Three main steps govern drug diffusion from the formulation to the skin:
Discover Gattefossé range of excipients for solubilization and skin penetration:
In vitro methods exist to assess the drug penetration through the skin: IVRT uses synthetic membranes while IVPT uses animal or human skin.
Rigorous protocols need to be developed to ensure the reliability of the results. Detailed information is given in our joint webinar with Teledyne Hanson provider of Franz cells. Gattefossé has developed standard protocols to evaluate skin penetration properties of our excipients in formulations. Access our publications for more details or contact us.
Rigorous protocols need to be developed to ensure the reliability of the results. Detailed information is given in our joint webinar with Teledyne Hanson provider of Franz cells. Gattefossé has developed standard protocols to evaluate skin penetration properties of our excipients in formulations. Access our publications for more details or contact us.
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\n\n
Advantages of lipid excipients in hot melt extrusion:
\nRange of functional excipients for extrusion:
\n\n
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
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Three main steps govern drug diffusion from the formulation to the skin:
\nDiscover Gattefossé range of excipients for solubilization and skin penetration:
\nIn vitro methods exist to assess the drug penetration through the skin: IVRT uses synthetic membranes while IVPT uses animal or human skin.
\nRigorous protocols need to be developed to ensure the reliability of the results. Detailed information is given in our joint webinar with Teledyne Hanson provider of Franz cells. Gattefossé has developed standard protocols to evaluate skin penetration properties of our excipients in formulations. Access our publications for more details or contact us.
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