Solid lipid excipients – matrix agents for sustained drug delivery.
Yvonne Rosiaux, Vincent Jannin, Sophie Hughes, Delphine Marchaud Journal of Controlled Release Volume 188, 28 August 2014, Pages 18–30
This review article focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions and (iv) long-term stability. Understanding the functionality of these versatile excipients in formulation is elementary for the development of highly robust lipid-based sustained release medicines
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