Did you know that age spots are the first sign of aging in Asian skin, and the third major aging concern of European and American women, after wrinkles and sagging? Though we often think of wrinkles as the primary issue, 70% of all people over 55 have at least a few age spots.1 Age spots, or dark spots, are permanent hyperpigmented marks that appear on UV-exposed areas of the skin. Although it was previously believed that these spots form primarily in the epidermis, recent research suggests that the health of the dermis also plays a role in their formation. Gatuline® Spot-Light is the first ingredient to diminish these spots while brightening complexion—through targeted preventive and curative action at the epidermal and dermal levels.
Butylene Glycol (and)
Actinidia Chinensis (Kiwi)
Fruit Water (and) Alcohol (and)
Sophora Flavescens Root Extract
Gatuline® Spot-Light is obtained by extracting active molecules from Asian Sophora flavescens and handpicked Italian kiwi. Our strict sourcing standards ensure continuous supply and appropriate concentrations of key molecules, while preserving the natural growth and health of the plants.
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In vitro and in vivo tests prove Gatuline® Spot-Light
significantly reduces age spot visibility and density
diminishes spots by blurring their perimeters,
significantly reduces the size of age spots after 56 days,
has antioxidant and anti-inflammatory effects that shield against future age spot formation.
Claims
Reduces visibility and number of age spots
Diminishes appearance of dark spots
Acts on epidermal and dermal causes of age spots
Lightens skin tone
Applications
Targeted age-spot treatments
Skin perfectors, foundations, and concealers
Brightening products
Alphabet creams
Global anti-aging lines
FORMULATIONS
Direct access to technical information and documents
Poor solubility, poor permeability, and pre-systemic elimination are factors that can limit absorption of somedrugs. Lipid excipients have the capability to overcome these hurdles and enhance oral bioavailability throughdifferent mechanisms.
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How to develop lipid-based formulation?
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An optimized LBF enables solubilization of the entire therapeutic dose andmaintains the drug in solubilized state throughout the digestion process.
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To speed up LBF development, we have produced tools to guide you at each stageof development:
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1 – methods for saturation solubility screening
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2 – database of solubility of drugs in common pharmaceutical excipients
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3 – methods for miscibility and dispersability testing
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4 – miscibility table
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5 – in vitro lipolysis procedure
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6 – guideline for preclinical studies
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What are the different types of lipid-based formulations?
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Depending on their composition, LBF exhibit different in vivo behaviors. They typically consist of biocompatible excipients falling into four main categories: oils, low-HLB surfactants, high HLB surfactants and co-solvents. To facilitate their identification, Poutonet al. introduced the Lipid Formulation Classification System based on the composition, size of the droplets generated after the dispersion of the formulation in aqueous media, and the impact of natural lipid digestion process on the in vivo performance of the formulation classes.
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What functional excipients for oral bioavailability enhancement do Gattefossé deliver?
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Our range of functional excipients includes oils, low HLB surfactants, high HLB surfactants and solvents. They can be combined to formulate all types of lipid-based formulations
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What are self-emulsifying formulations?
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Self-emulsifying lipid formulations form emulsions upon contact with aqueous fluids without the need for mechanical or thermal energy.The size of the dispersion depends on the composition of excipients in the formulation.
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How to use lipid excipients and lipid-based formulations in early stage development?
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A vehicle or formula intended for preclinical studies must allow adequate administration of the test compound with little or no effect on the test species. The vehicle or formulation must be suitable for the intended route of administration, maintain the stability of the active ingredient, and preferably, maximize the systemic bioavailability of the drug. Lipid excipients provide a solution to these challenges and have proven utility in preclinical studies. Further information is available from Gattefossé guideline
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\n\n\n","box_links":[{"link":false,"title":"Download our brochure","external_link":"https://www.gattefosse.com/back/files/Brochure_Gattefosse_Lipid-based%20formulations%20a%20winning%20strategy%20to%20overcome%20oral%20bioavailability%20challenges.pdf","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/01/54370-e1612972328251.jpg"},{"link":false,"title":"Simple and effective design of SEDDS formulations","external_link":"https://www.youtube.com/watch?v=E2HnSAVyzHU&t=46s ","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/01/auto-self-emulsifying.jpg"}],"useful_links":[{"text_link":"Developing lipid-based formulations","link":"https://www.gattefosse.com/pharmaceuticals-special-content/lipid-based-formulations-development/","external_link":""},{"text_link":"Excipients for solubility and bioavailability enhancement ","link":"https://www.gattefosse.com/pharmaceuticals-content/excipients-for-solubility-and-bioavailability-enhancement/","external_link":""},{"text_link":"Guide for successful preclinical studies with Gattefossé excipients","link":"https://www.gattefosse.com/pharmaceuticals-content/guide-for-successful-preclinical-studies-with-gattefosse-excipients/","external_link":""},{"text_link":"Lipid-based formulations : a winning strategy for oral bioavailability