/14
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Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity
Bibliography on Gattefossé’s products. 2004-2005 review.
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Systèmes auto-emulsionnables et émulsions sèches [Self emulsifying drug delivery systems]
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\n"},{"wysiwyg":"
2004
\n
\n
Structural and thermal characterization of lipidic excipients and carriers by X-ray diffraction coupled to differential microcalorimetry
\n
Structural and thermal characterization of mono and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry
\n
\n"},{"wysiwyg":"
2003
\n
\n
Enhanced bioavailability of simvastatin in a self-emulsifying drug delivery system (SMEDDS)
Ethanol-resistant ethylcellulose/guar gum coatings – importance of formulation parameters
\n
In vitro digestion of the self-emulsifying lipid excipient Labrasol® by gastro-intestinal lipases and influence of its colloidal structure on lipolysis rate
\n
Ethanol-resistant polymeric film coatings for controlled drug delivery
Lauroyl polyoxylglycerides, functionalized coconut oil, enhancing the bioavailability of poorly soluble active substances
\n
Vaginal cream formulation for the prevention of HIV infection for women in developing countries
\n
In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self-emulsifying excipients Labrasol® and Gelucire® 44/14
\n
Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity
Structural and thermal characterization of lipidic excipients and carriers by X-ray diffraction coupled to differential microcalorimetry
\n
Structural and thermal characterization of mono and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry
\n","link":""}]},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/3753"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=3753"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/3753/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=3753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=3753"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=3753"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gattefosse-human-rights-commitments":{"id":19489,"date":"2020-06-05T11:55:09","date_gmt":"2020-06-05T09:55:09","guid":{"rendered":"https://www.gattefosse.com/?page_id=19489"},"modified":"2020-06-05T12:41:37","modified_gmt":"2020-06-05T10:41:37","slug":"gattefosse-human-rights-commitments","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-content/gattefosse-human-rights-commitments/","title":{"rendered":"Gattefossé Human Rights commitments"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Our commitment to Human Rights, integrity, responsibility and respect for all our partners."},"categories":[48],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCorporate","title":"Gattefossé Human Rights commitments","content":"
\n
\n
Gattefossé’s family culture is based on a deep commitment to sustainability, innovation, and service. An attachment complemented by strong values in terms of ethics and social responsibility which contribute to the group’s long-term success. In order to sustain our development, it is essential to ensure that our practices comply with the highest standards of integrity, responsibility and respect for all our partners. This respect translates into concrete commitments of responsibility, through our Responsible Purchasing Charter and our Ethics Charter. But also, a strong commitment to the Respect for Human Rights that we share within our sphere of influence.
\n
\n
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As a responsible corporate citizen and to meet the growing expectations of our business partners in terms of access to information, we believe that we can contribute to positive human rights impacts by playing our role in terms of Respect for Human Rights.
\n
\n
At the heart of this declaration, Gattefossé commits to respect the principles of Human Rights, to respect the various local laws and customs and to include these ethical principles into all interactions with the various stakeholders in its sector of activity.
\n
A declaration formalized as a common framework between Gattefossé employees and our business partners that we are committed to live and respect in our day-to-day work, everywhere in the world and at all levels of the company.
\n
\n
The detailed document is online with our commitment to the Universal Declaration of Human Rights, the United Nations Guiding Principles on Business and Human Rights, the Fundamental Conventions of the International Labour Organization and our commitments to respect these principles throughout our value chain.
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Henri-Marcel Gattefossé, chemist and son of René-Maurice, succeeded to his father at the head of the family business and ran the Gattefossé company from 1968 to 1987.
\n
His intellectual interests were embedded in chemistry, biology, healing and health.
\n
In the 1960’s, he connected with doctors and compounding pharmacists at Lyon’s hospital to understand how excipients could improve the delivery of certain active ingredients.
\n
From this experience grew the belief that the challenges of improving healthcare for patients were better solved collegially through the exchange of knowledge, experience and ideas.
\n
\n
\n
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\n
In 1966, he gathered together a small group of friends and associates – chemists, biologists, doctors, pharmacists and researchers from the pharmaceutical industry – in St Rémy de Provence and the Gattefossé’s annual scientific meetingLes Journées Galéniques of St Rémy de Provence began.
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\n
\n
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L’Académie des Alpilles, a recognition for all participants
\n\n
\n
As a pioneer of university-industry relationships, Henri-Marcel Gattefossé foundedL’Académie des Alpilles in 1966 at the same time as the first Journées Galéniques. This organization aims at gathering all academic scientists, researchers and industrials who attended to these meetings and certify them with the honorific title of “Member” of l’Académie.
\n
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So far, 693 people from 31 countries around the world have received this title in recognition to their participation to the development of scientific exchanges in galenical pharmacy.
\n
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Celebrating 50 years of scientific exchange
\n\n
In 2016, Les Journées Galéniques celebrated their 50th anniversary. Throughout the years, various topics addressing the formulation challenges in pharmacy have been discussed with the continuous ambition to inspire scientific studies and industrial innovations related to the formulation of medicines.
\n
\n
To mark this particular anniversary, the discussions focused on “Change, Perspectives & Partnerships » in galenical pharmacy in order to highlight both achievements of yesterday and challenges of tomorrow.
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Gatuline® Radiance is obtained from Evodia rutaecarpa, also known as “Wu-Zhu-Yu”, a flowering shrub member of the Rutaceae family. Evodia rutaecarpa is widely cultivated in southeast China for Traditional Chinese Medicine. In addition to its medicinal uses, the Chinese would traditionally wear Evodia on the ninth day of the ninth Chinese lunar month (Double Ninth Festival). The plant was thought to bring luck. Preservative free.
Anti-pollution (the skin is less reactive, durably soothed)
\n
\n","applications":"
\n
Alphabet creams
\n
Skin perfectors
\n
Illuminating products
\n
Global antiaging lines
\n
Lip products (reveals natural rosy color of lips)
\n
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To benefit from this label, all aspects of sustainable development must be taken into account throughout the production chain: respect for biodiversity, environmental impact…
\n
Today, we are happy to offer our customers 25 cosmetic ingredients approved by the NATRUE label. These ingredients have been added to NATRUE’s online database.
