Hot melt coating is a process in which molten lipid excipient is sprayed on to solid particles in a fluid bed coater. The lipid solidifies upon cooling and coats the particles with a thin, homogeneous film. This process can be used for taste masking, protection of sensitive APIs, or modification of drug release profiles.
Advantages of lipid excipients in hot melt coating:
Range of excipients for hot melt coating:
Gattefossé carried out an in vivo study in human subjects comparing the bioavailability of lipid-coated (Precirol® ATO 5) and uncoated acetaminophen. The results showed that the lipid coating has no impact on bioavailability.
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