“This work deals with fully green ternary mixtures composed of three low cost, bio-sourced and safe molecules, namely Fructose (F), Glycerol (G), and Water (W), able to interact to each other by H-bonds.” Read more.
An optimized LBF enables solubilization of the entire therapeutic dose and maintains the drug in solubilized state throughout the digestion process.
\nTo speed up LBF development, we have produced tools to guide you at each stage of development:
\n1 – methods for saturation solubility screening
\n2 – database of solubility of drugs in common pharmaceutical excipients
\n3 – methods for miscibility and dispersability testing
\n4 – miscibility table
\n5 – in vitro lipolysis procedure
\n6 – guideline for preclinical studies
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\nE. Dauphin-Chanard ; A. Forest ; C. Deleglise ; D. Hoste ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
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\nMasumi Dave ; Jasmine Musakhanian ; Jason LePree and Rollie Fuller
\nGattefossé USA – Paramus – USA
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\nPoster PBP 2022
\nTo assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.
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\nEur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12.
\nIn this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.
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\nPoster Skin Forum 2019
\nIn this study the authors showed that combining an efficient solubilizer and penetration enhancer achieves a synergic effect which enhances the passive diffusion of LID HCl through the Strat-M membrane in this Franz cell model.
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\nOn Drug Delivery – March 2019
\nThis article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
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\nDrug Dev Ind Pharm. 2018 Oct;44(10):1642-1649. doi: 10.1080/03639045.2018.1483391. Epub 2018 Jul 2.
\nA patch for transdermal delivery of daphnetin was developped using Transcutol® P as permeation enhancer.
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\nAccess our publications on Transcutol®
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\n
According to recent articles, the way you perceive aging can actually influence how you age. “Positive and negative attitudes can affect your health behaviorally, psychologically, and even biologically. Being ‘pro-aging’, or satisfied with your own aging, can make you adopt healthier behaviors, feel in control of how you age, and even heighten your immune system.”1
\n\n
\n
We are beginning to see this shift towards pro-aging make its way into beauty and cosmetics. Baby boomers, as they age, are realizing that aging can’t be fought forever and are instead embracing the changes that come with time. And cosmetics companies are moving with the mindset of their customers.
\n\n
\n
Pro-aging doesn’t mean a rejection of cosmetics, but rather a more targeted selection towards products designed to enhance the appearance at any age, instead of hiding and fighting every symptom of aging. The philosophy behind pro-aging is to remove all “anti” claims and replace them with more positive imagery. “Pro-age products are more about nourishing and moisturizing the skin, enhancing features rather than trying to fill them in or mask them.”2
\n\n
\n
Gattefossé offers ingredients that meet the demands of the pro-aging trend.
\n\n
Download the formula sheets in the “Related documents” box in the right column.
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Their physicochemical properties have been optimized to provide excellent drug delivery for both solid and liquid active pharmaceutical ingredients (APIs), across the range of water solubility.
\n
\n
We offer a wide range of bases for suppositories and pessaries. Here you will find a selection of the most versatile grades. Our bases and formulation expertise enable you to:
\nThese multipurpose vehicles span a range of melting points and hydroxyl values and are suitable for a wide spectrum of APIs. They are ideal for straightforward formulations using manual, semi-automated, or fully automated equipment.
\nSuppocire® Grade | \nSuppocire® Main Characteristics | \n
Suppocire® AM | \nLow melting point | \n
Suppocire® NAI 25 A | \nLow melting point; long-chain glycerides enable production of hard suppository units | \n
Some APIs are more difficult to formulate due to properties such as hydrophilicity, sensitivity to oxidation, or high drug load. They require special bases like the following:
\nDrug Characteristics | \nSuppocire® Grade | \n
Liposoluble | \nSuppocire® CM | \n
Hydrophilic | \nSuppocire® NAS 50 | \n
Glycerin | \nSuppocire® AGP | \n
Sensitive to oxidation | \nSuppocire® NA 15 | \n
Ovucire™ Grade | \nOvucire™ Main Characteristics | \n
Ovucire™ 3460 | \nGood mechanical resistance and enhanced spreadability within the vaginal cavity | \n
Ovucire™ WL 3264 | \nWith additive to enhance API dispersion and wettability | \n
\n
Contact Gattefossé to obtain reference formulations with APIs such as acetaminophen, clotrimazole, diclofenac sodium, econazole nitrate, hydrocortisone acetate, ketoprofen, lidocaine hydrochloride, mesalamine, metronidazole, miconazole nitrate, nystatin, papaverine, phloroglucinol, piroxicam, probiotics, procaine, progesterone, and ruscogenin in association with trimebutine.
An oily vehicle and solubilizer of lipophilic APIs for oral and topical lipid-based formulations (LBFs).
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“A eutectic mixture is defined as a mixture of two or more components which usually do not interact to form a new chemical compound but which, at certain ratios, inhibit the crystallization process of one another resulting in a system having a lower melting point than either of the components.”1
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Our newest active, Gatuline® Link n Lift takes advantage of NaDES technology to bring improvement to the eye contour – visibly reducing difficult to erase under-eye and tear-trough wrinkles.
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\n\n
\n
Gattefossé has obtained rights to develop and commercialize cosmetic active ingredients obtained using the highly innovative NaDES technology.