\n
NATRUE is an international non-profit association based in Brussels. Created in 2007, it is committed to the promotion and protection of natural and organic cosmetics.
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A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
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Propylene Glycol Monocaprylate NF \n[May also be labeled as Propylene Glycol Monocaprylate (type II) NF until December 1, 2026]
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/
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RT9P9S09QI
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PROPYLENE GLYCOL CAPRYLATE
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Propylene glycol monocaprylate
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Consists of propylene glycol esters of caprylic acid (C8), mainly composed of monoesters and a small fraction of diesters.
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation. Safety of use is inferred by precedence of use in approved pharmaceutical products.
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But it is also the mirror of our outer environment! Discover how it is impacted by climatic and seasonal changes"},"categories":[56],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCos","title":"Sea, Care and Sun","view_all":"personal-care/trends-education-inspiration/","filter_categories":["textures-formulations"],"content":"
The sunny days are back, and the desire to add freshness and lightness in our beauty routine too. However, heat, redness, perspiration or UV radiations may cause inconvenience and require some adjustments in the choice of cosmetic products. It is indeed essential to choose light textures that penetrate quickly and leave the skin fresh, sufficiently moisturized, nourished and protected from external aggressions.
\n
\n
\n
Refresh your skin
\n
\n
In the summer, the heat can quickly be unpleasant and cause hot flashes and redness. Light textures, refreshing but nevertheless moisturizing are essential to take care of your skin.
\n
\n
Pure Crystal Cream (2456-1.05) is a minimalist formula obtained with Emulium® Dolcea MB that contains liquid crystals thanks to its carefully developed composition . This cream has a unique sensoriality: slighlty translucent and very shiny texture, fresh and matte effect on application.
\n
\n
Ready-to-go Body Lotion (2188-1.18) is a surprising W/O emulsion formulated with a combination of Emulium® Illustro and Emulfree® CBG MB which provides a light, comfortable and evanescent texture. It instantly penetrates to deeply nourish the skin, without any sticky or greasy effect, and makes it possible to dress up just after application.
\n
\n
\n
Protect your skin
\n
\n
One of the main threats in summer is of course the sun, which can cause sunburns and premature skin aging due to a lack of sufficient protection. Moreover, sun protection is not only reserved for the beach and must be used as soon as we go outside.
\n
\n
Extremely Soft Protection SPF30 (2397-2.25) doesn’t look to be! Thanks to Emulium® Dolcea MB, the texture is soft and comfortable and leaves a very smooth, non-greasy and non-sticky afterfeel, while Solastemis protects the skin from the harmful effects of UVA and photo-aging. It can be used for daily care or for the beach.
\n
\n
Ultra-Fluid Sunscreen SPF50 (2157-1.07) protects the skin from UV rays and allows to expose safely at the beach. Thanks to Emulium® Illustro, its application is easy and fast, and the finish on the skin is soft and light. No more sand sticking to the skin!
\n
\n
Fully Mineral Sunscreen SPF30 (2078-1.13) is composed exclusively of non-nano mineral filters for protecting your skin from UV rays at the beach while protecting the environment! Unlike most natural sunscreens, its texture is soft, easy to spread, and leaves no sticky nor greasy film thanks to Emulium® Illustro. A mix of active ingredients brings energy and radiance to the skin.
\n
\n
\n
Do not forget your hair! \n
\n
\n
The hair is also affected during the summer and requires special attention. Indeed, the sun, sea salts and the wind dry the hair fiber and make it appear rough and dull. It is also important to use hair products adapted to the hair type.
\n
\n
\n
Revitalizing Hair Lotion (2433-1.02) is a light lotion for fine and straight hair that smoothes and disciplines hair without weighing it down. Formulated with Emulium® Mellifera MB, this fluid emulsion penetrates quickly into the hair fiber without leaving a perceptible film thanks to Definicire®.
Intense Nutrition Hair Balm (2435-1.02) is a nutritive balm for curly, frizzy and coily hair that leaves a soft protective film and redefines hairstyle thanks to Definicire®. Formulated with Emulium® Mellifera MB, this thick oily balm intensely nourishes the hair without any greasy afterfeel.
\n
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Foams can be produced using two distinct technologies:
\n
\n
In an aerosol using propellant gas, the formulation consists of an emulsion. The creamy foam obtained is suitable for damaged or sensitive skin (e.g., psoriasis or atopy).
\n
\n
\n
\n
In a propellant-free device, the formulation consists of a microemulsion. The light texture obtained is suitable for quick absorption without residue and is convenient for hair-bearing skin. It may, for example, be used with disinfectant or anti-inflammatory drugs.
\n
\n
\n
Excipients for propellant device emulsion formulation:
\n
Tefose® 63 is an O/W emulsifier with foaming capacity and high mucosal tolerance. It is often used in combination with Labrafil® M 1944 CS as a co-emulsifier and Transcutol® P as solvent.
\n
Excipients for propellant-free device micro-emulsion formulation:
Gattefossé can provide formulation tips for pharmaceutical foams using propellant and propellant-free devices, guidelines on how to formulate and select excipients, and case studies with model drugs.
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A glyceride with an intermediate melting point used as a matrix agent for sensitive APIs and a viscosity-increasing agent in oral and topical formulations.
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Hard fat
\n"},{"keys":"EP Name","value":"
Hard fat
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8334LX7S21
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FAT, HARD
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/
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Consists of mono-, di- and triglyceride esters of fatty acids (C8 to C18), the triester fraction being predominant
Matrix-forming agent for protection of APIs sensitive to oxidation, humidity, or light. Consistency agent in oral and topical formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.
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An oily vehicle used as solubilizer for lipophilic APIs in oral and topical formulations.
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Glyceryl monooleate (Type 40)
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Glycerol mono-oleates (Type 40)
\n"},{"keys":"UNII Code (FDA)","value":"
4PC054V79P
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GLYCERYL OLEATE
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Glyceryl monooleate
\n"},{"keys":"Chemical description","value":"
Consists of mono-, di- and triglycerides of oleic (C18:1) acid, the monoester fraction being predominant
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EnergiNius® protège les cellules de la peau de la lumière visible artificielle émise par les écrans, un stress environnemental additionnel induit par notre mode de vie moderne.
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Fortement renforcée, la peau est visiblement ravivée et les signes de fatigue disparaissent pour un teint plus lumineux et éclatant.
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Issu des racines de Ginseng Indien (Withania somnifera), EnergiNius® est certifié bio et obtenu grâce à la technologie innovante des NaDES. Sourcée en Oregon (USA), Withania somnifera est une plante emblématique de la médecine Ayurvédique et est utilisée en médecine traditionnelle depuis des siècles.
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Watch the video to get a comprehensive overview of EnergiNius®: \n
For the first time, the screen emitted artifical visible light (AVL) has been precisely characterized and Gattefossé has developed unique equipment accurately recreating the light emitted by screens.
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1,3-Propanediol is an excellent natural alternative to petroleum-based glycols (propylene glycol, butylene glycol, or methyl propanediol) and glycerine. In cosmetics, 1,3-Propanediol is a multipurpose ingredient, acting as an emollient, humectant, booster, solvent, viscosity enhancer, and carrier for actives. 1.3-Propanediol is also miscible with the majority of glycols and alcohols, as well as water, and gives better performance in both skin and hair moisturization when compared to standard glycols. Well suited to sensitive skin, even at high concentration, 1,3-Propanediol meets the many standards of modern cosmetic formulations.
\n
The agreement, which is effective immediately, will allow Gattefossé to expand its natural product offering for Canadian customers.
\n
«As a well-known supplier of naturally based ingredients, the philosophy of our company fits well with that of Connect Chemicals. Adding propanediol to our Canadian portfolio allows us to bring a more rounded natural offering to our customers in the region», states Eric Brun, President & CEO of Gattefossé USA & Canada.
\n
\n
Connect Chemicals has a special focus on cosmetic raw materials from renewable and sustainable sources, offering a wide range of COSMOS/ECOCERT certified products.
\n
Glory Biomaterial Industry is a worldwide market leader in bio-based chemicals. Glory developed its proprietary and patented process for the production of 1,3-Propanediol (COSMOS/ECOCERT certified) from renewable sources that are GMO-free. Glory is a proud member of RSPO (Roundtable on Sustainable Palm Oil) as a sign of its strong commitment towards the environment.
\n
\n
On the picture from left: Dario Monti, Product Manager, Connect Chemicals; A. Başar Karaca, Managing Director, Connect Chemicals; Eric Brun, President, Gattefossé USA & Canada; Carl Philipps, Vice President Operations, Gattefossé Canada
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Definicire® est un agent texturant actif qui recrée la couche lipidique protectrice des cheveux.100% naturel, à base de cires fonctionnalisées de graines de jojoba et des coques de graines de tournesol, il assure une discipline de cheveux parfaite dans tous les climats et une sensation de douceur et de confort.
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Des cheveux en bonne santé sont hydrophobes.Definicire® renforce l’hydrophobie des cheveux.Il agit comme un lubrifiant en les protégeant de l’humidité et des frisottis, dans des conditions sèches ou humides.
Consistency agent for oily phase in topical formulations. Stability-improving agent. Safety of use is inferred by precedence of use in approved pharmaceutical products.
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Nature is a constant inspiration for cosmetics ingredients, but plants are not the only sources of natural actives. Mineral Matters™ liquid stone extracts apply special technology to extract important minerals from precious stones and make them bioavailable to the skin. The result is a unique line of substantiated stone actives that enhance and protect. Zin’Cîte™ is a zinc complex extracted from smithsonite that offers long-term protection by shielding DNA and preventing glycation. See the other actives in this Mineral Matters™ line:
Smithsonite is a 100% natural zinc carbonate (ZnCO3) stone sourced in Mexico. Characterized by a silky or pearly luster, this stone can reflect light or appear transparent, depending on the specimen. Smithsonite can be found in different colors, from turquoise to pink.
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A unique process allows us to obtain a stable, bioavailable zinc-rich liquid active from smithsonite. Preservative free.
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Jacques Moyrand (President), Eduardo De Purgly has been taking over Oliver Midler’s position as CEO of Gattefossé group since the 1st January 2018.
\n
\n
1st image, from left to right : Jacques Moyrand, Olivier Midler, Eduardo De Purgly and Thierry Magnet. 2nd image : Eduardo De Purgly. \n
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Today’s cosmetic products require flexibility and innovation, as well as simplicity. Consumers today are placing a higher emphasis on health and wellness, marked by a strong return to traditional values and natural sources. Obtained from beeswax, Apifil® CG is a moisturizing emulsifier that can be used for a wide range of cosmetic formulations, offering pleasant spreadability and ease of application, while contributing to skin hydration.
O/W emulsifier, made from natural beeswax, Apifil® CG promises efficacy in complete harmony with the skin. Beeswax helps to increase emulsion viscosity and improve spreadability. It enriches the oil phase of emulsions and improves after-feel, while also contributing to skin hydration by reducing moisture loss through the creation of a protective lipid film.
Lotions, supple creams, thick creams, and butters:
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Skin care—day and night applications
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Hair care—treatment masks, styling waxes
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Makeup—mascaras, foundations, lipsticks, pencils
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Sun care—protective sunscreen creams, aftersun preparations
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Barrière physique entre l’intérieur et l’extérieur du corps, la peau est l’un des organes les plus réactifs aux agressions extérieures, en particulier au rayonnement UV. En pénétrant au plus profond des cellules cutanées, dans l’ADN, les UVs sont responsables d’altérations structurelles et fonctionnelles des différentes couches de la peau.
\n
Solastemis™ agit au coeur de la mécanique de l’épiderme, en protégeant l’ADN des kératinocytes des rayons UVA et en boostant le système naturel de réparation de l’ADN. Il préserve les cellules souches épidermique assurant une bonne homéostasie de la première ligne de défense de la peau. \n Il offre également un bouclier pour le derme en protégeant les protéines clés de la matrice (collagène, élastine) de la dégradation induite par les UVA.
\n
Les symptômes de photovieillissement sont visiblement corrigés : les rides sont réduites, le microrelief est lissé, le teint est plus lumineux, plus uniforme et plus sain.
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Solastemis™ est issu de la chayote (Sechium edule), un fruit cultivé et récolté manuellement selon les principes du zéro déchet, au cœur de l’impressionnant Cirque de Salazie.
\n
L’extraction par technologie NaDES (Natural Deep Eutectic Solvent) et un procédé de fabrication sur mesure (nombre minimal d’étapes et durée limitée) permet d’obtenir un ingrédient éco-conçu associé à de hautes performances biologiques. L’ingrédient obtient ainsi un contenu d’origine naturelle de 99,85% selon la norme ISO 16128.
Différents modèles in vitro ont été combinés afin de démontrer la capacité de Solastemis™ à :
\n
– Protéger l’ADN et réparer les lésions induites par l’exposition aux UVA
\n
– Maintenir le potentiel d’auto-renouvellement des kératinocytes, également appelé “potentiel souche”
\n
– Fournir une photoprotection globale au niveau dermique et épidermique
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Une étude clinique en double aveugle (actif contre placebo) a confirmé l’efficacité de Solastemis™ à corriger différents symptômes du photo-vieillissement. L’actif réduit visiblement les rides de la patte d’oie et améliore le microrelief et la douceur de la peau. Le teint est embelli, plus éclatant et uniforme.
Protège la peau des lésions de l’ADN induites par les UVA
\n
Préserve les cellules souches épidermiques
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Offre un bouclier contre le photo-vieillissement
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Lisse la peau et réduit visiblement les rides
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Améliore l’homogénéité du teint
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Soins quotidiens de protection de la peau
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Traitements anti-âge avec et sans SPF
\n
Crèmes solaires visage ou corps en complément du SPF
\n
Produits de maquillage protecteur
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Though the laws of gravity are inescapable, the side effects they have on our skin don’t have to be.
\n
EleVastinTM is the targeted solution to gravity-induced skin sagging. The ingredient boosts key proteins involved in the synthesis and maintenance of functional elastic fibers. Doing so, it reinforces skin elasticity giving it the support needed to cope with this downward pressure.
\n
As a result, facial contours are redefined, deep and vertical wrinkles are reduced and a youthful appearance is restored.
EleVastinTM is a truly natural active ingredient, extracted from the leafy stems of Murraya koenigii, an ayurvedic and aromatic plant. The plant material is harvested in the preserved environnment of La Reunion island, on fertilizer-free plots.
\n
A rich pool of synergistic phytomolecules is obtained using a natural LTTM solvent (low transition temperature mixture) and gentle extraction process.
\n
The ingredient is COSMOS approved and reaches 100% natural origin content according to the norm ISO 16128.
Evaluated on 37 women with mature skin, EleVastinTM efficiently limits the impact of gravity on the lower part of the face, reduces skin sagging and deep vertical wrinkles.
\n
In 75% of cases, the volunteers look younger at the end of the study.
Facial care: anti-aging lines for mature skins, treatments dedicated to facial contours and V-shape, anti-gravity products, alternatives to liquid face lift
\n
Body care: remodeling / body sculptping products
\n
Sun care: products with anti-aging properties
\n
\n","actives":["wrinkles"],"actives_secondary":["natural","preservative_free","alcohol_free","bg_free"],"textures":"","textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23774"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/28"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=23774"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23774/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=23774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=23774"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=23774"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gatuline-rc-bio":{"id":1678,"date":"2017-04-23T12:21:25","date_gmt":"2017-04-23T10:21:25","guid":{"rendered":"/?page_id=1678"},"modified":"2021-03-22T18:17:06","modified_gmt":"2021-03-22T16:17:06","slug":"gatuline-rc-bio","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-actives/gatuline-rc-bio/","title":{"rendered":"Gatuline® RC Bio"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gatuline® RC Bio | Anti-aging moisturizing active | Gattefossé","_yoast_wpseo_metadesc":"Gatuline® RC Bio is a multipronged solution that stimulates cell oxygen consumption and increases skin hydration to minimize the appearance of wrinkles."},"categories":[6],"tags":[],"acf":{"component":"PageCosmeticProduct","product_codes":[{"code":"5742"}],"bandeau_image":{"id":13753,"alt":"","title":"Gatuline RC","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC.jpg","width":1144,"height":400,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Gatuline-RC-1038x400.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":400}},"image_product_finder":{"id":2674,"alt":"Happy young couple","title":"Gatuline RC Bio","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","width":244,"height":163,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","medium-width":244,"medium-height":163,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","medium_large-width":244,"medium_large-height":163,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","large-width":244,"large-height":163,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","post-thumbnail-width":244,"post-thumbnail-height":163,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/gatuline-rc-1.jpg","twentyfourteen-full-width-width":244,"twentyfourteen-full-width-height":163}},"title":"Gatuline® RC Bio","tagline":"Source of youth","description_product_finder":"","introduction":"
Renewed youth is the ultimate aim of anyone using an antiaging skin care product. Restoring natural skin conditions requires a multitargeted approach. Gatuline® RC Bio is a multipronged approach to skin aging. Sourced from beech tree buds, this ingredient stimulates cell oxygen consumption and increases skin hydration to minimize the appearance of wrinkles and aging for a healthier and younger appearance. Other grades available : Gatuline® RC / Gatuline® RP
Beech tree (Fagus sylvatica) buds harvested in Ardèche, France. F. sylvatica is a member of the Fagaceae family, which includes oak and chestnut trees. The height of this deciduous tree can exceed 35 meters. The beech tree embodies strength and elegance. It is called the “forever young” tree because it reaches maturity at 60 and can live up to 250 years.
\n
\n
Gatuline® RC BIO is made from buds of the majestic tree sourced in the Ardèche Mountains of France. Buds are chosen for their intense concentration of polyphenols, amino acids, and other primary metabolites to enhance the effects of this certified natural active.
Anti-aging solutions targeted for mature skins—anti-wrinkle, reparative, regenerative, moisturizing, skin radiance effects, etc.
