To cross the skin barrier, a drug needs to be in a solubilized state. Gattefossé offers a full range of solubilizers that meet the needs of topical drug delivery, from aqueous solvents to oily vehicles. We have undertaken many studies investigating drug solubility in various excipients.

Range of solubilizers
Transcutol® P:
- exceptional solvent capacity
- safe; nonirritant
- drug depot effect reported with certain lipophilic APIs
- used in numerous topical dosage forms (e.g., creams, emulgels, foams, gels, and ointments)
- precedence of use (FDA IID) in topical formulations worldwide
Labrasol®:
- O/W surfactant
- excellent solubilizing capacity
- used in gel, foam, or microemulsion
- precedence of use
Lauroglycol™ FCC:
- W/O surfactant/cosurfactant
- propylene glycol esters with medium-chain fatty acid (C12)
- good solubilizing capacity
- used in emulgel or microemulsion
Capryol® PGMC:
- W/O surfactant/cosurfactant
- propylene glycol esters with short-chain fatty acid (C8–C10)
- good solubilizing capacity
- used in emulgel or microemulsion