Monosteol™

A lipidic vehicle used as consistency agent in topical formulations. Enhances stability by preventing phase separation and oil droplet coalescence.

Names and synonyms

USP NF Name

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EP Name

Propylene glycol monopalmitostearate

UNII Code (FDA)

F76354LMGR

Preferred Substance Name (FDA)

PROPYLENE GLYCOL MONOPALMITOSTEARATE

Handbook of Pharmaceutical Excipients

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Chemical description

Consists of propylene glycol esters of palmitic (C16) and stearic (C18) acids, the monoester fraction being predominant

Key characteristics

Product form

Waxy solid

Melting range (°C)

33 – 40

HLB

4

Main functionalities

Consistency agent for oily phase in topical formulations.
Stability-improving agent.
Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies