Gattefossé publications
Find below the list of all publications (articles and posters) of Gattefossé scientists.Posters are available to download after log-in.
2022
- Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water-Soluble Drugs Formulated using Compritol 888 ATO and Methocel as Release Retarding Agents
- A Systematic Approach to Developing Lipid-Based Drug Delivery Systems with Fenofibrate as Model Drug
- Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
- Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
- Gelucire® 48/16: a safe wetting agent for tablet. A case study with fenofibrate
- Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers
- Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets
- Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of Delta‑9‑Tetrahydrocannabinol
- Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation
- Oral Drug Delivery for Modified Release Formulations
- Critical Criteria for Assessing the Permeation Performance of Topial Formulas on Animal skin: Standardization of IVPT Protocols
- Cannabinoid molecules and their love of lipid excipients
2021
- Carving out a Niche in Parmaceutical Drug Delivery
- Lipid-based nanocarriers for oral delivery of peptides
- Solid lipid nanocarriers to increase oral bioavailability of the peptide Leuprolide
- A 3D-Printed Polymer-Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
- GELUCIRE® 4414 for type IV lipid based formulations and their in vitro in vivo performance evaluation
- Solubility and Stability of Delta-9-Tetrahydrocannabinol in Lipid Excipients
- Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 1 Studying impact on granule & tablet properties
- Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
- FORMULATION FORUM – A Quick Approach for Evaluation of Drug-Excipient Compatibility: Case of Acetylsalicylic Acid
- Solid lipid nanocarriers to increase oral bioavailability of the peptide Leuprolide
- Lipid excipients to unlock oral bioavailability issues
2019
- A proof-of-concept for developing oral lipidized peptide nanostructured lipid carrier formulations
- Gelucire 48/16® for Type-IV Lipid Based Formulations and Their In Vitro In Vivo Performance Evaluation
- In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal tract
- Lipid excipients in pharmaceutical technologies
- A snapshot of lipid excipients for topical formulations
- Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer
- Synergising excipients to boost skin delivery. A case study with lidocaine hydrochloride
- Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
- Understanding The Role Of In Vitro And In Vivo Evaluation Techniques In Determining the Performance of Lipid-Based Formulations
- In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions For Oral Peptide Delivery
- Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
- In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
- A Proof of Concept for 3D Printing of Solid Lipid Based formulations of Poorly Water Soluble Drugs to Control Formulation Dispersion Kinetics
- Synergising excipients to boost skin delivery
- Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
- Colloidal aspects of dispersion and digestion of self dispersing lipid based formulations for poorly water soluble drugs
- Lipids and polymers in pharmaceutical technology: Lifelong companions
- An efficient method to determine the Hydrophile-Lipophile Balanceof surfactants using the phase inversion temperature deviation of CiEj/n-octane/water emulsions
2018
- Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
- An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
- Gelucire 48/16®: A Versatile Non-Ionic Solid Solubilizer for Tablets of Poorly Water-Soluble Drugs
- High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking.
- The Gelucire® family
- Labrasol® is an efficacious non-damaging intestinal permeation enhancer in isolated rat intestinal mucosae
- Bioavailable Curcumin – A Type 4 Lipid Based Drug Delivery System Using Gelucire®48/16 As Solid Solubilizer
- A Novel Approach To Prepare Solid Self-microemulsifying Drug Delivery System Without A Solid-phase Carrier Using 3D Printing
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Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
- High shear coating: a versatile coating process
- Improving patient experience with sensorial topical dosage forms
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Lipid-based nanosuspensions for oral delivery of peptides, a critical review
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Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
2017
- A Systematic Approach to Lipid-Based Formulation Development for a Poorly Soluble API, Fenofibrate
- QbD – How particle size and glyceride composition affect the performance of sustained-release tablets with Compritol 888 ATO
- Taste-masked drugs for pediatric medicines through lipid coating
- Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug
- Gelucire 48/16®: A Non-Ionic Solid Surfactant for Solubility Enhancement of Poorly Soluble Drugs
- LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
- Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation
- Efficient taste masking through high shear coating with lipid excipients
- Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
- Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems
- Amélioration de la biodisponibilité des substances actives via la formulation galénique [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies]
- Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
- Inclusion of digestible surfactants in solid SMEDDS formulation removes lag time and influences the formation of structured particles during digestion
2016
- Gelucire® 48/16: a solid surfactant for tablets
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Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
- Converting simple microemulsion into attractive foam for topical pain treatment. A case study with lidocaine base
- Converting light emulsion into a creamy foam for psoriasis treatment. A case study with betamethasone dipropionate
- Experience foam for topical drug delivery
- Maisine® CC, a unique pharmaceutical oil for solubility and oral bioavailability enhancement
- In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates
- Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection
- Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API
- Novel Pegylated lipid excipients: Role in augmenting dissolution of a poorly soluble drug.
