Comparative study of the lubricant performance of Compritol®888 ATO either used by blending or by hot melt coating
V Jannin, V Bérard, A N’Diaye, C Andrès, Y Pourcelot
International Journal of Pharmaceutics. Volume 262, Issues 1–2, 27 August 2003, Pages 39–45
In this study, the lubricant performance of Compritol 888 ATO is assessed in a classical blending process or by hot melt coating. The results suggest that the hot melt coating process induces an homogeneous repartition of the lubricant on the lactose surface,
contrary to classical blending procedure. Thus, lubrication by hot melt coating seems to be a very efficient procedure. It could be used specifically for large surface area particulate systems producing a lot of friction.
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