Excipients for Emulsification

To enable straightforward formulation of stable emulsion systems, Gattefossé offers a range of all-in-one emulsifiers. Due to their specific composition combining lipophilic and hydrophilic surfactants with a texture agent, they provide stable emulsions whatever the type and concentration of oil.  

Advantages of lipid excipients:

• self-emulsifying bases for all phases (glycerin, PEG, alcohol, propylene glycol, mineral oil, MCT)
• excellent compatibility with APIs (including salt forms), preservatives, and gelling agents
• yield creams with high heat stability over a wide pH range
• versatile—for formulation of sprays, lotions, creams, and balms with improved texture and sensorial properties
• non irritant
• odor- and color-free

Range of emulsifiers

Tefose^® 63:

• versatile: can be used with a wide range of drugs
• range of viscosity, including fluid, foam, or rich cream
• use at 5%–20% (w/w)
• worldwide precedence of use
• outstanding mucosal tolerance for antifungal treatments
• one-pot manufacturing process feasible

Gelot™ 64:

• ideal for difficult-to formulate APIs (e.g., alcohol extracts, acidic drugs, and essential oils)
• forms rich creams and balms over a wide pH range
• use at 2%–12% (w/w)
• can emulsify anhydrous phase (PEG, glycerin)
• suitable for anti-acne drugs (tretinoin, azelaic acid)
• precedence of use

Plurol^® Diisostearique:

• liquid excipient ideal for heat-sensitive APIs when used in cold emulsification process
• PEG-free emulsifier
• nonirritant; suitable for sensitive skin
• forms rich creams when used at 3%–6% (w/w)
• W/O emulsification: up to 85% of aqueous phase

Tefose^® 1500:

• versatile: can be used with a wide range of drugs
• recommended for sprays and lotions
• use at 5%-10% (w/w)
• precedence of use