- Solidification of liquid self-emulsifying lipid formulations by loading on solid mesoporous carriers
- Attractive emollient foams for pain treatments
- Pharmaceutical foams with optimized microemulsion and propellant-free pump
2015
- Influence of Formulation Factors and Compression Force on Release Profile of Sustained Release Metoprolol Tablets using Compritol® 888 ATO as Lipid Excipient
- Efficient skin delivery: no compromise with Transcutol®
- Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity
- In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
- Reaching milestones in lipid-based formulations: from effective prediction to successful development
- New insights into the stability of SR lipid matrix tablets
- Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis
- Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
- Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.
- Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate.
- Evaluating the lubricant capacity of Compritol® HD 5 ATO, a water dispersible pharmaceutical lubricant.
- Biorelevant media resistant co-culture model mimicking permeability of human intestine.
- Exploring the possible relationship between the drug release of Compritol®-containing tablets and its polymorph forms using micro X-ray diffraction.
2014
- Solid Lipid Excipients : Born to be extruded !
- Formulation of a self-emulsifying lipid formulation of curcumin
- Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations
- Designing aqueous gels with lipophilic solubilizers for dermal application
- Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?
- Compritol® 888 ATO vs Precirol® ATO 5 in hot melt extrusion: investigation of operating window limits
- Ethanol resistant extended release matrix tablets with Compritol® 888 ATO
- Colour coating of Compritol® 888 ATO matrix tablets: a feasability study
- Effect of tablet structure on controlled release from supersaturating solid dispersions containing glyceryl behenate
- Estimating in vivo drug release from a new theophylline Compritol® 888 ATO matrix formulation using appropriate biorelevant test methods
- Streamlining the design of sustained release matrix tablets using mathematical modeling for drug release optimization
- The effect of process on drug release of Compritol® 888 sustained release tablets: direct compression, wet granulation and hot melt extrusion
- Solid Lipid Excipients as Matrix Agents for Sustained Drug Delivery
- Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of representative formulations by gastric lipase.
- Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels.
- Rectal route in the 21st century to treat children.
- Smart strategies for sustained release tablets: Compritol® 888 ATO
- Impact of diluent type on Compritol® 888 ATO sustained release tablets
- Hot melt extrusion with Compritol® 888 ATO: determination of processing boundaries
- Measuring solubility performance of skin penetration enhancers for three anti-inflammatory drugs
- A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by a new seeding procedure.
- Polyoxylglycerides and glycerides: effect of manufacture on API stability, excipient functionality and processing.
- In silico simulation of niacin release from lipid tablets: theoretical predictions and independent experiments
- Mechanisms controlling theophylline release from ethanol-resistant coated pellets
2013
- Formulation et fabrication des suppositoires [Formulating and manufacturing suppositories]
- Influence of intestinal biorelevant fluids on a novel co-culture cell model able to mimic varaible permeabilities of the human intestine
- Self formulation protocol: part I – solubility determination in liquid and solid excipients
- Self formulation protocol: part II – excipient selection, diagram design and selection of prototype formulations
- Self formulation protocol: part III – impact of lipolysis on prototype formulations
- In vitro lipolysis study of nanoparticulate delivery systems: solid lipid nanoparticles and nanostructured lipid carriers
- High drug load lipid matrix tablets prepared by wet granulation: part I – formulation parameters
- High drug load lipid matrix tablets prepared by wet granulation: part II – process parameters
- Percolation threshold of Compritol® 888 in matrix tablets: assessing the minimum concentration to create an infinite lipid network
- Sustained release levodopa mini-tablets containing Compritol® 888: a viable approach for special patient populations
- Hot melt coating with lipid excipients
- Functional characterization of powders consisting of mixture of glyceryl behenate and a non-ionic surfactant applied by hot-melt coating: lubricant performance
- Ethanol-resistant ethylcellulose/guar gum coatings – importance of formulation parameters
- In vitro digestion of the self-emulsifying lipid excipient Labrasol® by gastro-intestinal lipases and influence of its colloidal structure on lipolysis rate
- Ethanol-resistant polymeric film coatings for controlled drug delivery
- Compritol® 888 ATO a lipid excipient for sustained release of highly water soluble actives: formulation, scale-up and IVIVC study
2012
- Understanding the lipid-digestion process in the GI tract before designing lipid-based drug-delivery systems
- Lipid matrix by hot melt extrusion: a practical industrial solution for solid dispersion
- Synergy effect of two glycerides to increase stability and ethanol resistance of sustained release matrix tablets
- Compritol® 888 ATO lipid matrices for sustained release processed by hot melt extrusion
- Development of a novel co-culture cell model able to mimic variable permeabilities of the human intestine and tolerate biorelevant media
- Characterization of a new self-emulsifying excipient to expand formulation options for poorly soluble drugs: Gelucire® 48/16
- Sustained-release of diclofenac sodium from wet granulated Compritol® 888 ATO matrix tablets
- Development and evaluation of sustained release Compritol® 888 ATO matrix mini-tablets
2011
- Performance of a Compritol® 888 ATO lipid matrix tablet to deliver sustained release of diclofenac sodium
- Preparation of hot melt extruded supersaturating solid dispersions containing glyceryl behenate: effects of processability, supersaturation and rate of release
- Formulation effects on drug release from sustained-release Compritol® 888 ATO tablets and mini-tablets
- Compartmentalization of the human stratum corneum by persistent tight junction-like structures
2010
- Diluent effects on drug release from sustained release Compritol® 888 ATO tablets
- Gastro-intestinal lipolysis of lipid-based excipients intended for oral drug delivery of poorly water soluble drugs
- Specific assay of carboxyl ester hydrolase using PEG esters as substrate
- An investigation into the mechnism of dissolution rate enhancement of poorly water soluble drugs from spray chilled Gelucire® 50/13 microspheres
2009
- Lauroyl polyoxylglycerides, functionalized coconut oil, enhancing the bioavailability of poorly soluble active substances
- Vaginal cream formulation for the prevention of HIV infection for women in developing countries
- In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self-emulsifying excipients Labrasol® and Gelucire® 44/14
- Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity
2008
- Guidelines to formulate OTC drugs in topical emulsions with improved sensorial properties
- Effect of Labrafil M2125CS and its digestion products on viability of Caco-2 cells
- Influence of the particle size of aqueous dispersions of Labrasol® on the activity of digestive lipases
- Lipolysis of the semi-solid self-emulsifying excipient Gelucire® 44/14 by digestive lipases
- Approaches for the development of solid and semi-solid lipid-based formulationns
2007
- In vitro lipolysis of the self-emulsifying excipient, Labrasol®
- Comparative study on digestive lipase activities on the self-emulsifying excipient Labrasol®, medium chain glycerides and PEG esters
2006
- Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy
- Pharmaceutical surfactants in biorelevant media: impact on lipolysis and solubility of a poorly soluble compound, danazol
- In vitro evaluation of pharmaceutical surfactants fate during lipolysis and its effects on solubilization of a poorly water soluble compound, danazol
- Solubilization of a poorly soluble model drug during in vitro lipolysis of macrogol glyceride surfactants at fed and fasted state conditions
- The fate of some surfactants during in vitro lipolysis and the effect on solubilization of a poorly soluble model compound
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Interest of carriers for the development of solid self-emulsifying drug delivery systems
2005
- Influence of poloxamers on the dissolution performance and stability of controlled-release formulations containing Precirol® ATO 5
- Interest of multifunctional lipid excipients: case of Gelucire® 44/14
- Modification of the drug release of ibuprofen by hot melt coating with mixes of Compritol® 888 ATO and non ionic surfactant
- Development of tablets with self-emulsifying drug delivery systems (SMEDDS)
- Poloxamers influence the dissolution and stability of lipid matrices of Precirol® ATO 5
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Bibliography on Gattefossé’s products. 2004-2005 review.
- Systèmes auto-emulsionnables et émulsions sèches [Self emulsifying drug delivery systems]
2004
- Structural and thermal characterization of lipidic excipients and carriers by X-ray diffraction coupled to differential microcalorimetry
- Structural and thermal characterization of mono and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry
2003
- Enhanced bioavailability of simvastatin in a self-emulsifying drug delivery system (SMEDDS)
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Development of immediate release pellets of poorly soluble compounds using Gelucire® 44/14
- Comparative study of the lubricant performance of Compritol® HD5 ATO and Compritol® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity