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\n\n\n
Labrasol® is a liquid oil-in-water (O/W) surfactant (HLB=12) with excellent solubilizing capacity. It is often used in combination with a cosurfactant such as Plurol® Oleique CC 497 (HLB=3).
\nLabrafac™ Lipophile WL 1349 is an oily vehicle with emollient properties.
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E Dauphin-Chanard, C André and D Marchaud
\nPoster – AAPS 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster AAPS 2016
\n\n\n"},{"wysiwyg":"
November 2016
\nPharmaceutical foams are becoming more popular probably due to more topical medicines being switched to OTC and the need to innovate and differentiate ‘brands’ and an increasing awareness of the importance of formulating to deliver sensorial benefits and positive impact on patient experience and adherence. Gattefossé, as a leading provider of excipients for the pharmaceutical industry, manufactures solubilizers and texturizers for skin drug delivery. In this white paper we give formulation tips for propellant and propellant-free foams with guidelines on how to formulate and select excipients and case studies with model drugs.
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster Skin Forum, June 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André, D Hoste and D Marchaud
\nPoster PBP, April 2016
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\nWe thank you for your interest in our company. In this section, you can find the more recent press releases, pictures and videos published by Gattefossé and its Foundation.
\nDo you have any questions? We would be happy to answer your media inquiries. | \nClaudine Blondet press@gattefosse.com | \n
\n
\n\n
Gattefossé develops, manufactures and sells specialty ingredients for the personal care and pharmaceutical industries and offers a strong expertise in formulation for both of these activities.
\nGattefossé markets its products in more than 60 countries through 12 affiliated companies and a network of agents and distributors who provide technical and marketing support. Innovation, ethics, quality and long-term stability are the company key-drivers since the beginning.
\nGattefossé was founded in Lyon, France in 1880 by Mr. Louis Gattefossé to whom building strong relationship with customers was a priority. The company remains a family-run, independent business, and now employs more than 300 people worldwide.
\n\n\n
Click on the pictures to download HD portraits of our Chairman, Jacques Moyrand and our CEO, Eduardo De Purgly.
\nCopyright Véronique Védrenne
\n\n\n
April 15th, 2019 – GOLD rating for Gattefossé on EcoVadis
\n
April 3rd, 2019 – Gattefossé receives the Gold Innovation award for Emulium® Illustro
\n
March 9th, 2019 – Definicire™ receives PCHi Fountain Awards 2019 in China
\n
February 19th, 2019 – Gattefossé launches its new W/O emulsifier at in-cosmetics global
\n
December 17th, 2018 – COSMET’AGORA 2019, a new edition for Gattefossé’s tool INSPIRATION
\n
October 23, 2018 – Gattefossé North America announces the recipient of the 2018 Award for Excellence
\n
September 19th, 2018 – Gattefossé launches its first hair care
\n ingredient at in-cosmetics Latin America
\n
July 10th 2018 – Gattefossé renews its ISO 9001 certification and achieves the 2015 version
\n
June 5th 2018 – Official launch of ERI 360° Label
\n\n
\n
April 10th 2018 – Meet the #ConnectedGenerations at in-cosmetics global 2018
\n
March 29th 2018 – EnergiNius™: Gattefossé new launch at in-cosmetics Amsterdam 2018
\n
February 20th 2018 – Gattefossé Asia Pacific achieves ISO9001: 2015 certification
\n
January 25th 2018 – Gattefossé launches INSPIRATION tool
\n
November 10th 2017 – Gattefossé North America announces the recipient of the 2017 Award for Excellence
\n
November 6th 2017 – SIO-ADM, Gattefossé partner to bring USP/NF grade highly refined oils to North America
\n
October 18th 2017 – GATTEFOSSÉ and CYTOO join forces to investigate the biological effects of screen-emitted light on skin
\n
September 20th 2017 – The Gattefossé foundation supports two Health establishments
\n
July 28th 2017- Gattefossé Canada and Connect Chemicals announce distribution agreement
\n
April 26th 2017- Inauguration of our North America Technical Center of Excellence
Contact us to receive the Press Dossier
\n\n\n
Download the HD picture HD picture
\n
March 29th 2017 – Show true emotions at in-cosmetics London: two ingredients targeting the eye and lip contours
\n
March 21th 2017 – Gattefossé Foundation promotes the training of healthcare personnel in the use of Madagascan essential oils in Madagascar
\n
March 6th 2017 – Gattefossé certified RSPO Mass Balance
\n
February 8th 2017 – New launch: Gatuline® Link n Lift – Redesign the eye contour
\n
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Our sensorial emollients are dedicated to all fields of application. They contribute to the formation of a protective film and maintain the barrier function of the skin.
\n","use_level":"1-30%","naturalite":"ECOCERT / COSMOS approvedAlone or in combination, the complementarity of chemical structures of our emollients gives formulators the possibility to create cosmetic products with a unique sensoriality.
\n\nLabrafac™ CC MB:
\nMOD MB:
\nDPPG CG:
\nIsostearyl Isostearate:
\nAll fields of application
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Gattefossé’s four application laboratories are located in France, China, India, and the United States. These strategic positions permit close, local relationships with our customers.
\n
\n
\n
\n
A nonionic oil-in-water emulsifier for topical formulations. It delivers high stability for a wide range of APIs in emulsions. Widely used in vaginal creams due to high mucosal tolerance.
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