Suppocire® bases comprise chemically stable fatty acid esters with a narrow melting range. Their physicochemical properties provide numerous formulation and manufacturing advantages, including optimized solidification properties and straightforward scale-up with low, medium, and high throughput manufacturing equipment. Careful selection of the right Suppocire® base ensures optimal physicochemical stability and drug delivery properties, as defined by European Pharmacopeia requirements. In addition, Suppocire® formulations are usually simple binary mixtures of the API dissolved or dispersed in the suppository base. They do not require additional excipients to enhance performance, quality, or stability. Step 1: Suppocire® melting Suppocire® pellets are heated at 20 °C above the melting point—indicated in the product technical data sheet—while stirring to ensure the base is thoroughly melted and perfectly homogenized. Step 2: API addition The API is added at a temperature above the recrystallization temperature of the base, generally 30–45 °C. Stirring continues during addition of the API to ensure homogeneity. Step 3: Blister filling The melted, homogenized mixture is poured into the mold at a specific temperature, as determined by a thermorheogram. A thermorheogram plots viscosity versus temperature and allows you to find the optimal mold or blister filling temperature during production. Since viscosity is a function of the specific formulation ingredients, a thermorheogram is necessary for each formulation. Gattefossé has a thermorheogram for each grade of product in the product page section.