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The feasibility of preparing solid SEDDS using solid (Gelucire® 48/16) and semi-solid (Gelucire® 44/14) lipid excipients with a 3D printer is assessed using two model drugs, i.e. cinnarizine and fenofibrate.
Keywords: 3D printing, Gelucire® 44/14, Gelucire® 48/16, fenofibrate, cinnarizine
The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
Keywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load
The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
Keywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO
In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
Keywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH