A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol HP

Masumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph. – Gattefossé USA

In this study the authors developed stable anhydrous and hydrous creams containing 40% Transcutol^® HP, using predictive techniques to select appropriate excipients.

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TAM Technique for Identifying API-Lipid Excipient Compatibility Issues Upstream in the Development Process

Masumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph. – Gattefossé USA

In this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between API and excipients, using less time and resources than conventional techniques.

TAM technique is used routinely in Gattefossé North American Technical Center of Excellence to speed up formulation development.

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Gelucire 48/16^®: A Versatile Non-Ionic Solid Solubilizer for Tablets of Poorly Water-Soluble Drugs
Agnivesh Shrivastava, Ketkee Deshmukh, Nabil Farah, Sharda Gurram, Sunil Bambarkar

A solid dispersion of ticagrelor and Gelucire^® 48/16 is prepared to increase drug solubility. The solid dispersion is converted into tablets. The formulated tablets showed improved dissolution rate compared to the market reference.

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