\n
Moisturizers
\n
Eye contour treatments
\n
Complexion enhancers
\n
\n","actives":["energizing","moisturizing"],"actives_secondary":["organic","alcohol_free","bg_free"],"textures":"","textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1678"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=1678"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1678/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=1678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=1678"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=1678"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"excipients-for-efficient-skin-penetration":{"id":27004,"date":"2022-04-06T14:07:09","date_gmt":"2022-04-06T12:07:09","guid":{"rendered":"https://www.gattefosse.com/?page_id=27004"},"modified":"2022-04-13T09:32:05","modified_gmt":"2022-04-13T07:32:05","slug":"excipients-for-efficient-skin-penetration","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/excipients-for-efficient-skin-penetration/","title":{"rendered":"Excipients for efficient skin penetration"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Excipients for efficient skin penetration | Gattefossé","_yoast_wpseo_metadesc":"Discover our excipients for efficient skin penetration and our expertise in Franz cells diffusion to evaluate formulations and excipients efficiciency"},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Excipients for efficient skin penetration","content":"
\n
Three main steps govern drug diffusion from the formulation to the skin:
\n
\n
Solubility: the formulation must solubilize a sufficient amount of drug to reach the effective concentration at the target site
\n
Partition: the drug must partition out of the delivery vehicle into the upper layers of the SC
\n
Diffusion: the drug molecule diffuses through the SC mainly via the intercellular path
\n
\n
Discover Gattefossé range of excipients for solubilization and skin penetration:
Evaluating skin permeation with in vitro release test (IVRT) and in vitro permeation test (IVPT)
\n
In vitro methods exist to assess the drug penetration through the skin: IVRT uses synthetic membranes while IVPT uses animal or human skin.
\n
\n
\n
Rigorous protocols need to be developed to ensure the reliability of the results. Detailed information is given in our joint webinar with Teledyne Hanson provider of Franz cells. Gattefossé has developed standard protocols to evaluate skin penetration properties of our excipients in formulations. Access our publications for more details or contact us.
\n
\n","box_links":[{"link":"https://www.gattefosse.com/fr/__trashed-8","title":"On-demand webinar","external_link":"https://register.gotowebinar.com/recording/1077705433127806977","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Transcending-transdermal-delivery-690-375-px.jpg"}],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/fr/pharmaceuticals-special-content/publications-on-skin-drug-delivery/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/27004"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=27004"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/27004/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=27004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=27004"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=27004"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"foundation-master":{"id":967,"date":"2017-03-07T08:05:16","date_gmt":"2017-03-07T06:05:16","guid":{"rendered":"http://217.109.87.212/front/?page_id=967"},"modified":"2021-10-20T09:10:44","modified_gmt":"2021-10-20T07:10:44","slug":"foundation-master","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/foundation/foundation-master/","title":{"rendered":"Fondation Gattefossé"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Fondation | Une manière d'agir au-delà de la performance économique, au travers d'initiatives innovantes au service de l'intérêt général","_yoast_wpseo_metadesc":"La Fondation agit pour promouvoir l’utilisation scientifique et clinique des huiles essentielles comme approche thérapeutique complémentaire pour la santé."},"categories":[45],"tags":[],"acf":{"title":"Fondation Gattefossé","description":"En 2008, le groupe Gattefossé créait une fondation d’entreprise d’intérêt général. Cette fondation rend hommage à l’un des dirigeants de l’entreprise, René-Maurice Gattefossé, qui fut le pionnier de l’aromathérapie scientifique moderne au début du XXème siècle. Son usage des huiles essentielles pour des applications médicales l’amena à découvrir les vertus antiseptiques de la lavande. Il sut convaincre ensuite le corps médical des hôpitaux lyonnais d’utiliser cette huile essentielle dans des formulations servant à lutter contre certaines infections de l’époque. \r\n \r\nRené-Maurice est l’auteur de nombreuses publications et est à l'origine du néologisme « aromathérapie », devenu un mot courant après la publication de son ouvrage du même nom en 1937. \r\n \r\nAujourd’hui, sur les pas de son grand-père, Sophie Gattefossé-Moyrand, Présidente de la Fondation Gattefossé, lui rend hommage en contribuant à faire valoir l’intérêt des huiles essentielles comme thérapie complémentaire à la médecine allopathique. \r\n \r\nAu cœur de la médecine intégrative, la Fondation Gattefossé s’engage à développer l’aromathérapie clinique comme thérapie complémentaire au service du mieux-être des patients. \r\n \r\nLa Fondation agit en encourageant la recherche clinique, en favorisant la pratique en milieu hospitalier en France ainsi qu’en valorisant les praticiens de l’aromathérapie et leurs expériences cliniques. \r\n \r\nElle s’associe à l’écosystème de la santé intégrative et aux réseaux internationaux des associations professionnelles de l’aromathérapie clinique. 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science of high quality lipid excipient designing | Gattefossé","_yoast_wpseo_metadesc":"An in depth knowledge of oleochemistry enable us design high quality lipid excipients for the pharmaceutical industries."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Oleochemistry","introduction":"Gattefossé has designed and manufactured functional lipid excipients since 1950, developing strong capabilities in raw material qualification, synthesis reactions, process analytical technology, and quality control analysis.","":false,"content":[{"wysiwyg":"
Raw material qualification
\n
Our lipid excipients are manufactured using vegetable oils—including corn oil, apricot kernel oil, a wide array of plant-derived fatty acids—and alcohols—such as fatty alcohols, polyethylene glycol (PEG), propylene glycol (PG), and polyglycerol.
\n
Raw materials are subject to strict quality control before use to ensure they meet pharmacopeia standards and often stricter company specifications.
\n"},{"wysiwyg":"
Synthesis reactions
\n
Three reactions are commonly utilized in the manufacture of our excipients:
\n
\n
esterification, a reaction between acid and alcohol leading to ester and water
\n
\n
\n
\n
interesterification, a reaction between esters to produce new esters
\n
\n
\n
\n
transesterification, a reaction between ester and alcohol to produce a different ester and alcohol
\n
\n
\n
Depending on the raw materials used, these reactions enable the manufacture of solid, semisolid, or liquid excipients. The fatty-acid chain length and composition in terms of fatty alcohols and mono-, tri-, and diglycerides impact end-product physicochemical—hence functional—properties. Our oleochemists are thus able to develop pharmaceutical, nutraceutical, and cosmetic ingredients having targeted properties through the selection of raw materials and the design of synthesis reactions.
