Hot melt extrusion is a continuous solvent-free technology with precise process control. Lipid excipients are mainly used as matrix formers for modified release, or as solubilizers for solubility/bioavailability enhancement, alone or in combination with polymers.
Advantages of lipid excipients in hot melt extrusion:
Range of functional excipients for extrusion:
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.