During lead optimization the scientist in preclinical development aims to maximize solubility and exposure of the test compound in animal models.
In this chapter we highlight the appropriateness of our single excipients to enhance the bioavailability of compounds. We further provide ready-to-use platform formulations that were reported efficient in vivo.
Understanding the excipient’s safety and tolerability profile in various species is crucial to prevent unexpected formulation-related effects.
The compilation of our preclinical safety data helps you avoid long literature research and expensive evaluation of safe dosing volumes of Gattefosse excipients.How to correctly assess dosing volumes of excipient blends is also addressed in this chapter.
Appropriate excipient handling and proper dosing to animals prevent misinterpretation of study results.
We herein underpin the need for some of our excipients to be handled with care and dosed under specific precautions. Considering these handling procedures and dosing recommendations provide the best practices to assure reliable outcomes.
Functional excipients from Gattefosse are highly beneficial when used in enabled formulations for nonclinical evaluation and transfer to humans.
Our excipients are thoroughly characterized and used in various medicines worldwide. Practical information is compiled at the end of this document enabling rapid retrieval of key information: physicochemical properties, regulatory status and precedence of use.