\n"},{"wysiwyg":"
Robust processes
\n
Since lipid excipients are made with natural plant-derived raw materials with intrinsic variability, process robustness is critical. Our oleochemists work with production teams to optimize synthesis processes and establish appropriate in-process controls that consistently deliver high product quality and batch-to-batch reproducibility.
\n
Their input helps fine-tune processes to control impurity levels that can impact excipient performance and stability.
\n
They are also working on processes that enable the reduction of waste materials, water consumption, and the use of catalysts.
\n"},{"wysiwyg":"
Oleochemistry R&D laboratory
\n
Many of our lipid excipients are complex multicomponent products. Our oleochemists develop and validate specialized analytical methods which serve four main purposes:
\n
\n
To elucidate the relationship between excipient composition and function and Critical Material Attributes
\n
To provide analytical support for the Quality by Design principles applied to excipients in pharmaceutical drug development
\n
To develop and analytically characterize new and custom excipients
\n
To contribute to Gattefossé customer technical support
\n
\n
Gattefossé has and continues to be a source of new validated analytical methods for lipid excipients, many of which have been incorporated into the European Pharmacopoeia.
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Hot melt extrusion is a continuous solvent-free technology with precise process control. Lipid excipients are mainly used as matrix formers for modified release, or as solubilizers for solubility/bioavailability enhancement, alone or in combination with polymers.
\n
\n
\n
Advantages of lipid excipients in hot melt extrusion:
\n
\n
low melt viscosity, resulting in low torque
\n
low extrusion temperatures (30–75 °C)
\n
low melting point and instant solidification, thereby avoiding downstream cooling
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
\n","box_links":[{"link":false,"title":"Tech Chat","external_link":"https://youtu.be/p8SAdfV6s2k","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/tech-chat8-322x216-1.jpg"}],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/missions-et-projets-k2e/pharmaceuticals-special-content/publications-on-hot-melt-extrusion/","external_link":""},{"text_link":"Watch our lab scale extruder demo","link":false,"external_link":"https://youtu.be/CT33vHgSVLs"}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"introduction":"","application_description":"","application_image":false,"oral_application_items":[],"topical_application_items":[],"rectal_application_items":[],"process_formulation_description":"","process_formulation_image":false,"oral_process_formulation_items":[],"topical_process_formulation_items":[],"rectal_process_formulation_items":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/pages/2924"}],"collection":[{"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/comments?post=2924"}],"version-history":[{"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/pages/2924/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/media?parent=2924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/categories?post=2924"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/missions-et-projets-k2e/wp-json/wp/v2/tags?post=2924"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"emulsions":{"id":2928,"date":"2017-04-25T09:32:39","date_gmt":"2017-04-25T09:32:39","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2928"},"modified":"2019-07-05T08:00:19","modified_gmt":"2019-07-05T06:00:19","slug":"emulsions","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-content/emulsions/","title":{"rendered":"Emulsions"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"How to formulate a stable emulsion | Gattefossé","_yoast_wpseo_metadesc":"Learn how to use lipid excipients to formulate stable emulsion systems and optimize the results of your formula with Gattefossé products."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Emulsions","content":"
Emulsions are, by definition, unstable systems and require a surfactant. To enable simple formulation of stable emulsion system, Gattefossé offers a range of self-emulsifying bases consisting of all-in-one excipients. Due to their specific compositions combining lipophilic and hydrophilic surfactants with texture agents, they provide stable emulsions whatever the type and concentration of oil.
\n
Emulsions are traditionally produced by separately preparing oily and aqueous phases and then mixing them together. Critical process parameters are temperature, blade type, mixing speed and duration, and cooling conditions. Emulsions with Gelot™ 64 are obtained in this way.
\n
\n
A one-pot process is an interesting alternative whereby all ingredients are mixed in a single step. This is achievable with a powerful emulsifier like Tefose® 63 at a minimum concentration of 12%.
\n
\n
A cold process might be necessary for heat-sensitive drugs. In such cases, the best emulsifier is Plurol® Diisostearique, which permits formulation at room temperature.
\n
\n
\n
Emulsification is obtained when mixing and heating yield enough energy to disperse the oil droplets in the aqueous phase, or vice versa. Thus, to obtain a stable emulsion, mixing conditions need to be carefully defined during development and scale-up.
\n
Our formulators have worked on scale-up—from lab- to pilot-scale production—with different formulations and equipment.
\n
Ask for our Dermacare brochure \n
\n
\n
\n","box_links":[{"link":false,"title":"Techchat","external_link":"https://youtu.be/xXM07_ewebE","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/tech-chat6-322x216.jpg"}],"useful_links":[{"text_link":"Excipients for optimizing texture","link":"https://www.gattefosse.com/pharmaceuticals-content/excipients-for-optimizing-texture-and-sensorial-experience/","external_link":""},{"text_link":"Range of excipients for topical drug 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butters."},"categories":[14],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageCosmeticProduct","product_codes":[{"code":"5898"}],"bandeau_image":{"id":21138,"alt":"","title":"1144x400px","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px.jpg","width":1144,"height":400,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/1144x400px-1038x400.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":400}},"image_product_finder":{"id":21139,"alt":"","title":"244x163px","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","width":244,"height":163,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","medium-width":244,"medium-height":163,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","medium_large-width":244,"medium_large-height":163,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","large-width":244,"large-height":163,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","post-thumbnail-width":244,"post-thumbnail-height":163,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/244x163px.jpg","twentyfourteen-full-width-width":244,"twentyfourteen-full-width-height":163}},"title":"Emulium® Dolcea MB","tagline":"Soft by nature","description_product_finder":"","introduction":"
Emulium® Dolcea MB is a PEG-free O/W emulsifier of 100% natural origin, easy to formulate and flexible which creates from fluid textures to thick butters.
