Suppocire® and Ovucire™ are our well-established brands of semi-synthetic hard fat bases comprising fatty acid esters. Their physicochemical properties have been optimized to provide excellent drug delivery for both solid and liquid active pharmaceutical ingredients (APIs), across the range of water solubility.
We offer a wide range of bases for suppositories and pessaries. Here you will find a selection of the most versatile grades. Our bases and formulation expertise enable you to:
These multipurpose vehicles span a range of melting points and hydroxyl values and are suitable for a wide spectrum of APIs. They are ideal for straightforward formulations using manual, semi-automated, or fully automated equipment.
|Suppocire® Grade||Suppocire® Main Characteristics|
|Suppocire® AM||Low melting point|
|Suppocire® BM||Intermediate melting point|
|Suppocire® NAI 25 A||Low melting point; long-chain glycerides enable production of hard suppository units|
Some APIs are more difficult to formulate due to properties such as hydrophilicity, sensitivity to oxidation, or high drug load. They require special bases like the following:
|Drug Characteristics||Suppocire® Grade|
|Hydrophilic||Suppocire® AS 2|
|Suppocire® NAS 50|
|Suppocire® BS 2 X|
|Suppocire® CS 2 X|
|Sensitive to oxidation||Suppocire® NA 15|
|Low bioavailability||Suppocire® AP|
|High drug load||Suppocire® AML|
|Ovucire™ Grade||Ovucire™ Main Characteristics|
|Ovucire™ 3460||Good mechanical resistance and enhanced spreadability within the vaginal cavity|
|Ovucire™ WL 3264||With additive to enhance API dispersion and wettability|
Contact Gattefossé to obtain reference formulations with APIs such as acetaminophen, clotrimazole, diclofenac sodium, econazole nitrate, hydrocortisone acetate, ketoprofen, lidocaine hydrochloride, mesalamine, metronidazole, miconazole nitrate, nystatin, papaverine, phloroglucinol, piroxicam, probiotics, procaine, progesterone, and ruscogenin in association with trimebutine.