enhancement","link":"https://www.gattefosse.com/pharmaceuticals-content/lipid-based-formulations-winning-strategy-oral-bioavailability-enhancement/","external_link":""}],"":false,"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22909"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=22909"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22909/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=22909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=22909"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=22909"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"capryol-pgmc":{"id":2189,"date":"2017-04-20T09:08:42","date_gmt":"2017-04-20T09:08:42","guid":{"rendered":"https://www.gattefosse.com:443/wordpress/?page_id=2189"},"modified":"2022-05-09T10:27:24","modified_gmt":"2022-05-09T08:27:24","slug":"capryol-pgmc","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-products/capryol-pgmc/","title":{"rendered":"Capryol® PGMC"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Capryol® PGMC -Propylene glycol monocaprylate type I - Surfactant","_yoast_wpseo_metadesc":"Capryol® PGMC is a nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS."},"categories":[7],"tags":[],"acf":{"component":"PageProductPharma","":false,"product_codes":[{"code":"3241"}],"product_image":{"id":13616,"alt":"","title":"liquid","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1.jpg","width":1716,"height":600,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"product_title":"Capryol® PGMC","introduction":"
A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
\n","names_kv":[{"keys":"USP NF Name","value":"
Propylene Glycol Mono and Dicaprylate NF \n[May also be labeled as Propylene Glycol Monocaprylate (type I) NF until December 1, 2026]
\n"},{"keys":"EP Name","value":"
/
\n"},{"keys":"UNII Code (FDA)","value":"
RT9P9S09QI
\n"},{"keys":"Preferred Substance Name (FDA)","value":"
PROPYLENE GLYCOL CAPRYLATE
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"
Propylene glycol monocaprylate
\n"},{"keys":"Chemical description","value":"
Consists of propylene glycol esters of caprylic acid (C8), composed of mono- and diesters.
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation. Safety of use is inferred by precedence of use in approved pharmaceutical products.
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Every woman faces a gynecological disorder at some point in her life, during puberty, maternity, menopause or post menopause. These age periods structure the women’s health market with treatments for menopause related disorders, postmenopausal osteoporosis, infertility, endometriosis, gynecological cancer and birth control.
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For a healthy vaginal flora
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Equilibrium of the vaginal flora is fragile and is easily altered by external factors such as:
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Hormonal changes with menopause, oestro-progestative birth control pills, diabetes
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Excessive hygiene
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Medicines such as antibiotics
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Stress
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Tobacco
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Probiotics are known to restore the vaginal flora, either by local treatment or oral administration, the latter being the most efficient. They can also be administered preventively during pregnancy for women with recurrent fungal infections or in combination with antibiotic treatments. Probiotics to restore vaginal flora are available as:
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Oral tablets with precedence of use of Precirol® ATO 5 (glyceryl distearate) and Compritol® 888 ATO (glyceryl dibehenate) as lubricants
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Vaginal suppositories with Suppocire® and Ovucire® (hard fats) as pessary base
At menopause many changes occur with the drop in hormones inducing vaginal dryness, among other symptoms. Hyaluronic acid is frequently used for mucosa hydration in creams using Tefose® 63 (mixture of PEG-6 stearate and ethylene glycol palmitostearate and PEG-32 stearate) and Labrafil® M 2130 CS (lauroyl polyoxyl-6 glycerides) or in pessaries using hard fats. In the Application Laboratory in Saint Priest a pessary formulation was developed with 0.25% of hyaluronic acid 99.75% Ovucire® WL 3264. Product characteristics are as follows:
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Homogeneous beige pessary\r\nMelting point 34.9°C +/- 0.1°C\r\nMecanical stress > 5.400 Kg\r\nLiquefaction time 8 min 18 s +/- 25 s
Antifungal agents such as clotrimazole, metronidazole or miconazole nitrate are listed on the WHO Essential Medicines List. They are frequently formulated in pessaries and/or creams to treat vaginal infections.
Hard fat suppository base with emulsifier to improve dispersion of hydrophilic APIs, recommended for formulation of glycerin suppositories.
\n","names_kv":[{"keys":"USP NF Name","value":"
Hard fat EP/NF/JPE with Glycerol Monostearate EP/NF and PEG-75 Stearate (type I) NF
\n"},{"keys":"EP Name","value":"
Hard fat EP/NF/JPE with Glycerol monostearate EP/NF and PEG-75 Stearate (type I) NF
\n"},{"keys":"UNII Code (FDA)","value":"
8334LX7S21 230OU9XXE4 OT38R0N74H
\n"},{"keys":"Preferred Substance Name (FDA)","value":"
FAT, HARD GLYCERYL MONOSTEARATE PEG-75 STEARATE
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"
Suppository bases, hard fat
\n"},{"keys":"Chemical description","value":"
Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant and containing glycerol monostearate (C18) and PEG-75 (MW 3500) stearate (C18)
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Did you know that age spots are the first sign of aging in Asian skin, and the third major aging concern of European and American women, after wrinkles and sagging? Though we often think of wrinkles as the primary issue, 70% of all people over 55 have at least a few age spots.1 Age spots, or dark spots, are permanent hyperpigmented marks that appear on UV-exposed areas of the skin. Although it was previously believed that these spots form primarily in the epidermis, recent research suggests that the health of the dermis also plays a role in their formation. Gatuline® Spot-Light is the first ingredient to diminish these spots while brightening complexion—through targeted preventive and curative action at the epidermal and dermal levels.
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