\n
Emulium® Dolcea MB shows high compatibility with cosmetic ingredients and provides excellent stability alongside natural gelling agents.
\n
With immediate and long-lasting moisturizing power, this ingredient brings functionality and efficacy to a wide range of applications.
\n
Featuring a strong sensory signature, it brings extreme softness to cosmetic emulsions. COSMOS approved, Emulium® Dolcea MB can be used in organically certified, vegan and readily biodegradable formulations.
\n","use_level":"3-5%","naturalite":"Worldwide approval for cosmetic applications \r\nListed on IECIC (Inventory of Existing Cosmetic Ingredients in China) 2015 \r\nCOSMOS approved \r\nCertified RSPO Mass Balance \r\n","inci":"Cetearyl Alcohol (and) Glyceryl Stearate (and) \r\nJojoba Esters (and) Helianthus Annuus (Sunflower) Seed Wax (and) \r\nSodium Stearoyl Glutamate (and) Water (and) Polyglycerin-3","origin":"
Gattefossé pushed the limits of its patented wax butter technology to develop the most advanced and robust version of Gattefossé ingredients from wax butters, Emulium® Dolcea MB.
\n
Jojoba and sunflower waxes used in Emulium® Dolcea MB react with vegetable polyglycerol to create a 100% natural origin O/W emulsifier, which bring moisturizing benefits due to the vegetable waxes and true sensory identity.
Emulium® Dolcea MB can be added to the oil phase preferentially, or to the water phase if necessary. Robust, it is capable of emulsifying and stabilizing emulsions with up to 40% of oil phase. In the form of pellets, it is very easy to formulate, does not require high shear mixing and enables the creation of very fine emulsions (5-10 µm).
With Emulium® Dolcea MB, our most robust natural emulsifier, several processes can be used to answer different constraints. Watch this video to discover each of them and their benefits!
\n","img":{"id":21145,"alt":"","title":"Moisturizer","caption":"Female hand holding moisturizer in hand, horiztonal","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/Gattefosse_32104-e1614777378499.jpeg"},"video":""},{"content":"
Immediate and long-lasting moisturizing properties:
\n
\n
Significantly improves the moisturization of the skin compared to a PEG emulsifier
\n
The skin is moisturized up to 48 hours
\n
The skin moisturizing level is homogeneously improved throughout the face
\n
\n
\n","img":{"id":21144,"alt":"","title":"Close up of woman's face with freckles","caption":"Close up of woman's face with freckles","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/10/gettyimages-1023927920-170667a.jpg"},"video":""},{"content":"
Biodegradability:
\n
\n
The composition of Emulium® Dolcea MB has been carefully chosen to ensure excellent biodegradability
\n
97% of a cream containing Emulium® Dolcea MB has been biodegraded after only 28 days
\n
\n
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The most robust of Gattefossé natural emulsifiers range
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Easy to process in lab and production
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Intense and durable moisturization
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Brings extreme softness
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Creates readily biodegradable formulations
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From fluid textures to thick butters
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Skincare
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Color cosmetics
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Suncare
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Organically certified, vegan and readily biodegradable formulations
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Gattefossé has developed Emulium® Kappa MB to answer formulators’ need for a multifunctional PEG-free emulsifier of natural origin that yields stable emulsions; offers the added value of greater activity; and creates a unique sensorial identity.
\n
Oil-in-water emulsions based on Emulium® Kappa MB are very glossy and have a rich and luxurious feel. They are easy to apply, have a long play time, create a sensation of comfort, are softly textured (comparable to silicone elastomers), and exert a remarkable, lasting cushion effect—for baby-soft, replumed skin.
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Properties
\n
\n
allows the creation of voluptuous O/W cream
\n
possesses sensorial qualities similar to those of silicone elastomers
\n
truly active textures and natural moisturizing efficacy of hydrophilized wax complex and SSL (formation of a protective lipid film preventing transepidermal water loss; instrumental test)
Skin care—day or night creams, naturally moisturizing
\n
Anti-aging creams, “green” lines
\n
Supple creams, thick creams
\n
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Emulium® Mellifera MB is the first ever O/W emulsifier that auto-adapts to skin type and to climate, draping the skin in an invisible film that protects from environmental extremes.
\n
Created and formulated by teams across the world, Emulium® Mellifera MB creates light and smooth textures of great beauty and finesse. When the skin feels good, the results are visible. Moisturization, radiance, skin texture and smoothness, Emulium® Mellifera MB brings the guarantee of younger and healthier looking skin.
\n
Emulium® Mellifera MB brings a sensory solution to global consumer expectations, bringing delight upon application and visible efficacy.
Emulium® Mellifera MB is created from natural ingredients using green chemistry. Beeswax and Jojoba wax are reacted with vegetable polyglycerol. This transforms their texture to yield a soft and homogeneous butter with active properties.
Emulium® Mellifera MB contains functionalized plant waxes that leave a soft, barely perceptible film on the surface of the skin. This film plays a key role in helping the skin adapt to the environment.
\n
In nature, waxes are known to protect plants from dehydration and without them many species could not survive the seasons. Emulium® Mellifera MB brings this protecting role to the skin.
May be used on sensitive and hyperreactive skin (clinically tested)
\n
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\n
Fully flexible skin care textures
\n
Textures of Asian inspiration
\n
Color capture cosmetics
\n
Sun care—high SPF lotions and creams with a light feel
\n
Natural and organically certified formulations
\n
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Modified- or sustained-release matrices are designed to release a drug slowly over an extended period of time. Formulations must be robust to ensure drug release over time and avoid dose-dumping. Lipid-based matrices are water-insoluble and do not swell or erode when in contact with aqueous media. When used as sustained-release agents, they form an inert matrix from which the drug diffuses slowly.
\n
Advantages of Gattefossé’s modified-release agents:
\n
• Drug release is a function of diffusion, which enables simple product design and offers both straightforward modulation of drug release and high reproducibility. • Tablets are biopharmaceutically robust as the lipid matrix is not sensitive to physiological variations (e.g., pH, digestive processes, alcohol level). • Agents are suitable for a wide range of processing techniques, including direct compression, granulation, melt coating, hot melt extrusion, and capsule molding.
finely atomized lipid excipient powder of well-defined, reproducible composition and particle size
\n
used at proportion of 10%–40%, depending on drug solubility and diluent properties
\n
suitable for direct compression, granulation, and hot processes (i.e., hot melt coating, granulation, and extrusion)
\n
crystalline material with narrow melting range (∼70 °C) and rapid recrystallization, ideal for hot melt processes
\n
GRAS status and precedence of use with many APIs (FDA IID)
\n
\n
We can provide technical guidelines that offer useful tips on SR formulation development and numerous case studies with model drug molecules, e.g., bupropion HCl, levodopa, metformin HCl, metoprolol succinate, niacin, and theophylline.
finely atomized lipid excipient powder of well-defined, reproducible composition and particle size
\n
crystalline material with narrow melting range (∼55 °C) and rapid recrystallization, suitable for use in hot processes (i.e., hot melt coating, extrusion, and capsule molding)
\n
GRAS status and precedence of use with many APIs (FDA IID)
crystalline material with narrow melting range (∼60 °C) and rapid recrystallization, suitable for use in hot processes (i.e., hot melt coating, extrusion, and capsule molding)
\n
GRAS status and precedence of use with many APIs (FDA IID)
\n
\n
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The skin around the eyes is thinner than on any other part of our bodies, which makes it the most sensitive to change. Short nights, stress, and fatigue all contribute to puffiness and dark circles, affecting 80% of all women and as much as 50% of all men. Undereye bags and dark circles are the result of several disorders, including weak blood and lymphatic capillaries, poor drainage of interstitial fluids, skin sagging, and a reduction in microcirculation.
Cytobiol™ Lumin-Eye is an active blend based on the complementary benefits of three components: ash tree bark extract, vitamin B3 and organic silicon.
\n
Preservative free.
\n
\n
The high ash (Fraxinus excelsior) is a large tree commonly found in European forests. It draws its name from Latin fraxinus (“lightning”) because its height of up to 40 m attracts lightning.
\n
Its bark contains esculin and fraxin, two heterosides known to actively decrease the permeability of blood capillaries. These compounds give Cytobiol™ Lumin-Eye veinotonic and vasculoprotective properties. Moreover, fraxin and esculin have antioxidant activity that helps protect the blood capillaries while simultaneously resisting the breakdown of hemoglobin to reduce coloration under the eyes.
In vivo tests prove Cytobiol™ Lumin-Eye effectively reduces:
\n
\n
volume of undereye bags by up to 30%,
\n
color intensity of dark circles by 18%,
\n
area of dark circles by 15%.
\n
\n","img":{"id":3273,"alt":"Happy young woman smiling while lying on bed","title":"Happy young woman smiling while lying on bed","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/lumineue.jpg"},"video":""}],"claims":"
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Make better decisions earlier!
\n
\n
We developed this guideline to help formulate molecules with poor solubility and oral bioavailability into more drug-like compounds. The approaches described provide effective strategies to obtain the target dose, sufficient to allow the characterization and optimization of the pharmacokinetic, efficacy and safety profile.
\n
\n
Our aim is to help you work with our excipients to get the best results possibly reducing the risk of failure later on during development. Contact your local representative to get your copy of the guideline and technical support.
\n
\n
\n\n
\n
\n
What you will find in our guideline:
\n
\n\n
\n
Enabling strategies for efficacy, PK and safety evaluation
\n
\n
During lead optimization the scientist in preclinical development aims to maximize solubility and exposure of the test compound in animal models.
\n
In this chapter we highlight the appropriateness of our single excipients to enhance the bioavailability of compounds. We further provide ready-to-use platform formulations that were reported efficient in vivo.
\n
\n
\n
\n\n
\n
Safety and tolerability information
\n
\n
Understanding the excipient’s safety and tolerability profile in various species is crucial to prevent unexpected formulation-related effects.
\n
The compilation of our preclinical safety data helps you avoid long literature research and expensive evaluation of safe dosing volumes of Gattefosse excipients.How to correctly assess dosing volumes of excipient blends is also addressed in this chapter.
\n
\n
\n
\n\n
\n
Handling and dosing recommendations
\n
\n
Appropriate excipient handling and proper dosing to animals prevent misinterpretation of study results.
\n
We herein underpin the need for some of our excipients to be handled with care and dosed under specific precautions. Considering these handling procedures and dosing recommendations provide the best practices to assure reliable outcomes.
\n
\n
\n
\n\n
\n
Excipient summary tables
\n
\n
Functional excipients from Gattefosse are highly beneficial when used in enabled formulations for nonclinical evaluation and transfer to humans.
\n
Our excipients are thoroughly characterized and used in various medicines worldwide. Practical information is compiled at the end of this document enabling rapid retrieval of key information: physicochemical properties, regulatory status and precedence of use.
Hard fat suppository base comprising polyoxylglyceride esters to enhance drug solubility and bioavailability.
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Saturated polyglycolysed glycerides
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A non-ionic pure surfactant for lipid-based formulation to solubilize and increase oral bioavailability of poorly soluble API. Forms micellar solution in aqueous media.
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Polyoxyl-32 stearate (type I) NF
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Macrogol-32 stearate (type I) EP
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33GX5WQC0M
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PEG-32 STEARATE
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Polyoxylethylene stearates
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Selecting efficient pharmaceutical binder for developing robust extended release matrices of Compritol ® 888ATO prepared using wet granulation technique
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Part 1 Studying impact on granule & tablet properties
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Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
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K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
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This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
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K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
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This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
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K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
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This study evaluates impact of four pharmaceutical binders on dissolution profile of ER tablets of different API’s formulated using Compritol ® 888 ATO as sustained release agent
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Selecting efficient pharmaceutical binder for developing robust extended release matrices of Compritol ® 888ATO prepared using wet granulation technique
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Part 1 Studying impact on granule & tablet properties
\n
Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
\n
\n
\n
K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
\n
This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
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K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
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This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
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K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
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This study evaluates impact of four pharmaceutical binders on dissolution profile of ER tablets of different API’s formulated using Compritol ® 888 ATO as sustained release agent
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